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Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity

Author

Listed:
  • Michimasa Fujiogi

    (Harvard Medical School)

  • Yoshihiko Raita

    (Harvard Medical School)

  • Marcos Pérez-Losada

    (The George Washington University
    Universidade do Porto, Campus Agrário de Vairão)

  • Robert J. Freishtat

    (Children’s National Hospital
    Children’s National Hospital
    George Washington University School of Medicine and Health Sciences)

  • Juan C. Celedón

    (University of Pittsburgh)

  • Jonathan M. Mansbach

    (Boston Children’s Hospital, Harvard Medical School)

  • Pedro A. Piedra

    (Baylor College of Medicine)

  • Zhaozhong Zhu

    (Harvard Medical School)

  • Carlos A. Camargo

    (Harvard Medical School)

  • Kohei Hasegawa

    (Harvard Medical School)

Abstract

Bronchiolitis is a leading cause of infant hospitalizations but its immunopathology remains poorly understood. Here we present data from 244 infants hospitalized with bronchiolitis in a multicenter prospective study, assessing the host response (transcriptome), microbial composition, and microbial function (metatranscriptome) in the nasopharyngeal airway, and associate them with disease severity. We investigate individual associations with disease severity identify host response, microbial taxonomical, and microbial functional modules by network analyses. We also determine the integrated relationship of these modules with severity. Several modules are significantly associated with risks of positive pressure ventilation use, including the host-type I interferon, neutrophil/interleukin-1, T cell regulation, microbial-branched-chain amino acid metabolism, and nicotinamide adenine dinucleotide hydrogen modules. Taken together, we show complex interplays between host and microbiome, and their contribution to disease severity.

Suggested Citation

  • Michimasa Fujiogi & Yoshihiko Raita & Marcos Pérez-Losada & Robert J. Freishtat & Juan C. Celedón & Jonathan M. Mansbach & Pedro A. Piedra & Zhaozhong Zhu & Carlos A. Camargo & Kohei Hasegawa, 2022. "Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32323-y
    DOI: 10.1038/s41467-022-32323-y
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    References listed on IDEAS

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    Cited by:

    1. Zhaozhong Zhu & Yijun Li & Robert J. Freishtat & Juan C. Celedón & Janice A. Espinola & Brennan Harmon & Andrea Hahn & Carlos A. Camargo & Liming Liang & Kohei Hasegawa, 2023. "Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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