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The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Author

Listed:
  • Qingbo S. Wang

    (Osaka University Graduate School of Medicine
    Osaka University)

  • Ryuya Edahiro

    (Osaka University Graduate School of Medicine
    Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Ho Namkoong

    (Keio University School of Medicine)

  • Takanori Hasegawa

    (Tokyo Medical and Dental University)

  • Yuya Shirai

    (Osaka University Graduate School of Medicine
    Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Kyuto Sonehara

    (Osaka University Graduate School of Medicine
    Osaka University)

  • Hiromu Tanaka

    (Keio University School of Medicine)

  • Ho Lee

    (Keio University School of Medicine)

  • Ryunosuke Saiki

    (Kyoto University)

  • Takayoshi Hyugaji

    (the University of Tokyo)

  • Eigo Shimizu

    (the University of Tokyo)

  • Kotoe Katayama

    (the University of Tokyo)

  • Masahiro Kanai

    (Harvard Medical School)

  • Tatsuhiko Naito

    (Osaka University Graduate School of Medicine)

  • Noah Sasa

    (Osaka University Graduate School of Medicine
    Osaka University Graduate School of Medicine)

  • Kenichi Yamamoto

    (Osaka University Graduate School of Medicine
    Osaka University
    Osaka University Graduate School of Medicine)

  • Yasuhiro Kato

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
    Osaka University)

  • Takayoshi Morita

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
    Osaka University)

  • Kazuhisa Takahashi

    (Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Norihiro Harada

    (Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Toshio Naito

    (Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Makoto Hiki

    (Juntendo University Faculty of Medicine and Graduate School of Medicine
    Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Yasushi Matsushita

    (Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Haruhi Takagi

    (Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Masako Ichikawa

    (Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Ai Nakamura

    (Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Sonoko Harada

    (Juntendo University Faculty of Medicine and Graduate School of Medicine
    Juntendo University Graduate School of Medicine)

  • Yuuki Sandhu

    (Juntendo University Faculty of Medicine and Graduate School of Medicine)

  • Hiroki Kabata

    (Keio University School of Medicine)

  • Katsunori Masaki

    (Keio University School of Medicine)

  • Hirofumi Kamata

    (Keio University School of Medicine)

  • Shinnosuke Ikemura

    (Keio University School of Medicine)

  • Shotaro Chubachi

    (Keio University School of Medicine)

  • Satoshi Okamori

    (Keio University School of Medicine)

  • Hideki Terai

    (Keio University School of Medicine)

  • Atsuho Morita

    (Keio University School of Medicine)

  • Takanori Asakura

    (Keio University School of Medicine)

  • Junichi Sasaki

    (Keio University School of Medicine)

  • Hiroshi Morisaki

    (Keio University School of Medicine)

  • Yoshifumi Uwamino

    (Keio University School of Medicine)

  • Kosaku Nanki

    (Keio University School of Medicine)

  • Sho Uchida

    (Keio University School of Medicine)

  • Shunsuke Uno

    (Keio University School of Medicine)

  • Tomoyasu Nishimura

    (Keio University School of Medicine
    Keio University Health Center)

  • Takashri Ishiguro

    (Saitama Cardiovascular and Respiratory Center)

  • Taisuke Isono

    (Saitama Cardiovascular and Respiratory Center)

  • Shun Shibata

    (Saitama Cardiovascular and Respiratory Center)

  • Yuma Matsui

    (Saitama Cardiovascular and Respiratory Center)

  • Chiaki Hosoda

    (Saitama Cardiovascular and Respiratory Center)

  • Kenji Takano

    (Saitama Cardiovascular and Respiratory Center)

  • Takashi Nishida

    (Saitama Cardiovascular and Respiratory Center)

  • Yoichi Kobayashi

    (Saitama Cardiovascular and Respiratory Center)

  • Yotaro Takaku

    (Saitama Cardiovascular and Respiratory Center)

  • Noboru Takayanagi

    (Saitama Cardiovascular and Respiratory Center)

  • Soichiro Ueda

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Ai Tada

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Masayoshi Miyawaki

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Masaomi Yamamoto

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Eriko Yoshida

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Reina Hayashi

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Tomoki Nagasaka

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Sawako Arai

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Yutaro Kaneko

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Kana Sasaki

    (JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine)

  • Etsuko Tagaya

    (Tokyo Women’s Medical University)

  • Masatoshi Kawana

    (Tokyo Women’s Medical University)

  • Ken Arimura

    (Tokyo Women’s Medical University)

