IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-32912-x.html
   My bibliography  Save this article

Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks

Author

Listed:
  • Ru-Siou Hsu

    (National Tsing Hua University)

  • Ssu-Ju Li

    (National Yang Ming Chiao Tung University)

  • Jen-Hung Fang

    (National Tsing Hua University)

  • I-Chi Lee

    (National Tsing Hua University)

  • Li-An Chu

    (National Tsing Hua University
    National Tsing Hua University)

  • Yu-Chun Lo

    (Taipei Medical University)

  • Yu-Jen Lu

    (College of Medicine Chang Gung University
    Chang Gung University, Kwei-San)

  • You-Yin Chen

    (National Yang Ming Chiao Tung University
    Taipei Medical University
    National Yang Ming Chiao Tung University)

  • Shang-Hsiu Hu

    (National Tsing Hua University)

Abstract

Traumatic brain injury causes inflammation and glial scarring that impede brain tissue repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here we present an adaptable conductive microporous hydrogel consisting of gold nanoyarn balls-coated injectable building blocks possessing interconnected pores to improve angiogenesis and recovery of brain function in traumatic brain injury. We show that following minimally invasive implantation, the adaptable hydrogel is able to fill defects with complex shapes and regulate the traumatic brain injury environment in a mouse model. We find that placement of this injectable hydrogel at peri-trauma regions enhances mature brain-derived neurotrophic factor by 180% and improves angiogenesis by 250% in vivo within 2 weeks after electromagnetized stimulation, and that these effects facilitate neuron survival and motor function recovery by 50%. We use blood oxygenation level-dependent functional neuroimaging to reveal the successful restoration of functional brain connectivity in the corticostriatal and corticolimbic circuits.

