IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31781-8.html
   My bibliography  Save this article

Thalamo-hippocampal pathway regulates incidental memory capacity in mice

Author

Listed:
  • G. Torromino

    (Telethon Institute of Genetics and Medicine, Telethon Foundation
    Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

  • V. Loffredo

    (Telethon Institute of Genetics and Medicine, Telethon Foundation
    Institute of Biochemistry and Cell Biology (IBBC), National Research Council
    Sapienza University of Rome)

  • D. Cavezza

    (Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

  • G. Sonsini

    (Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

  • F. Esposito

    (Telethon Institute of Genetics and Medicine, Telethon Foundation)

  • A. H. Crevenna

    (Neurobiology and Epigenetics Unit, European Molecular Biology Laboratory (EMBL))

  • M. Gioffrè

    (Institute of Applied Sciences and Intelligent Systems (ISASI), National Research Council)

  • M. De Risi

    (Telethon Institute of Genetics and Medicine, Telethon Foundation
    Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

  • A. Treves

    (SISSA - Cognitive Neuroscience)

  • M. Griguoli

    (European Brain Research Institute (EBRI)
    Institute of Molecular Biology and Pathology (IBPM), National Research Council)

  • E. De Leonibus

    (Telethon Institute of Genetics and Medicine, Telethon Foundation
    Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

Abstract

Incidental memory can be challenged by increasing either the retention delay or the memory load. The dorsal hippocampus (dHP) appears to help with both consolidation from short-term (STM) to long-term memory (LTM), and higher memory loads, but the mechanism is not fully understood. Here we find that female mice, despite having the same STM capacity of 6 objects and higher resistance to distraction in our different object recognition task (DOT), when tested over 1 h or 24 h delays appear to transfer to LTM only 4 objects, whereas male mice have an STM capacity of 6 objects in this task. In male mice the dHP shows greater activation (as measured by c-Fos expression), whereas female mice show greater activation of the ventral midline thalamus (VMT). Optogenetic inhibition of the VMT-dHP pathway during off-line memory consolidation enables 6-object LTM retention in females, while chemogenetic VMT-activation impairs it in males. Thus, removing or enhancing sub-cortical inhibitory control over the hippocampus leads to differences in incidental memory.

Suggested Citation

  • G. Torromino & V. Loffredo & D. Cavezza & G. Sonsini & F. Esposito & A. H. Crevenna & M. Gioffrè & M. De Risi & A. Treves & M. Griguoli & E. De Leonibus, 2022. "Thalamo-hippocampal pathway regulates incidental memory capacity in mice," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31781-8
    DOI: 10.1038/s41467-022-31781-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31781-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31781-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Vijendra Sharma & Rapita Sood & Abdessattar Khlaifia & Mohammad Javad Eslamizade & Tzu-Yu Hung & Danning Lou & Azam Asgarihafshejani & Maya Lalzar & Stephen J. Kiniry & Matthew P. Stokes & Noah Cohen , 2020. "eIF2α controls memory consolidation via excitatory and somatostatin neurons," Nature, Nature, vol. 586(7829), pages 412-416, October.
    2. Hiroshi T. Ito & Sheng-Jia Zhang & Menno P. Witter & Edvard I. Moser & May-Britt Moser, 2015. "A prefrontal–thalamo–hippocampal circuit for goal-directed spatial navigation," Nature, Nature, vol. 522(7554), pages 50-55, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hannah Muysers & Hung-Ling Chen & Johannes Hahn & Shani Folschweiller & Torfi Sigurdsson & Jonas-Frederic Sauer & Marlene Bartos, 2024. "A persistent prefrontal reference frame across time and task rules," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Li Zheng & Zhiyao Gao & Andrew S. McAvan & Eve A. Isham & Arne D. Ekstrom, 2021. "Partially overlapping spatial environments trigger reinstatement in hippocampus and schema representations in prefrontal cortex," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    3. Maanasa Jayachandran & Tatiana D. Viena & Andy Garcia & Abdiel Vasallo Veliz & Sofia Leyva & Valentina Roldan & Robert P. Vertes & Timothy A. Allen, 2023. "Nucleus reuniens transiently synchronizes memory networks at beta frequencies," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. María P. Contreras & Marta Mendez & Xia Shan & Julia Fechner & Anuck Sawangjit & Jan Born & Marion Inostroza, 2024. "Context memory formed in medial prefrontal cortex during infancy enhances learning in adulthood," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Zihao Chen & Yechao Han & Zheng Ma & Xinnian Wang & Surui Xu & Yong Tang & Alexei L. Vyssotski & Bailu Si & Yang Zhan, 2024. "A prefrontal-thalamic circuit encodes social information for social recognition," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Jordan Crivelli-Decker & Alex Clarke & Seongmin A. Park & Derek J. Huffman & Erie D. Boorman & Charan Ranganath, 2023. "Goal-oriented representations in the human hippocampus during planning and navigation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31781-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.