  • Kunihiko Takahashi

    (Tokyo Medical and Dental University)

  • Tatsuhiko Anzai

    (Tokyo Medical and Dental University)

  • Satoshi Ito

    (Tokyo Medical and Dental University)

  • Akifumi Endo

    (Tokyo Medical and Dental University Hospital of Medicine)

  • Yuji Uchimura

    (Tokyo Medical and Dental University Hospital of Medicine)

  • Yasunari Miyazaki

    (Tokyo Medical and Dental University)

  • Takayuki Honda

    (Tokyo Medical and Dental University)

  • Tomoya Tateishi

    (Tokyo Medical and Dental University)

  • Shuji Tohda

    (Tokyo Medical and Dental University Hospital of Medicine)

  • Naoya Ichimura

    (Tokyo Medical and Dental University Hospital of Medicine)

  • Kazunari Sonobe

    (Tokyo Medical and Dental University Hospital of Medicine)

  • Chihiro Tani Sassa

    (Tokyo Medical and Dental University Hospital of Medicine)

  • Jun Nakajima

    (Tokyo Medical and Dental University Hospital of Medicine)

  • Yasushi Nakano

    (Department of Internal Medicine)

  • Yukiko Nakajima

    (Department of Internal Medicine)

  • Ryusuke Anan

    (Department of Internal Medicine)

  • Ryosuke Arai

    (Department of Internal Medicine)

  • Yuko Kurihara

    (Department of Internal Medicine)

  • Yuko Harada

    (Department of Internal Medicine)

  • Kazumi Nishio

    (Department of Internal Medicine)

  • Tetsuya Ueda

    (Osaka Saiseikai Nakatsu Hospital)

  • Masanori Azuma

    (Osaka Saiseikai Nakatsu Hospital)

  • Ryuichi Saito

    (Osaka Saiseikai Nakatsu Hospital)

  • Toshikatsu Sado

    (Osaka Saiseikai Nakatsu Hospital)

  • Yoshimune Miyazaki

    (Osaka Saiseikai Nakatsu Hospital)

  • Ryuichi Sato

    (Osaka Saiseikai Nakatsu Hospital)

  • Yuki Haruta

    (Osaka Saiseikai Nakatsu Hospital)

  • Tadao Nagasaki

    (Osaka Saiseikai Nakatsu Hospital)

  • Yoshinori Yasui

    (Osaka Saiseikai Nakatsu Hospital)

  • Yoshinori Hasegawa

    (Osaka Saiseikai Nakatsu Hospital)

  • Yoshikazu Mutoh

    (Tosei General Hospital)

  • Tomoki Kimura

    (Tosei General Hospital)

  • Tomonori Sato

    (Tosei General Hospital)

  • Reoto Takei

    (Tosei General Hospital)

  • Satoshi Hagimoto

    (Tosei General Hospital)

  • Yoichiro Noguchi

    (Tosei General Hospital)

  • Yasuhiko Yamano

    (Tosei General Hospital)

  • Hajime Sasano

    (Tosei General Hospital)

  • Sho Ota

    (Tosei General Hospital)

  • Yasushi Nakamori

    (Kansai Medical University General Medical Center)

  • Kazuhisa Yoshiya

    (Kansai Medical University General Medical Center)

  • Fukuki Saito

    (Kansai Medical University General Medical Center)

  • Tomoyuki Yoshihara

    (Kansai Medical University General Medical Center)

  • Daiki Wada

    (Kansai Medical University General Medical Center)

  • Hiromu Iwamura

    (Kansai Medical University General Medical Center)

  • Syuji Kanayama

    (Kansai Medical University General Medical Center)

  • Shuhei Maruyama

    (Kansai Medical University General Medical Center)

  • Takashi Yoshiyama

    (Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital)

  • Ken Ohta

    (Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital)

  • Hiroyuki Kokuto

    (Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital)

  • Hideo Ogata

    (Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital)

  • Yoshiaki Tanaka

    (Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital)

  • Kenichi Arakawa

    (Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital)

  • Masafumi Shimoda

    (Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital)

  • Takeshi Osawa

    (Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital)

  • Hiroki Tateno

    (Saitama City Hospital)

  • Isano Hase

    (Saitama City Hospital)

  • Shuichi Yoshida

    (Saitama City Hospital)

  • Shoji Suzuki

    (Saitama City Hospital)

  • Miki Kawada

    (Saitama City Hospital)

