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The role of senescent cells in ageing

Author

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  • Jan M. van Deursen

    (Mayo Clinic College of Medicine)

Abstract

Cellular senescence has recently been shown to have roles in complex biological processes other than protection against cancer, and to represent a series of progressive and diverse cellular states after initial growth arrest; better understanding of mechanisms underlying its progression and of acute and chronic senescent cells may lead to new therapeutic strategies for age-related pathologies.

Suggested Citation

  • Jan M. van Deursen, 2014. "The role of senescent cells in ageing," Nature, Nature, vol. 509(7501), pages 439-446, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7501:d:10.1038_nature13193
    DOI: 10.1038/nature13193
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    Citations

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    Cited by:

    1. Jina Yun & Simon Hansen & Otto Morris & David T. Madden & Clare Peters Libeu & Arjun J. Kumar & Cameron Wehrfritz & Aaron H. Nile & Yingnan Zhang & Lijuan Zhou & Yuxin Liang & Zora Modrusan & Michelle, 2023. "Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Ines Sturmlechner & Chance C. Sine & Karthik B. Jeganathan & Cheng Zhang & Raul O. Fierro Velasco & Darren J. Baker & Hu Li & Jan M. Deursen, 2022. "Senescent cells limit p53 activity via multiple mechanisms to remain viable," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. He Cao & Panpan Yang & Jia Liu & Yan Shao & Honghao Li & Pinglin Lai & Hong Wang & Anling Liu & Bin Guo & Yujin Tang & Xiaochun Bai & Kai Li, 2023. "MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. José Luis García-Giménez & Salvador Mena-Molla & Francisco José Tarazona-Santabalbina & Jose Viña & Mari Carmen Gomez-Cabrera & Federico V. Pallardó, 2021. "Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers," IJERPH, MDPI, vol. 18(4), pages 1-17, February.
    5. Moore, Patrick V. & Bennett, Kathleen & Normand, Charles, 2017. "Counting the time lived, the time left or illness? Age, proximity to death, morbidity and prescribing expenditures," Social Science & Medicine, Elsevier, vol. 184(C), pages 1-14.
    6. Kaushik Bhattacharya & Samarpan Maiti & Szabolcs Zahoran & Lorenz Weidenauer & Dina Hany & Diana Wider & Lilia Bernasconi & Manfredo Quadroni & Martine Collart & Didier Picard, 2022. "Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    7. Konstantin Avchaciov & Marina P. Antoch & Ekaterina L. Andrianova & Andrei E. Tarkhov & Leonid I. Menshikov & Olga Burmistrova & Andrei V. Gudkov & Peter O. Fedichev, 2022. "Unsupervised learning of aging principles from longitudinal data," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Xu Zhang & Vesselina M. Pearsall & Chase M. Carver & Elizabeth J. Atkinson & Benjamin D. S. Clarkson & Ethan M. Grund & Michelle Baez-Faria & Kevin D. Pavelko & Jennifer M. Kachergus & Thomas A. White, 2022. "Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    9. Gaocai Li & Liang Ma & Shujie He & Rongjin Luo & Bingjin Wang & Weifeng Zhang & Yu Song & Zhiwei Liao & Wencan Ke & Qian Xiang & Xiaobo Feng & Xinghuo Wu & Yukun Zhang & Kun Wang & Cao Yang, 2022. "WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    10. Sara Rojas-Vázquez & Beatriz Lozano-Torres & Alba García-Fernández & Irene Galiana & Ana Perez-Villalba & Pablo Martí-Rodrigo & M. José Palop & Marcia Domínguez & Mar Orzáez & Félix Sancenón & Juan F., 2024. "A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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