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Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons

Author

Listed:
  • Tina Pekec

    (Friedrich Miescher Institute for Biomedical Research
    University of Basel, Faculty of Natural Sciences)

  • Jarosław Lewandowski

    (Polish Academy of Sciences)

  • Alicja A. Komur

    (Polish Academy of Sciences)

  • Daria Sobańska

    (Polish Academy of Sciences)

  • Yanwu Guo

    (University of Oslo, Department of Biosciences)

  • Karolina Świtońska-Kurkowska

    (Polish Academy of Sciences)

  • Jędrzej M. Małecki

    (University of Oslo, Department of Biosciences)

  • Abhishek Anil Dubey

    (International Institute of Molecular and Cell Biology in Warsaw)

  • Wojciech Pokrzywa

    (International Institute of Molecular and Cell Biology in Warsaw)

  • Marcin Frankowski

    (Adam Mickiewicz University in Poznań, Faculty of Chemistry)

  • Maciej Figiel

    (Polish Academy of Sciences)

  • Rafal Ciosk

    (Polish Academy of Sciences
    University of Oslo, Department of Biosciences)

Abstract

How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans, we uncovered a regulatory axis that enhances the natural resistance of nematodes to severe cold. This axis involves conserved transcription factors, DAF-16/FoxO and PQM-1, which jointly promote cold survival by upregulating FTN-1, a protein related to mammalian ferritin heavy chain (FTH1). Moreover, we show that inducing expression of FTH1 also promotes cold survival of mammalian neurons, a cell type particularly sensitive to deterioration in hypothermia. Our findings in both animals and cells suggest that FTN-1/FTH1 facilitates cold survival by detoxifying ROS-generating iron species. We finally show that mimicking the effects of FTN-1/FTH1 with drugs protects neurons from cold-induced degeneration, opening a potential avenue to improved treatments of hypothermia.

Suggested Citation

  • Tina Pekec & Jarosław Lewandowski & Alicja A. Komur & Daria Sobańska & Yanwu Guo & Karolina Świtońska-Kurkowska & Jędrzej M. Małecki & Abhishek Anil Dubey & Wojciech Pokrzywa & Marcin Frankowski & Mac, 2022. "Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32500-z
    DOI: 10.1038/s41467-022-32500-z
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    References listed on IDEAS

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    2. Akane Ohta & Tomoyo Ujisawa & Satoru Sonoda & Atsushi Kuhara, 2014. "Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    3. C. Daniel De Magalhaes Filho & Brian Henriquez & Nicole E. Seah & Ronald M. Evans & Louis R. Lapierre & Andrew Dillin, 2018. "Visible light reduces C. elegans longevity," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
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