  • Hirohisa Horinouchi

    (Saitama City Hospital)

  • Fumitake Saito

    (Eiju General Hospital)

  • Keiko Mitamura

    (Eiju General Hospital)

  • Masao Hagihara

    (Eiju General Hospital)

  • Junichi Ochi

    (Eiju General Hospital)

  • Tomoyuki Uchida

    (Eiju General Hospital)

  • Rie Baba

    (Saiseikai Utsunomiya Hospital)

  • Daisuke Arai

    (Saiseikai Utsunomiya Hospital)

  • Takayuki Ogura

    (Saiseikai Utsunomiya Hospital)

  • Hidenori Takahashi

    (Saiseikai Utsunomiya Hospital)

  • Shigehiro Hagiwara

    (Saiseikai Utsunomiya Hospital)

  • Genta Nagao

    (Saiseikai Utsunomiya Hospital)

  • Shunichiro Konishi

    (Saiseikai Utsunomiya Hospital)

  • Ichiro Nakachi

    (Saiseikai Utsunomiya Hospital)

  • Koji Murakami

    (Tohoku University Graduate School of Medicine)

  • Mitsuhiro Yamada

    (Tohoku University Graduate School of Medicine)

  • Hisatoshi Sugiura

    (Tohoku University Graduate School of Medicine)

  • Hirohito Sano

    (Tohoku University Graduate School of Medicine)

  • Shuichiro Matsumoto

    (Tohoku University Graduate School of Medicine)

  • Nozomu Kimura

    (Tohoku University Graduate School of Medicine)

  • Yoshinao Ono

    (Tohoku University Graduate School of Medicine)

  • Hiroaki Baba

    (Tohoku University Graduate School of Medicine)

  • Yusuke Suzuki

    (Kitasato University Kitasato Institute Hospital)

  • Sohei Nakayama

    (Kitasato University Kitasato Institute Hospital)

  • Keita Masuzawa

    (Kitasato University Kitasato Institute Hospital)

  • Shinichi Namba

    (Osaka University Graduate School of Medicine)

  • Takayuki Shiroyama

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Yoshimi Noda

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Takayuki Niitsu

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Yuichi Adachi

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Takatoshi Enomoto

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Saori Amiya

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Reina Hara

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Yuta Yamaguchi

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
    Osaka University)

  • Teruaki Murakami

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
    Osaka University)

  • Tomoki Kuge

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Kinnosuke Matsumoto

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Yuji Yamamoto

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Makoto Yamamoto

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Midori Yoneda

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Kazunori Tomono

    (Osaka University Hospital)

  • Kazuto Kato

    (Osaka University Graduate School of Medicine)

  • Haruhiko Hirata

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Yoshito Takeda

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine)

  • Hidefumi Koh

    (Tachikawa Hospital)

  • Tadashi Manabe

    (Tachikawa Hospital)

  • Yohei Funatsu

    (Tachikawa Hospital)

  • Fumimaro Ito

    (Tachikawa Hospital)

  • Takahiro Fukui

    (Tachikawa Hospital)

  • Keisuke Shinozuka

    (Tachikawa Hospital)

  • Sumiko Kohashi

    (Tachikawa Hospital)

  • Masatoshi Miyazaki

    (Tachikawa Hospital)

  • Tomohisa Shoko

    (Tokyo Women’s Medical University Medical Center East)

  • Mitsuaki Kojima

    (Tokyo Women’s Medical University Medical Center East)

  • Tomohiro Adachi

    (Tokyo Women’s Medical University Medical Center East)

  • Motonao Ishikawa

    (Tokyo Women’s Medical University Medical Center East)

  • Kenichiro Takahashi

    (Tokyo Women’s Medical University Medical Center East)

  • Takashi Inoue

    (Sano Kosei General Hospital)

  • Toshiyuki Hirano

    (Sano Kosei General Hospital)

  • Keigo Kobayashi

    (Sano Kosei General Hospital)

  • Hatsuyo Takaoka

    (Sano Kosei General Hospital)

  • Kazuyoshi Watanabe

    (Japan Community Health care Organization Kanazawa Hospital)

  • Naoki Miyazawa

    (Saiseikai Yokohamashi Nanbu Hospital)

  • Yasuhiro Kimura

    (Saiseikai Yokohamashi Nanbu Hospital)

  • Reiko Sado

    (Saiseikai Yokohamashi Nanbu Hospital)

  • Hideyasu Sugimoto

    (Saiseikai Yokohamashi Nanbu Hospital)

