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Population-based tract-to-region connectome of the human brain and its hierarchical topology

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  • Fang-Cheng Yeh

    (University of Pittsburgh
    University of Pittsburgh)

Abstract

Connectome maps region-to-region connectivities but does not inform which white matter pathways form the connections. Here we constructed a population-based tract-to-region connectome to fill this information gap. The constructed connectome quantifies the population probability of a white matter tract innervating a cortical region. The results show that ~85% of the tract-to-region connectome entries are consistent across individuals, whereas the remaining (~15%) have substantial individual differences requiring individualized mapping. Further hierarchical clustering on cortical regions revealed dorsal, ventral, and limbic networks based on the tract-to-region connective patterns. The clustering results on white matter bundles revealed the categorization of fiber bundle systems in the association pathways. This tract-to-region connectome provides insights into the connective topology between cortical regions and white matter bundles. The derived hierarchical relation further offers a categorization of gray and white matter structures.

Suggested Citation

  • Fang-Cheng Yeh, 2022. "Population-based tract-to-region connectome of the human brain and its hierarchical topology," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32595-4
    DOI: 10.1038/s41467-022-32595-4
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    References listed on IDEAS

    as
    1. Michel Thiebaut de Schotten & Chris Foulon & Parashkev Nachev, 2020. "Brain disconnections link structural connectivity with function and behaviour," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    2. Klaus H. Maier-Hein & Peter F. Neher & Jean-Christophe Houde & Marc-Alexandre Côté & Eleftherios Garyfallidis & Jidan Zhong & Maxime Chamberland & Fang-Cheng Yeh & Ying-Chia Lin & Qing Ji & Wilburn E., 2017. "The challenge of mapping the human connectome based on diffusion tractography," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
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    1. Evan Collins & Omar Chishti & Sami Obaid & Hari McGrath & Alex King & Xilin Shen & Jagriti Arora & Xenophon Papademetris & R. Todd Constable & Dennis D. Spencer & Hitten P. Zaveri, 2024. "Mapping the structure-function relationship along macroscale gradients in the human brain," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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