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Crystal structure of the human sterol transporter ABCG5/ABCG8

Author

Listed:
  • Jyh-Yeuan Lee

    (Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas)

  • Lisa N. Kinch

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center)

  • Dominika M. Borek

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Jin Wang

    (Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas)

  • Junmei Wang

    (Cecil & Ida Green Center for Molecular, Computational and Systems Biology, University of Texas Southwestern Medical Center)

  • Ina L. Urbatsch

    (Texas Tech University Health Sciences Center)

  • Xiao-Song Xie

    (Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas)

  • Nikolai V. Grishin

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center)

  • Jonathan C. Cohen

    (Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas)

  • Zbyszek Otwinowski

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Helen H. Hobbs

    (Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center)

  • Daniel M. Rosenbaum

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

Abstract

The X-ray structure of human ABCG5/ABCG8 heterodimer in a nucleotide-free state, being the first atomic model of an ABC sterol transporter.

Suggested Citation

  • Jyh-Yeuan Lee & Lisa N. Kinch & Dominika M. Borek & Jin Wang & Junmei Wang & Ina L. Urbatsch & Xiao-Song Xie & Nikolai V. Grishin & Jonathan C. Cohen & Zbyszek Otwinowski & Helen H. Hobbs & Daniel M. , 2016. "Crystal structure of the human sterol transporter ABCG5/ABCG8," Nature, Nature, vol. 533(7604), pages 561-564, May.
    • Handle: RePEc:nat:nature:v:533:y:2016:i:7604:d:10.1038_nature17666
    DOI: 10.1038/nature17666
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    Cited by:

    1. Jere P. Segrest & Chongren Tang & Hyun D. Song & Martin K. Jones & W. Sean Davidson & Stephen G. Aller & Jay W. Heinecke, 2022. "ABCA1 is an extracellular phospholipid translocase," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Young Jin Kim & Sanghoon Moon & Mi Yeong Hwang & Sohee Han & Hye-Mi Jang & Jinhwa Kong & Dong Mun Shin & Kyungheon Yoon & Sung Min Kim & Jong-Eun Lee & Anubha Mahajan & Hyun-Young Park & Mark I. McCar, 2022. "The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Jessica Fernandes Scortecci & Laurie L. Molday & Susan B. Curtis & Fabian A. Garces & Pankaj Panwar & Filip Petegem & Robert S. Molday, 2021. "Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    4. Alejandro Marín-Medina & Gonzalo Ruíz-Hidalgo & Jorge L. Blé-Castillo & Alma M. Zetina-Esquivel & Rodrigo Miranda Zamora & Isela E. Juárez-Rojop & Juan C. Díaz-Zagoya, 2019. "Combined Effect of Diosgenin Along with Ezetimibe or Atorvastatin on the Fate of Labelled Bile Acid and Cholesterol in Hypercholesterolemic Rats," IJERPH, MDPI, vol. 16(4), pages 1-10, February.

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