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Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Author

Listed:
  • Malcolm R Macleod
  • Aaron Lawson McLean
  • Aikaterini Kyriakopoulou
  • Stylianos Serghiou
  • Arno de Wilde
  • Nicki Sherratt
  • Theo Hirst
  • Rachel Hemblade
  • Zsanett Bahor
  • Cristina Nunes-Fonseca
  • Aparna Potluru
  • Andrew Thomson
  • Julija Baginskitae
  • Kieren Egan
  • Hanna Vesterinen
  • Gillian L Currie
  • Leonid Churilov
  • David W Howells
  • Emily S Sena

Abstract

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.A systematic analysis of in vivo research reveals poor reporting of measures that reduce the risk of bias and an inverse relationship between impact factor and the reporting of randomization.

Suggested Citation

  • Malcolm R Macleod & Aaron Lawson McLean & Aikaterini Kyriakopoulou & Stylianos Serghiou & Arno de Wilde & Nicki Sherratt & Theo Hirst & Rachel Hemblade & Zsanett Bahor & Cristina Nunes-Fonseca & Aparn, 2015. "Risk of Bias in Reports of In Vivo Research: A Focus for Improvement," PLOS Biology, Public Library of Science, vol. 13(10), pages 1-12, October.
    • Handle: RePEc:plo:pbio00:1002273
    DOI: 10.1371/journal.pbio.1002273
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