  • Akane Kamiya

    (Saiseikai Yokohamashi Nanbu Hospital)

  • Naota Kuwahara

    (Showa University Koto Toyosu Hospital)

  • Akiko Fujiwara

    (Showa University Koto Toyosu Hospital)

  • Tomohiro Matsunaga

    (Showa University Koto Toyosu Hospital)

  • Yoko Sato

    (Showa University Koto Toyosu Hospital)

  • Takenori Okada

    (Showa University Koto Toyosu Hospital)

  • Yoshihiro Hirai

    (Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital)

  • Hidetoshi Kawashima

    (Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital)

  • Atsuya Narita

    (Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital)

  • Kazuki Niwa

    (Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital)

  • Yoshiyuki Sekikawa

    (Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital)

  • Koichi Nishi

    (Ishikawa Prefectural Central Hospital)

  • Masaru Nishitsuji

    (Ishikawa Prefectural Central Hospital)

  • Mayuko Tani

    (Ishikawa Prefectural Central Hospital)

  • Junya Suzuki

    (Ishikawa Prefectural Central Hospital)

  • Hiroki Nakatsumi

    (Ishikawa Prefectural Central Hospital)

  • Takashi Ogura

    (Kanagawa Cardiovascular and Respiratory Center)

  • Hideya Kitamura

    (Kanagawa Cardiovascular and Respiratory Center)

  • Eri Hagiwara

    (Kanagawa Cardiovascular and Respiratory Center)

  • Kota Murohashi

    (Kanagawa Cardiovascular and Respiratory Center)

  • Hiroko Okabayashi

    (Kanagawa Cardiovascular and Respiratory Center)

  • Takao Mochimaru

    (National Hospital Organization Tokyo Medical Center
    National Hospital Organization Tokyo Medical Center)

  • Shigenari Nukaga

    (National Hospital Organization Tokyo Medical Center)

  • Ryosuke Satomi

    (National Hospital Organization Tokyo Medical Center)

  • Yoshitaka Oyamada

    (National Hospital Organization Tokyo Medical Center
    National Hospital Organization Tokyo Medical Center)

  • Nobuaki Mori

    (National Hospital Organization Tokyo Medical Center)

  • Tomoya Baba

    (Toyohashi Municipal Hospital)

  • Yasutaka Fukui

    (Toyohashi Municipal Hospital)

  • Mitsuru Odate

    (Toyohashi Municipal Hospital)

  • Shuko Mashimo

    (Toyohashi Municipal Hospital)

  • Yasushi Makino

    (Toyohashi Municipal Hospital)

  • Kazuma Yagi

    (Keiyu Hospital)

  • Mizuha Hashiguchi

    (Keiyu Hospital)

  • Junko Kagyo

    (Keiyu Hospital)

  • Tetsuya Shiomi

    (Keiyu Hospital)

  • Satoshi Fuke

    (KKR Sapporo Medical Center, Department of respiratory medicine)

  • Hiroshi Saito

    (KKR Sapporo Medical Center, Department of respiratory medicine)

  • Tomoya Tsuchida

    (St. Marianna University School of Medicine)

  • Shigeki Fujitani

    (St.Marianna University School of Medicine)

  • Mumon Takita

    (St.Marianna University School of Medicine)

  • Daiki Morikawa

    (St.Marianna University School of Medicine)

  • Toru Yoshida

    (St.Marianna University School of Medicine)

  • Takehiro Izumo

    (Japanese Red Cross Medical Center)

  • Minoru Inomata

    (Japanese Red Cross Medical Center)

  • Naoyuki Kuse

    (Japanese Red Cross Medical Center)

  • Nobuyasu Awano

    (Japanese Red Cross Medical Center)

  • Mari Tone

    (Japanese Red Cross Medical Center)

  • Akihiro Ito

    (Matsumoto City Hospital)

  • Yoshihiko Nakamura

    (Fukuoka University)

  • Kota Hoshino

    (Fukuoka University)

  • Junichi Maruyama

    (Fukuoka University)

  • Hiroyasu Ishikura

    (Fukuoka University)

  • Tohru Takata

    (Fukuoka University Hospital)

  • Toshio Odani

    (National Hospital Organization Hokkaido Medical Center)

  • Masaru Amishima

    (National Hospital Organization Hokkaido Medical Center)

  • Takeshi Hattori

    (National Hospital Organization Hokkaido Medical Center)

