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Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

Author

Listed:
  • Vikaas S. Sohal

    (W083 Clark Center, 318 Campus Drive West, Stanford University, Stanford, California 94305, USA)

  • Feng Zhang

    (W083 Clark Center, 318 Campus Drive West, Stanford University, Stanford, California 94305, USA)

  • Ofer Yizhar

    (W083 Clark Center, 318 Campus Drive West, Stanford University, Stanford, California 94305, USA)

  • Karl Deisseroth

    (W083 Clark Center, 318 Campus Drive West, Stanford University, Stanford, California 94305, USA)

Abstract

Sensory transmission Gamma oscillations, synchronous activity rhythms in the neuronal network measured between 20 and 80 Hz, are active during information processing and attention, and are dysregulated in schizophrenia. What induces this activity band has been the subject of speculation and theory. Two papers in this issue report the use of cell-type-targeted optogenetic technologies to test the currently favoured theory — that these oscillations are generated by synchronous activity of fast-spiking (FS) interneurons, also known as parvalbumin-expressing interneurons. The results suggest that the theory is correct. Cardin et al. show that a gamma state can be driven by specific activation of FS interneurons in vivo, and that sensory input relative to these oscillations can determine the extent of evoked cortical activity. Sohal et al. report empirical evidence for the involvement of specific activation of FS interneurons in the production of gamma oscillations, and their data too suggest that gamma-based modulation of excitatory cells may enhance the signal-to-noise ratio in circuits.

Suggested Citation

  • Vikaas S. Sohal & Feng Zhang & Ofer Yizhar & Karl Deisseroth, 2009. "Parvalbumin neurons and gamma rhythms enhance cortical circuit performance," Nature, Nature, vol. 459(7247), pages 698-702, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7247:d:10.1038_nature07991
    DOI: 10.1038/nature07991
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    1. Hidenori Tabata & Megumi Sasaki & Masakazu Agetsuma & Hitomi Sano & Yuki Hirota & Michio Miyajima & Kanehiro Hayashi & Takao Honda & Masashi Nishikawa & Yutaka Inaguma & Hidenori Ito & Hirohide Takeba, 2022. "Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Tal Sharf & Tjitse Molen & Stella M. K. Glasauer & Elmer Guzman & Alessio P. Buccino & Gabriel Luna & Zhuowei Cheng & Morgane Audouard & Kamalini G. Ranasinghe & Kiwamu Kudo & Srikantan S. Nagarajan &, 2022. "Functional neuronal circuitry and oscillatory dynamics in human brain organoids," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. W Gordon Frankle & Raymond Y Cho & N Scott Mason & Chi-Min Chen & Michael Himes & Christopher Walker & David A Lewis & Chester A Mathis & Rajesh Narendran, 2012. "[11C]flumazenil Binding Is Increased in a Dose-Dependent Manner with Tiagabine-Induced Elevations in GABA Levels," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-9, February.
    4. Tommaso Ianni & Sedona N. Ewbank & Marjorie R. Levinstein & Matine M. Azadian & Reece C. Budinich & Michael Michaelides & Raag D. Airan, 2024. "Sex dependence of opioid-mediated responses to subanesthetic ketamine in rats," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Sorinel A Oprisan & Xandre Clementsmith & Tamas Tompa & Antonieta Lavin, 2019. "Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-39, October.
    6. Shaojian Lin & Anke Zhang & Ling Yuan & Yufan Wang & Chuan Zhang & Junkun Jiang & Houshi Xu & Huiwen Yuan & Hui Yao & Qianying Zhang & Yong Zhang & Meiqing Lou & Ping Wang & Zhen-Ning Zhang & Bing Lua, 2022. "Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Xin Fu & Eric Teboul & Grant L. Weiss & Pantelis Antonoudiou & Chandrashekhar D. Borkar & Jonathan P. Fadok & Jamie Maguire & Jeffrey G. Tasker, 2022. "Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Emma Leishman & Brian F O’Donnell & James B Millward & Jenifer L Vohs & Olga Rass & Giri P Krishnan & Amanda R Bolbecker & Sandra L Morzorati, 2015. "Phencyclidine Disrupts the Auditory Steady State Response in Rats," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-20, August.
    9. Michael J Gandal & Addie May Nesbitt & Richard M McCurdy & Mark D Alter, 2012. "Measuring the Maturity of the Fast-Spiking Interneuron Transcriptional Program in Autism, Schizophrenia, and Bipolar Disorder," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-8, August.
    10. Stefano Berto & Alex H. Treacher & Emre Caglayan & Danni Luo & Jillian R. Haney & Michael J. Gandal & Daniel H. Geschwind & Albert A. Montillo & Genevieve Konopka, 2022. "Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    11. Yu-Jun Wang & Gui-Ying Zan & Cenglin Xu & Xue-Ping Li & Xuelian Shu & Song-Yu Yao & Xiao-Shan Xu & Xiaoyun Qiu & Yexiang Chen & Kai Jin & Qi-Xin Zhou & Jia-Yu Ye & Yi Wang & Lin Xu & Zhong Chen & Jing, 2023. "The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    12. Daigo Takeuchi & Dheeraj Roy & Shruti Muralidhar & Takashi Kawai & Andrea Bari & Chanel Lovett & Heather A. Sullivan & Ian R. Wickersham & Susumu Tonegawa, 2022. "Cingulate-motor circuits update rule representations for sequential choice decisions," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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