Senescent cells limit p53 activity via multiple mechanisms to remain viable
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DOI: 10.1038/s41467-022-31239-x
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- Tae-Won Kang & Tetyana Yevsa & Norman Woller & Lisa Hoenicke & Torsten Wuestefeld & Daniel Dauch & Anja Hohmeyer & Marcus Gereke & Ramona Rudalska & Anna Potapova & Marcus Iken & Mihael Vucur & Siegfr, 2011. "Senescence surveillance of pre-malignant hepatocytes limits liver cancer development," Nature, Nature, vol. 479(7374), pages 547-551, November.
- Reut Yosef & Noam Pilpel & Ronit Tokarsky-Amiel & Anat Biran & Yossi Ovadya & Snir Cohen & Ezra Vadai & Liat Dassa & Elisheva Shahar & Reba Condiotti & Ittai Ben-Porath & Valery Krizhanovsky, 2016. "Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
- Jean-Philippe Coppé & Christopher K Patil & Francis Rodier & Yu Sun & Denise P Muñoz & Joshua Goldstein & Peter S Nelson & Pierre-Yves Desprez & Judith Campisi, 2008. "Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor," PLOS Biology, Public Library of Science, vol. 6(12), pages 1-1, December.
- Rene C. Adam & Hanseul Yang & Shira Rockowitz & Samantha B. Larsen & Maria Nikolova & Daniel S. Oristian & Lisa Polak & Meelis Kadaja & Amma Asare & Deyou Zheng & Elaine Fuchs, 2015. "Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice," Nature, Nature, vol. 521(7552), pages 366-370, May.
- Stephen C. Mack & Kristian W. Pajtler & Lukas Chavez & Konstantin Okonechnikov & Kelsey C. Bertrand & Xiuxing Wang & Serap Erkek & Alexander Federation & Anne Song & Christine Lee & Xin Wang & Laura M, 2018. "Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling," Nature, Nature, vol. 553(7686), pages 101-105, January.
- Jan M. van Deursen, 2014. "The role of senescent cells in ageing," Nature, Nature, vol. 509(7501), pages 439-446, May.
- Tyler J. Bussian & Asef Aziz & Charlton F. Meyer & Barbara L. Swenson & Jan M. van Deursen & Darren J. Baker, 2018. "Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline," Nature, Nature, vol. 562(7728), pages 578-582, October.
- Darren J. Baker & Bennett G. Childs & Matej Durik & Melinde E. Wijers & Cynthia J. Sieben & Jian Zhong & Rachel A. Saltness & Karthik B. Jeganathan & Grace Casaclang Verzosa & Abdulmohammad Pezeshki &, 2016. "Naturally occurring p16Ink4a-positive cells shorten healthy lifespan," Nature, Nature, vol. 530(7589), pages 184-189, February.
- Yuki Saito & Takako S. Chikenji & Takashi Matsumura & Masako Nakano & Mineko Fujimiya, 2020. "Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
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