  • Yasuo Shichinohe

    (National Hospital Organization Hokkaido Medical Center)

  • Takashi Kagaya

    (National Hospital Organization Kanazawa Medical Center)

  • Toshiyuki Kita

    (National Hospital Organization Kanazawa Medical Center)

  • Kazuhide Ohta

    (National Hospital Organization Kanazawa Medical Center)

  • Satoru Sakagami

    (National Hospital Organization Kanazawa Medical Center)

  • Kiyoshi Koshida

    (National Hospital Organization Kanazawa Medical Center)

  • Kentaro Hayashi

    (Division of Respiratory Medicine)

  • Tetsuo Shimizu

    (Division of Respiratory Medicine)

  • Yutaka Kozu

    (Division of Respiratory Medicine)

  • Hisato Hiranuma

    (Division of Respiratory Medicine)

  • Yasuhiro Gon

    (Division of Respiratory Medicine)

  • Namiki Izumi

    (Musashino Red Cross Hospital)

  • Kaoru Nagata

    (Musashino Red Cross Hospital)

  • Ken Ueda

    (Musashino Red Cross Hospital)

  • Reiko Taki

    (Musashino Red Cross Hospital)

  • Satoko Hanada

    (Musashino Red Cross Hospital)

  • Kodai Kawamura

    (Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital)

  • Kazuya Ichikado

    (Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital)

  • Kenta Nishiyama

    (Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital)

  • Hiroyuki Muranaka

    (Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital)

  • Kazunori Nakamura

    (Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital)

  • Naozumi Hashimoto

    (Nagoya University Graduate School of Medicine)

  • Keiko Wakahara

    (Nagoya University Graduate School of Medicine)

  • Sakamoto Koji

    (Nagoya University Graduate School of Medicine)

  • Norihito Omote

    (Nagoya University Graduate School of Medicine)

  • Akira Ando

    (Nagoya University Graduate School of Medicine)

  • Nobuhiro Kodama

    (Fukuoka Tokushukai Hospital, Department of Internal Medicine)

  • Yasunari Kaneyama

    (Fukuoka Tokushukai Hospital, Department of Internal Medicine)

  • Shunsuke Maeda

    (Fukuoka Tokushukai Hospital, Department of Internal Medicine)

  • Takashige Kuraki

    (Fukuoka Tokushukai Hospital, Respiratory Medicine)

  • Takemasa Matsumoto

    (Fukuoka Tokushukai Hospital, Respiratory Medicine)

  • Koutaro Yokote

    (Chiba University Graduate School of Medicine)

  • Taka-Aki Nakada

    (Chiba University Graduate School of Medicine)

  • Ryuzo Abe

    (Chiba University Graduate School of Medicine)

  • Taku Oshima

    (Chiba University Graduate School of Medicine)

  • Tadanaga Shimada

    (Chiba University Graduate School of Medicine)

  • Masahiro Harada

    (National Hospital Organization Kumamoto Medical Center)

  • Takeshi Takahashi

    (National Hospital Organization Kumamoto Medical Center)

  • Hiroshi Ono

    (National Hospital Organization Kumamoto Medical Center)

  • Toshihiro Sakurai

    (National Hospital Organization Kumamoto Medical Center)

  • Takayuki Shibusawa

    (National Hospital Organization Kumamoto Medical Center)

  • Yoshifumi Kimizuka

    (National Defense Medical College)

  • Akihiko Kawana

    (National Defense Medical College)

  • Tomoya Sano

    (National Defense Medical College)

  • Chie Watanabe

    (National Defense Medical College)

  • Ryohei Suematsu

    (National Defense Medical College)

  • Hisako Sageshima

    (Sapporo City General Hospital)

  • Ayumi Yoshifuji

    (Tokyo Saiseikai Central Hospital)

  • Kazuto Ito

    (Tokyo Saiseikai Central Hospital)

  • Saeko Takahashi

    (Tokyo Saiseikai Central Hospital)

  • Kota Ishioka

    (Tokyo Saiseikai Central Hospital)

  • Morio Nakamura

    (Tokyo Saiseikai Central Hospital)

  • Makoto Masuda

    (Fujisawa City Hospital)

  • Aya Wakabayashi

    (Fujisawa City Hospital)

  • Hiroki Watanabe

    (Fujisawa City Hospital)

  • Suguru Ueda

    (Fujisawa City Hospital)

  • Masanori Nishikawa

    (Fujisawa City Hospital)

