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Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

Author

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  • Bo Zhu

    (Responsive Organic Materials Laboratory, RIKEN
    State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University)

  • Shyh-Chyang Luo

    (Responsive Organic Materials Laboratory, RIKEN
    National Cheng Kung University)

  • Haichao Zhao

    (Responsive Organic Materials Laboratory, RIKEN)

  • Hsing-An Lin

    (Responsive Organic Materials Laboratory, RIKEN
    Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology)

  • Jun Sekine

    (Responsive Organic Materials Laboratory, RIKEN)

  • Aiko Nakao

    (RNC Nuclear Spectroscopy Laboratory, RIKEN, Wako)

  • Chi Chen

    (Research Center for Applied Sciences, Academia Sinica, Nankang)

  • Yoshiro Yamashita

    (Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology)

  • Hsiao-hua Yu

    (Responsive Organic Materials Laboratory, RIKEN
    Institute of Chemistry, Academia Sinica)

Abstract

Although electrically stimulated neurite outgrowth on bioelectronic devices is a promising means of nerve regeneration, immunogenic scar formation can insulate electrodes from targeted cells and tissues, thereby reducing the lifetime of the device. Ideally, an electrode material capable of electrically interfacing with neurons selectively and efficiently would be integrated without being recognized by the immune system and minimize its response. Here we develop a cell membrane-mimicking conducting polymer possessing several attractive features. This polymer displays high resistance towards nonspecific enzyme/cell binding and recognizes targeted cells specifically to allow intimate electrical communication over long periods of time. Its low electrical impedance relays electrical signals efficiently. This material is capable to integrate biochemical and electrical stimulation to promote neural cellular behaviour. Neurite outgrowth is enhanced greatly on this new conducting polymer; in addition, electrically stimulated secretion of proteins from primary Schwann cells can also occur on it.

Suggested Citation

  • Bo Zhu & Shyh-Chyang Luo & Haichao Zhao & Hsing-An Lin & Jun Sekine & Aiko Nakao & Chi Chen & Yoshiro Yamashita & Hsiao-hua Yu, 2014. "Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer," Nature Communications, Nature, vol. 5(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5523
    DOI: 10.1038/ncomms5523
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    Cited by:

    1. Ru-Siou Hsu & Ssu-Ju Li & Jen-Hung Fang & I-Chi Lee & Li-An Chu & Yu-Chun Lo & Yu-Jen Lu & You-Yin Chen & Shang-Hsiu Hu, 2022. "Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Zixin Li & Danqing He & Bowen Guo & Zekun Wang & Huajie Yu & Yu Wang & Shanshan Jin & Min Yu & Lisha Zhu & Liyuan Chen & Chengye Ding & Xiaolan Wu & Tianhao Wu & Shiqiang Gong & Jing Mao & Yanheng Zho, 2023. "Self-promoted electroactive biomimetic mineralized scaffolds for bacteria-infected bone regeneration," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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