Suggested Citation

  • Ru-Siou Hsu & Ssu-Ju Li & Jen-Hung Fang & I-Chi Lee & Li-An Chu & Yu-Chun Lo & Yu-Jen Lu & You-Yin Chen & Shang-Hsiu Hu, 2022. "Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32912-x
    DOI: 10.1038/s41467-022-32912-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-32912-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-32912-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Bo Zhu & Shyh-Chyang Luo & Haichao Zhao & Hsing-An Lin & Jun Sekine & Aiko Nakao & Chi Chen & Yoshiro Yamashita & Hsiao-hua Yu, 2014. "Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer," Nature Communications, Nature, vol. 5(1), pages 1-9, December.
    2. Laura Fedele & Joseph Newcombe & Maya Topf & Alasdair Gibb & Robert J. Harvey & Trevor G. Smart, 2018. "Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    3. Sebastián L. Vega & Mi Y. Kwon & Kwang Hoon Song & Chao Wang & Robert L. Mauck & Lin Han & Jason A. Burdick, 2018. "Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    4. Carol Kilkenny & William J Browne & Innes C Cuthill & Michael Emerson & Douglas G Altman, 2010. "Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research," PLOS Biology, Public Library of Science, vol. 8(6), pages 1-5, June.
    5. Kang-Il Song & Hyunseon Seo & Duhwan Seong & Seunghoe Kim & Ki Jun Yu & Yu-Chan Kim & Jinseok Kim & Seok Joon Kwon & Hyung-Seop Han & Inchan Youn & Hyojin Lee & Donghee Son, 2020. "Adaptive self-healing electronic epineurium for chronic bidirectional neural interfaces," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    6. Zhihong Chen & Walid Jalabi & Weiwei Hu & Hyun-Joo Park & John T. Gale & Grahame J. Kidd & Rodica Bernatowicz & Zachary C. Gossman & Jacqueline T. Chen & Ranjan Dutta & Bruce D. Trapp, 2014. "Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dean A Fergusson & Marc T Avey & Carly C Barron & Mathew Bocock & Kristen E Biefer & Sylvain Boet & Stephane L Bourque & Isidora Conic & Kai Chen & Yuan Yi Dong & Grace M Fox & Ronald B George & Neil , 2019. "Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-15, May.
    2. Faith H. Brennan & Yang Li & Cankun Wang & Anjun Ma & Qi Guo & Yi Li & Nicole Pukos & Warren A. Campbell & Kristina G. Witcher & Zhen Guan & Kristina A. Kigerl & Jodie C. E. Hall & Jonathan P. Godbout, 2022. "Microglia coordinate cellular interactions during spinal cord repair in mice," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Zhongwei Xu & Bingze Xu & Susanna L. Lundström & Àlex Moreno-Giró & Danxia Zhao & Myriam Martin & Erik Lönnblom & Qixing Li & Alexander Krämer & Changrong Ge & Lei Cheng & Bibo Liang & Dongmei Tong & , 2023. "A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Nathalie Percie du Sert & Viki Hurst & Amrita Ahluwalia & Sabina Alam & Marc T Avey & Monya Baker & William J Browne & Alejandra Clark & Innes C Cuthill & Ulrich Dirnagl & Michael Emerson & Paul Garne, 2020. "The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research," PLOS Biology, Public Library of Science, vol. 18(7), pages 1-12, July.
    5. Vivian Leung & Frédérik Rousseau-Blass & Guy Beauchamp & Daniel S J Pang, 2018. "ARRIVE has not ARRIVEd: Support for the ARRIVE (Animal Research: Reporting of in vivo Experiments) guidelines does not improve the reporting quality of papers in animal welfare, analgesia or anesthesi," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-13, May.
    6. Claudia Kurreck & Esmeralda Castaños-Vélez & Dorette Freyer & Sonja Blumenau & Ingo Przesdzing & Rene Bernard & Ulrich Dirnagl, 2020. "Improving quality of preclinical academic research through auditing: A feasibility study," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-15, October.
    7. Katsumasa Irie & Yoshinori Oda & Takashi Sumikama & Atsunori Oshima & Yoshinori Fujiyoshi, 2023. "The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    8. Beverly S Muhlhausler & Frank H Bloomfield & Matthew W Gillman, 2013. "Whole Animal Experiments Should Be More Like Human Randomized Controlled Trials," PLOS Biology, Public Library of Science, vol. 11(2), pages 1-6, February.
    9. Constance Holman & Sophie K Piper & Ulrike Grittner & Andreas Antonios Diamantaras & Jonathan Kimmelman & Bob Siegerink & Ulrich Dirnagl, 2016. "Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke," PLOS Biology, Public Library of Science, vol. 14(1), pages 1-12, January.
    10. Zixin Li & Danqing He & Bowen Guo & Zekun Wang & Huajie Yu & Yu Wang & Shanshan Jin & Min Yu & Lisha Zhu & Liyuan Chen & Chengye Ding & Xiaolan Wu & Tianhao Wu & Shiqiang Gong & Jing Mao & Yanheng Zho, 2023. "Self-promoted electroactive biomimetic mineralized scaffolds for bacteria-infected bone regeneration," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    11. Zheng Zhang & Baoyong Sha & Lingzhu Zhao & Huan Zhang & Jinteng Feng & Cheng Zhang & Lin Sun & Meiqing Luo & Bin Gao & Hui Guo & Zheng Wang & Feng Xu & Tian Jian Lu & Guy M. Genin & Min Lin, 2022. "Programmable integrin and N-cadherin adhesive interactions modulate mechanosensing of mesenchymal stem cells by cofilin phosphorylation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    12. Bertha Estrella & Elena N. Naumova & Magda Cepeda & Trudy Voortman & Peter D. Katsikis & Hemmo A. Drexhage, 2019. "Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies," IJERPH, MDPI, vol. 16(13), pages 1-15, July.
    13. Emily M Wong & Fern Tablin & Edward S Schelegle, 2020. "Comparison of nonparametric and parametric methods for time-frequency heart rate variability analysis in a rodent model of cardiovascular disease," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-15, November.
    14. Jonathan Mauricio Muñoz-Cabrera & Adrián Gabriel Sandoval-Hernández & Andrea Niño & Tatiana Báez & Angie Bustos-Rangel & Gloria Patricia Cardona-Gómez & Alejandro Múnera & Gonzalo Arboleda, 2019. "Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-22, October.
    15. Konstantinos K Tsilidis & Orestis A Panagiotou & Emily S Sena & Eleni Aretouli & Evangelos Evangelou & David W Howells & Rustam Al-Shahi Salman & Malcolm R Macleod & John P A Ioannidis, 2013. "Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases," PLOS Biology, Public Library of Science, vol. 11(7), pages 1-10, July.
    16. Olivia Hogue & Tucker Harvey & Dena Crozier & Claire Sonneborn & Abagail Postle & Hunter Block-Beach & Eashwar Somasundaram & Francis J May & Monica Snyder Braun & Felicia L Pasadyn & Khandi King & Ca, 2022. "Statistical practice and transparent reporting in the neurosciences: Preclinical motor behavioral experiments," PLOS ONE, Public Library of Science, vol. 17(3), pages 1-17, March.
    17. Marta Liliana Musskopf & Amanda Finger Stadler & Ulf ME Wikesjö & Cristiano Susin, 2022. "The minipig intraoral dental implant model: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-17, February.
    18. Ming Yang & Lufang Wang & Wenliang Liu & Wenlong Li & Yewei Huang & Qiaofeng Jin & Li Zhang & Yuanwen Jiang & Zhiqiang Luo, 2024. "Highly-stable, injectable, conductive hydrogel for chronic neuromodulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    19. Stefan Boehme & Bastian Duenges & Klaus U Klein & Volker Hartwich & Beate Mayr & Jolanda Consiglio & James E Baumgardner & Klaus Markstaller & Reto Basciani & Andreas Vogt, 2013. "Multi Frequency Phase Fluorimetry (MFPF) for Oxygen Partial Pressure Measurement: Ex Vivo Validation by Polarographic Clark-Type Electrode," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-8, April.
    20. Hristo Todorov & Emily Searle-White & Susanne Gerber, 2020. "Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the example of a controlled preclinical neurotrauma trial," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-20, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32912-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.