  • Yusuke Chihara

    (Uji-Tokushukai Medical Center)

  • Mayumi Takeuchi

    (Uji-Tokushukai Medical Center)

  • Keisuke Onoi

    (Uji-Tokushukai Medical Center)

  • Jun Shinozuka

    (Uji-Tokushukai Medical Center)

  • Atsushi Sueyoshi

    (Uji-Tokushukai Medical Center)

  • Yoji Nagasaki

    (National Hospital Organization Kyushu Medical Center)

  • Masaki Okamoto

    (National Hospital Organization Kyushu Medical Center
    Kurume University School of Medicine)

  • Sayoko Ishihara

    (National Hospital Organization Kyushu Medical Center)

  • Masatoshi Shimo

    (National Hospital Organization Kyushu Medical Center)

  • Yoshihisa Tokunaga

    (National Hospital Organization Kyushu Medical Center
    Kurume University School of Medicine)

  • Yu Kusaka

    (Ome Municipal General Hospital)

  • Takehiko Ohba

    (Ome Municipal General Hospital)

  • Susumu Isogai

    (Ome Municipal General Hospital)

  • Aki Ogawa

    (Ome Municipal General Hospital)

  • Takuya Inoue

    (Ome Municipal General Hospital)

  • Satoru Fukuyama

    (Kyushu University)

  • Yoshihiro Eriguchi

    (Kyushu University Graduate School of Medical Sciences)

  • Akiko Yonekawa

    (Kyushu University Graduate School of Medical Sciences)

  • Keiko Kan-o

    (Kyushu University)

  • Koichiro Matsumoto

    (Kyushu University)

  • Kensuke Kanaoka

    (Daini Osaka Police Hospital)

  • Shoichi Ihara

    (Daini Osaka Police Hospital)

  • Kiyoshi Komuta

    (Daini Osaka Police Hospital)

  • Yoshiaki Inoue

    (University of Tsukuba)

  • Shigeru Chiba

    (University of Tsukuba)

  • Kunihiro Yamagata

    (University of Tsukuba)

  • Yuji Hiramatsu

    (University of Tsukuba)

  • Hirayasu Kai

    (University of Tsukuba)

  • Koichiro Asano

    (Tokai University School of Medicine)

  • Tsuyoshi Oguma

    (Tokai University School of Medicine)

  • Yoko Ito

    (Tokai University School of Medicine)

  • Satoru Hashimoto

    (Kyoto Prefectural University of Medicine)

  • Masaki Yamasaki

    (Kyoto Prefectural University of Medicine)

  • Yu Kasamatsu

    (Kyoto Prefectural University of Medicine)

  • Yuko Komase

    (St Marianna University School of Medicine, Yokohama-City Seibu Hospital)

  • Naoya Hida

    (St Marianna University School of Medicine, Yokohama-City Seibu Hospital)

  • Takahiro Tsuburai

    (St Marianna University School of Medicine, Yokohama-City Seibu Hospital)

  • Baku Oyama

    (St Marianna University School of Medicine, Yokohama-City Seibu Hospital)

  • Minoru Takada

    (KINSHUKAI Hanwa The Second Hospital)

  • Hidenori Kanda

    (KINSHUKAI Hanwa The Second Hospital)

  • Yuichiro Kitagawa

    (Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine)

  • Tetsuya Fukuta

    (Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine)

  • Takahito Miyake

    (Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine)

  • Shozo Yoshida

    (Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine)

  • Shinji Ogura

    (Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine)

  • Shinji Abe

    (Tokyo Medical University Hospital)

  • Yuta Kono

    (Tokyo Medical University Hospital)

  • Yuki Togashi

    (Tokyo Medical University Hospital)

  • Hiroyuki Takoi

    (Tokyo Medical University Hospital)

  • Ryota Kikuchi

    (Tokyo Medical University Hospital)

  • Shinichi Ogawa

    (JA Toride medical hospital)

  • Tomouki Ogata

    (JA Toride medical hospital)

  • Shoichiro Ishihara

    (JA Toride medical hospital)

  • Arihiko Kanehiro

    (Okayama Rosai Hospital
    Himeji St. Mary’s Hospital)

  • Shinji Ozaki

    (Okayama Rosai Hospital)

  • Yasuko Fuchimoto

    (Okayama Rosai Hospital)

  • Sae Wada

    (Okayama Rosai Hospital)

  • Nobukazu Fujimoto

    (Okayama Rosai Hospital)

  • Kei Nishiyama

    (Niigata University)

