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Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms

Author

Listed:
  • Caroline G. Atyeo

    (MIT, and Harvard
    Harvard University)

  • Lydia L. Shook

    (Harvard Medical School
    Massachusetts General Hospital)

  • Sara Brigida

    (Massachusetts General Hospital)

  • Rose M. Guzman

    (Harvard Medical School
    Massachusetts General Hospital)

  • Stepan Demidkin

    (Massachusetts General Hospital)

  • Cordelia Muir

    (Massachusetts General Hospital)

  • Babatunde Akinwunmi

    (Harvard Medical School)

  • Arantxa Medina Baez

    (Massachusetts General Hospital)

  • Maegan L. Sheehan

    (MIT, and Harvard)

  • Erin McSweeney

    (Massachusetts General Hospital)

  • Madeleine D. Burns

    (Harvard Medical School
    Massachusetts General Hospital
    Massachusetts General Hospital
    Harvard Medical School)

  • Ruhi Nayak

    (Massachusetts General Hospital)

  • Maya K. Kumar

    (Harvard Medical School)

  • Chinmay D. Patel

    (Harvard Medical School)

  • Allison Fialkowski

    (Massachusetts General Hospital
    Massachusetts General Hospital)

  • Dana Cvrk

    (Harvard Medical School)

  • Ilona T. Goldfarb

    (Harvard Medical School)

  • Lael M. Yonker

    (Massachusetts General Hospital
    Massachusetts General Hospital
    Harvard Medical School)

  • Alessio Fasano

    (Massachusetts General Hospital
    Massachusetts General Hospital
    Harvard Medical School)

  • Alejandro B. Balazs

    (MIT, and Harvard)

  • Michal A. Elovitz

    (University of Pennsylvania)

  • Kathryn J. Gray

    (Harvard Medical School)

  • Galit Alter

    (MIT, and Harvard)

  • Andrea G. Edlow

    (Harvard Medical School
    Massachusetts General Hospital)

Abstract

The availability of three COVID-19 vaccines in the United States provides an unprecedented opportunity to examine how vaccine platforms and timing of vaccination in pregnancy impact maternal and neonatal immunity. Here, we characterize the antibody profile after Ad26.COV2.S, mRNA-1273 or BNT162b2 vaccination in 158 pregnant individuals and evaluate transplacental antibody transfer by profiling maternal and umbilical cord blood in 175 maternal-neonatal dyads. These analyses reveal lower vaccine-induced functions and Fc receptor-binding after Ad26.COV2.S compared to mRNA vaccination and subtle advantages in titer and function with mRNA-1273 versus BN162b2. mRNA vaccines have higher titers and functions against SARS-CoV-2 variants of concern. First and third trimester vaccination results in enhanced maternal antibody-dependent NK-cell activation, cellular and neutrophil phagocytosis, and complement deposition relative to second trimester. Higher transplacental transfer ratios following first and second trimester vaccination may reflect placental compensation for waning maternal titers. These results provide novel insight into the impact of platform and trimester of vaccination on maternal humoral immune response and transplacental antibody transfer.

Suggested Citation

  • Caroline G. Atyeo & Lydia L. Shook & Sara Brigida & Rose M. Guzman & Stepan Demidkin & Cordelia Muir & Babatunde Akinwunmi & Arantxa Medina Baez & Maegan L. Sheehan & Erin McSweeney & Madeleine D. Bur, 2022. "Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31169-8
    DOI: 10.1038/s41467-022-31169-8
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    References listed on IDEAS

    as
    1. Galit Alter & Jingyou Yu & Jinyan Liu & Abishek Chandrashekar & Erica N. Borducchi & Lisa H. Tostanoski & Katherine McMahan & Catherine Jacob-Dolan & David R. Martinez & Aiquan Chang & Tochi Anioke & , 2021. "Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans," Nature, Nature, vol. 596(7871), pages 268-272, August.
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    Cited by:

    1. Elisabeth A. Murphy & Camila Guzman-Cardozo & Ashley C. Sukhu & Debby J. Parks & Malavika Prabhu & Iman Mohammed & Magdalena Jurkiewicz & Thomas J. Ketas & Sunidhi Singh & Marie Canis & Eva Bednarski , 2023. "SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Rafael R. G. Machado & Jordyn L. Walker & Dionna Scharton & Grace H. Rafael & Brooke M. Mitchell & Rachel A. Reyna & William M. Souza & Jianying Liu & David H. Walker & Jessica A. Plante & Kenneth S. , 2023. "Immunogenicity and efficacy of vaccine boosters against SARS-CoV-2 Omicron subvariant BA.5 in male Syrian hamsters," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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