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Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans

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  • Akane Ohta

    (Laboratory of Molecular and Cellular Regulation, Faculty of Science and Engineering, Institute for Integrative Neurobiology, Konan University)

  • Tomoyo Ujisawa

    (Laboratory of Molecular and Cellular Regulation, Faculty of Science and Engineering, Institute for Integrative Neurobiology, Konan University)

  • Satoru Sonoda

    (Laboratory of Molecular and Cellular Regulation, Faculty of Science and Engineering, Institute for Integrative Neurobiology, Konan University)

  • Atsushi Kuhara

    (Laboratory of Molecular and Cellular Regulation, Faculty of Science and Engineering, Institute for Integrative Neurobiology, Konan University)

Abstract

Temperature is a critical environmental stimulus that has a strong impact on an organism’s biochemistry. Animals can respond to changes in ambient temperature through behaviour or altered physiology. However, how animals habituate to temperature is poorly understood. The nematode C. elegans stores temperature experiences and can induce temperature habituation-linked cold tolerance. Here we show that light and pheromone-sensing neurons (ASJ) regulate cold habituation through insulin signalling. Calcium imaging reveals that ASJ neurons respond to temperature. Cold habituation is abnormal in a mutant with impaired cGMP signalling in ASJ neurons. Insulin released from ASJ neurons is received by the intestine and neurons regulating gene expression for cold habituation. Thus, temperature sensation in a light and pheromone-sensing neuron produces a robust effect on insulin signalling that controls experience-dependent temperature habituation.

Suggested Citation

  • Akane Ohta & Tomoyo Ujisawa & Satoru Sonoda & Atsushi Kuhara, 2014. "Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5412
    DOI: 10.1038/ncomms5412
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    Cited by:

    1. Chenxi Lin & Yuxin Shan & Zhongyi Wang & Hui Peng & Rong Li & Pingzhou Wang & Junyan He & Weiwei Shen & Zhengxing Wu & Min Guo, 2024. "Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Tina Pekec & Jarosław Lewandowski & Alicja A. Komur & Daria Sobańska & Yanwu Guo & Karolina Świtońska-Kurkowska & Jędrzej M. Małecki & Abhishek Anil Dubey & Wojciech Pokrzywa & Marcin Frankowski & Mac, 2022. "Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Kohei Ohnishi & Takaaki Sokabe & Toru Miura & Makoto Tominaga & Akane Ohta & Atsushi Kuhara, 2024. "G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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