  • Mariko Terashima

    (National Hospital Organization Kyoto Medical Center)

  • Satoru Beppu

    (National Hospital Organization Kyoto Medical Center)

  • Kosuke Yoshida

    (National Hospital Organization Kyoto Medical Center)

  • Osamu Narumoto

    (National Hospital Organization Tokyo Hospital Hospital)

  • Hideaki Nagai

    (National Hospital Organization Tokyo Hospital Hospital)

  • Nobuharu Ooshima

    (National Hospital Organization Tokyo Hospital Hospital)

  • Mitsuru Motegi

    (Fujioka General Hospital)

  • Akira Umeda

    (International University of Health and Welfare Shioya Hospital)

  • Kazuya Miyagawa

    (International University of Health and Welfare Shioya Hospital)

  • Hisato Shimada

    (International University of Health and Welfare Shioya Hospital)

  • Mayu Endo

    (International University of Health and Welfare Shioya Hospital)

  • Yoshiyuki Ohira

    (International University of Health and Welfare Shioya Hospital)

  • Masafumi Watanabe

    (Yamagata University Faculty of Medicine)

  • Sumito Inoue

    (Yamagata University Faculty of Medicine)

  • Akira Igarashi

    (Yamagata University Faculty of Medicine)

  • Masamichi Sato

    (Yamagata University Faculty of Medicine)

  • Hironori Sagara

    (Showa University)

  • Akihiko Tanaka

    (Showa University)

  • Shin Ohta

    (Showa University)

  • Tomoyuki Kimura

    (Showa University)

  • Yoko Shibata

    (Fukushima Medical University)

  • Yoshinori Tanino

    (Fukushima Medical University)

  • Takefumi Nikaido

    (Fukushima Medical University)

  • Hiroyuki Minemura

    (Fukushima Medical University)

  • Yuki Sato

    (Fukushima Medical University)

  • Yuichiro Yamada

    (Kansai Electric Power Hospital)

  • Takuya Hashino

    (Kansai Electric Power Hospital)

  • Masato Shinoki

    (Kansai Electric Power Hospital)

  • Hajime Iwagoe

    (Kumamoto City Hospital)

  • Hiroshi Takahashi

    (Kumamoto City Hospital)

  • Kazuhiko Fujii

    (Kumamoto City Hospital)

  • Hiroto Kishi

    (Kumamoto City Hospital)

  • Masayuki Kanai

    (Tokyo Metropolitan Police Hospital)

  • Tomonori Imamura

    (Tokyo Metropolitan Police Hospital)

  • Tatsuya Yamashita

    (Tokyo Metropolitan Police Hospital)

  • Masakiyo Yatomi

    (Gunma University Graduate School of Medicine)

  • Toshitaka Maeno

    (Gunma University Graduate School of Medicine)

  • Shinichi Hayashi

    (National hospital organization Saitama Hospital)

  • Mai Takahashi

    (National hospital organization Saitama Hospital)

  • Mizuki Kuramochi

    (National hospital organization Saitama Hospital)

  • Isamu Kamimaki

    (National hospital organization Saitama Hospital)

  • Yoshiteru Tominaga

    (National hospital organization Saitama Hospital)

  • Tomoo Ishii

    (Tokyo Medical University Ibaraki Medical Center)

  • Mitsuyoshi Utsugi

    (Kiryu Kosei General Hospital)

  • Akihiro Ono

    (Kiryu Kosei General Hospital)

  • Toru Tanaka

    (Nippon Medical School)

  • Takeru Kashiwada

    (Nippon Medical School)

  • Kazue Fujita

    (Nippon Medical School)

  • Yoshinobu Saito

    (Nippon Medical School)

  • Masahiro Seike

    (Nippon Medical School)

  • Hiroko Watanabe

    (Tsukuba Kinen General Hospital)

  • Hiroto Matsuse

    (Toho University Ohashi Medical Center)

  • Norio Kodaka

    (Toho University Ohashi Medical Center)

  • Chihiro Nakano

    (Toho University Ohashi Medical Center)

  • Takeshi Oshio

    (Toho University Ohashi Medical Center)

  • Takatomo Hirouchi

    (Toho University Ohashi Medical Center)

  • Shohei Makino

    (Kobe University Graduate School of Medicine)

  • Moritoki Egi

    (Kobe University Graduate School of Medicine)

  • Yosuke Omae

    (National Center for Global Health and Medicine)

  • Yasuhito Nannya

    (Kyoto University)

