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T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

Author

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  • Eoin F. McKinney

    (University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus)

  • James C. Lee

    (University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus)

  • David R. W. Jayne

    (University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital)

  • Paul A. Lyons

    (University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus)

  • Kenneth G. C. Smith

    (University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus)

Abstract

CD8 T-cell exhaustion, although a negative prognostic indicator during persistent infections, is shown to be associated with a good outcome in autoimmune and inflammatory diseases.

Suggested Citation

  • Eoin F. McKinney & James C. Lee & David R. W. Jayne & Paul A. Lyons & Kenneth G. C. Smith, 2015. "T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection," Nature, Nature, vol. 523(7562), pages 612-616, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7562:d:10.1038_nature14468
    DOI: 10.1038/nature14468
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    Cited by:

    1. Ting Zhong & Xinyu Li & Kang Lei & Rong Tang & Qiaolin Deng & Paul E Love & Zhiguang Zhou & Bin Zhao & Xia Li, 2024. "TGF-β-mediated crosstalk between TIGIT+ Tregs and CD226+CD8+ T cells in the progression and remission of type 1 diabetes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Michimasa Fujiogi & Yoshihiko Raita & Marcos Pérez-Losada & Robert J. Freishtat & Juan C. Celedón & Jonathan M. Mansbach & Pedro A. Piedra & Zhaozhong Zhu & Carlos A. Camargo & Kohei Hasegawa, 2022. "Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Edward Jenkins & Markus Körbel & Caitlin O’Brien-Ball & James McColl & Kevin Y. Chen & Mateusz Kotowski & Jane Humphrey & Anna H. Lippert & Heather Brouwer & Ana Mafalda Santos & Steven F. Lee & Simon, 2023. "Antigen discrimination by T cells relies on size-constrained microvillar contact," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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