Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
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DOI: 10.1038/nature16932
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- Jina Yun & Simon Hansen & Otto Morris & David T. Madden & Clare Peters Libeu & Arjun J. Kumar & Cameron Wehrfritz & Aaron H. Nile & Yingnan Zhang & Lijuan Zhou & Yuxin Liang & Zora Modrusan & Michelle, 2023. "Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
- Gorshkov, Vyacheslav & Privman, Vladimir & Libert, Sergiy, 2016. "Lattice percolation approach to 3D modeling of tissue aging," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 462(C), pages 207-216.
- Ines Sturmlechner & Chance C. Sine & Karthik B. Jeganathan & Cheng Zhang & Raul O. Fierro Velasco & Darren J. Baker & Hu Li & Jan M. Deursen, 2022. "Senescent cells limit p53 activity via multiple mechanisms to remain viable," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
- Toshiyuki Ko & Seitaro Nomura & Shintaro Yamada & Kanna Fujita & Takanori Fujita & Masahiro Satoh & Chio Oka & Manami Katoh & Masamichi Ito & Mikako Katagiri & Tatsuro Sassa & Bo Zhang & Satoshi Hatsu, 2022. "Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Cox, Lynne S., 2022. "Therapeutic approaches to treat and prevent age-related diseases through understanding the underlying biological drivers of ageing," The Journal of the Economics of Ageing, Elsevier, vol. 23(C).
- Leighton H. Daigh & Debarya Saha & David L. Rosenthal & Katherine R. Ferrick & Tobias Meyer, 2024. "Uncoupling of mTORC1 from E2F activity maintains DNA damage and senescence," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Ross J. Hill & Nazareno Bona & Job Smink & Hannah K. Webb & Alastair Crisp & Juan I. Garaycoechea & Gerry P. Crossan, 2024. "p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Yinsheng Wu & Lixu Tang & Han Huang & Qi Yu & Bicheng Hu & Gang Wang & Feng Ge & Tailang Yin & Shanshan Li & Xilan Yu, 2023. "Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
- Imanol Duran & Joaquim Pombo & Bin Sun & Suchira Gallage & Hiromi Kudo & Domhnall McHugh & Laura Bousset & Jose Efren Barragan Avila & Roberta Forlano & Pinelopi Manousou & Mathias Heikenwalder & Domi, 2024. "Detection of senescence using machine learning algorithms based on nuclear features," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
- Damien Maggiorani & Oanh Le & Véronique Lisi & Séverine Landais & Gaël Moquin-Beaudry & Vincent Philippe Lavallée & Hélène Decaluwe & Christian Beauséjour, 2024. "Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Yudong Fu & Fan Jiang & Xiao Zhang & Yingyi Pan & Rui Xu & Xiu Liang & Xiaofen Wu & Xingqiang Li & Kaixuan Lin & Ruona Shi & Xiaofei Zhang & Dominique Ferrandon & Jing Liu & Duanqing Pei & Jie Wang & , 2024. "Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
- Moh’d Mohanad Al-Dabet & Khurrum Shahzad & Ahmed Elwakiel & Alba Sulaj & Stefan Kopf & Fabian Bock & Ihsan Gadi & Silke Zimmermann & Rajiv Rana & Shruthi Krishnan & Dheerendra Gupta & Jayakumar Manoha, 2022. "Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Madison L. Doolittle & Dominik Saul & Japneet Kaur & Jennifer L. Rowsey & Stephanie J. Vos & Kevin D. Pavelko & Joshua N. Farr & David G. Monroe & Sundeep Khosla, 2023. "Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
- Xu Zhang & Vesselina M. Pearsall & Chase M. Carver & Elizabeth J. Atkinson & Benjamin D. S. Clarkson & Ethan M. Grund & Michelle Baez-Faria & Kevin D. Pavelko & Jennifer M. Kachergus & Thomas A. White, 2022. "Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Carlos Anerillas & Allison B. Herman & Rachel Munk & Amanda Garrido & Kwan-Wood Gabriel Lam & Matthew J. Payea & Martina Rossi & Dimitrios Tsitsipatis & Jennifer L. Martindale & Yulan Piao & Krystyna , 2022. "A BDNF-TrkB autocrine loop enhances senescent cell viability," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Jie Sun & Ming Wang & Yaqi Zhong & Xuan Ma & Shimin Sun & Chenzhong Xu & Linyuan Peng & Guo Li & Liting Zhang & Zuojun Liu & Ding Ai & Baohua Liu, 2022. "A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
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