  • Takafumi Ueno

    (Graduate School of Tokyo Institute of Technology)

  • Tomomi Takano

    (Kitasato University)

  • Kazuhiko Katayama

    (Kitasato University)

  • Masumi Ai

    (Tokyo Medical and Dental University Hospital of Medicine)

  • Atsushi Kumanogoh

    (Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine
    Osaka University
    Osaka University
    Osaka University)

  • Toshiro Sato

    (Keio University School of Medicine)

  • Naoki Hasegawa

    (Keio University School of Medicine)

  • Katsushi Tokunaga

    (National Center for Global Health and Medicine)

  • Makoto Ishii

    (Keio University School of Medicine)

  • Ryuji Koike

    (Tokyo Medical and Dental University)

  • Yuko Kitagawa

    (Keio University School of Medicine)

  • Akinori Kimura

    (Tokyo Medical and Dental University)

  • Seiya Imoto

    (the University of Tokyo)

  • Satoru Miyano

    (Tokyo Medical and Dental University)

  • Seishi Ogawa

    (Kyoto University
    Kyoto University
    Karolinska Institute)

  • Takanori Kanai

    (Keio University Health Center
    AMED-CREST, Japan Agency for Medical Research and Development)

  • Koichi Fukunaga

    (Keio University School of Medicine)

  • Yukinori Okada

    (Osaka University Graduate School of Medicine
    Osaka University
    Osaka University
    Osaka University)

Abstract

Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.

Suggested Citation

  • Qingbo S. Wang & Ryuya Edahiro & Ho Namkoong & Takanori Hasegawa & Yuya Shirai & Kyuto Sonehara & Hiromu Tanaka & Ho Lee & Ryunosuke Saiki & Takayoshi Hyugaji & Eigo Shimizu & Kotoe Katayama & Masahir, 2022. "The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32276-2
    DOI: 10.1038/s41467-022-32276-2
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    as
    1. Claudia Giambartolomei & Damjan Vukcevic & Eric E Schadt & Lude Franke & Aroon D Hingorani & Chris Wallace & Vincent Plagnol, 2014. "Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics," PLOS Genetics, Public Library of Science, vol. 10(5), pages 1-15, May.
    2. Clare Bycroft & Colin Freeman & Desislava Petkova & Gavin Band & Lloyd T. Elliott & Kevin Sharp & Allan Motyer & Damjan Vukcevic & Olivier Delaneau & Jared O’Connell & Adrian Cortes & Samantha Welsh &, 2018. "The UK Biobank resource with deep phenotyping and genomic data," Nature, Nature, vol. 562(7726), pages 203-209, October.
    3. Gao Wang & Abhishek Sarkar & Peter Carbonetto & Matthew Stephens, 2020. "A simple new approach to variable selection in regression, with application to genetic fine mapping," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 82(5), pages 1273-1300, December.
    4. Qingbo S. Wang & David R. Kelley & Jacob Ulirsch & Masahiro Kanai & Shuvom Sadhuka & Ran Cui & Carlos Albors & Nathan Cheng & Yukinori Okada & Francois Aguet & Kristin G. Ardlie & Daniel G. MacArthur , 2021. "Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    5. Konrad J. Karczewski & Laurent C. Francioli & Grace Tiao & Beryl B. Cummings & Jessica Alföldi & Qingbo Wang & Ryan L. Collins & Kristen M. Laricchia & Andrea Ganna & Daniel P. Birnbaum & Laura D. Gau, 2020. "The mutational constraint spectrum quantified from variation in 141,456 humans," Nature, Nature, vol. 581(7809), pages 434-443, May.
    6. Eleonora Porcu & Marie C. Sadler & Kaido Lepik & Chiara Auwerx & Andrew R. Wood & Antoine Weihs & Maroun S. Bou Sleiman & Diogo M. Ribeiro & Stefania Bandinelli & Toshiko Tanaka & Matthias Nauck & Uwe, 2021. "Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    7. Tuuli Lappalainen & Michael Sammeth & Marc R. Friedländer & Peter A. C. ‘t Hoen & Jean Monlong & Manuel A. Rivas & Mar Gonzàlez-Porta & Natalja Kurbatova & Thasso Griebel & Pedro G. Ferreira & Matthia, 2013. "Transcriptome and genome sequencing uncovers functional variation in humans," Nature, Nature, vol. 501(7468), pages 506-511, September.
    Full references (including those not matched with items on IDEAS)

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