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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Author

Listed:
  • Stephen C. Mack

    (Baylor College of Medicine
    Texas Children’s Cancer and Hematology Centers
    Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Kristian W. Pajtler

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK)
    Hematology and Immunology, Heidelberg University Hospital)

  • Lukas Chavez

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK)
    University of California – San Diego School of Medicine)

  • Konstantin Okonechnikov

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK))

  • Kelsey C. Bertrand

    (Baylor College of Medicine
    Texas Children’s Cancer and Hematology Centers
    Cleveland Clinic)

  • Xiuxing Wang

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    University of California – San Diego School of Medicine)

  • Serap Erkek

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK)
    European Molecular Biology Laboratory, Genome Biology Unit)

  • Alexander Federation

    (University of Washington)

  • Anne Song

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Christine Lee

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Xin Wang

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Laura McDonald

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • James J. Morrow

    (Case Western Reserve University)

  • Alina Saiakhova

    (Case Western Reserve University)

  • Patrick Sin-Chan

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Qiulian Wu

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    University of California – San Diego School of Medicine)

  • Kulandaimanuvel Antony Michaelraj

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Tyler E. Miller

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    Case Western Reserve University)

  • Christopher G. Hubert

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Marina Ryzhova

    (NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16)

  • Livia Garzia

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Laura Donovan

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Stephen Dombrowski

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic Neurological Institute, Cleveland Clinic)

  • Daniel C. Factor

    (Case Western Reserve University)

  • Betty Luu

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Claudia L. L. Valentim

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Ryan C. Gimple

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    University of California – San Diego School of Medicine
    Case Western Reserve University)

  • Andrew Morton

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    Case Western Reserve University)

  • Leo Kim

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    University of California – San Diego School of Medicine)

  • Briana C. Prager

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    University of California – San Diego School of Medicine)

  • John J. Y. Lee

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Xiaochong Wu

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Jennifer Zuccaro

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Yuan Thompson

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Borja L. Holgado

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Jüri Reimand

    (Computational Biology Program, Ontario Institute for Cancer Research
    University of Toronto)

  • Susan Q. Ke

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Adam Tropper

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Sisi Lai

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Senthuran Vijayarajah

    (Cleveland Clinic
    University of Utah School of Medicine)

  • Sylvia Doan

    (University of Utah School of Medicine)

  • Vaidehi Mahadev

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

  • Ana Fernandez Miñan

    (Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas and Universidad Pablo de Olavide)

  • Susanne N. Gröbner

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK))

  • Matthias Lienhard

    (Max-Planck-Institute for Molecular Genetics)

  • Marc Zapatka

    (German Cancer Research Center (DKFZ))

  • Zhiqin Huang

    (German Cancer Research Center (DKFZ))

  • Kenneth D. Aldape

    (University Health Network)

  • Angel M. Carcaboso

    (Preclinical Therapeutics and Drug Delivery Research Program, Fundacio Sant Joan de Deu)

  • Peter J. Houghton

    (Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases)

  • Stephen T. Keir

    (Duke University Medical Center)

  • Till Milde

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    Hematology and Immunology, Heidelberg University Hospital
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ))

  • Hendrik Witt

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK)
    Hematology and Immunology, Heidelberg University Hospital)

  • Yan Li

    (Case Western Reserve University)

  • Chao-Jun Li

    (MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, National Resource Centre for Mutant Mice)

  • Xiu-Wu Bian

    (Institute of Pathology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University, and The Key Laboratory of Tumor Immunopathology, The Ministry of Education of China)

  • David T. W. Jones

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK))

  • Ian Scott

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Sheila K. Singh

    (Faculty of Health Sciences, McMaster University)

  • Annie Huang

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
    Novartis Institutes for Biomedical Research)

  • Peter B. Dirks

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Eric Bouffet

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
    Novartis Institutes for Biomedical Research)

  • James E. Bradner

    (Novartis Institutes for Biomedical Research)

  • Vijay Ramaswamy

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
    Hospital for Sick Children)

  • Nada Jabado

    (McGill University and the McGill University Health Centre Research Institute)

  • James T. Rutka

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Paul A. Northcott

    (Developmental Neurobiology, St Jude Children’s Research Hospital)

  • Mathieu Lupien

    (University of Toronto)

  • Peter Lichter

    (German Cancer Research Center (DKFZ))

  • Andrey Korshunov

    (University of Heidelberg
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ))

  • Peter C. Scacheri

    (Case Western Reserve University)

  • Stefan M. Pfister

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK)
    Hematology and Immunology, Heidelberg University Hospital)

  • Marcel Kool

    (Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK))

  • Michael D. Taylor

    (Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children)

  • Jeremy N. Rich

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
    University of California – San Diego School of Medicine
    Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic Neurological Institute, Cleveland Clinic)

Abstract

Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.

Suggested Citation

  • Stephen C. Mack & Kristian W. Pajtler & Lukas Chavez & Konstantin Okonechnikov & Kelsey C. Bertrand & Xiuxing Wang & Serap Erkek & Alexander Federation & Anne Song & Christine Lee & Xin Wang & Laura M, 2018. "Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling," Nature, Nature, vol. 553(7686), pages 101-105, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7686:d:10.1038_nature25169
    DOI: 10.1038/nature25169
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    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
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    Cited by:

    1. Konstantin Okonechnikov & Aylin Camgöz & Owen Chapman & Sameena Wani & Donglim Esther Park & Jens-Martin Hübner & Abhijit Chakraborty & Meghana Pagadala & Rosalind Bump & Sahaana Chandran & Katerina K, 2023. "3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Ines Sturmlechner & Chance C. Sine & Karthik B. Jeganathan & Cheng Zhang & Raul O. Fierro Velasco & Darren J. Baker & Hu Li & Jan M. Deursen, 2022. "Senescent cells limit p53 activity via multiple mechanisms to remain viable," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Rachael G. Aubin & Emma C. Troisi & Javier Montelongo & Adam N. Alghalith & Maclean P. Nasrallah & Mariarita Santi & Pablo G. Camara, 2022. "Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Sibo Zhao & Jia Li & Huiyuan Zhang & Lin Qi & Yuchen Du & Mari Kogiso & Frank K. Braun & Sophie Xiao & Yulun Huang & Jianfang Li & Wan-Yee Teo & Holly Lindsay & Patricia Baxter & Jack M. F. Su & Adeku, 2022. "Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Royce W. Zhou & Jia Xu & Tiphaine C. Martin & Alexis L. Zachem & John He & Sait Ozturk & Deniz Demircioglu & Ankita Bansal & Andrew P. Trotta & Bruno Giotti & Berkley Gryder & Yao Shen & Xuewei Wu & S, 2022. "A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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