IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-39989-y.html
   My bibliography  Save this article

SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates

Author

Listed:
  • Elisabeth A. Murphy

    (Weill Cornell Medicine)

  • Camila Guzman-Cardozo

    (The Rockefeller University)

  • Ashley C. Sukhu

    (New York Presbyterian/Weill Cornell Medical Center)

  • Debby J. Parks

    (The Rockefeller University)

  • Malavika Prabhu

    (Weill Cornell Medicine)

  • Iman Mohammed

    (Weill Cornell Medicine)

  • Magdalena Jurkiewicz

    (Weill Cornell Medicine)

  • Thomas J. Ketas

    (Weill Cornell Medicine)

  • Sunidhi Singh

    (Weill Cornell Medicine)

  • Marie Canis

    (The Rockefeller University)

  • Eva Bednarski

    (The Rockefeller University)

  • Alexis Hollingsworth

    (Weill Cornell Medicine)

  • Embree M. Thompson

    (Weill Cornell Medicine)

  • Dorothy Eng

    (New York Presbyterian/Weill Cornell Medical Center)

  • Paul D. Bieniasz

    (The Rockefeller University
    The Rockefeller University)

  • Laura E. Riley

    (Weill Cornell Medicine)

  • Theodora Hatziioannou

    (The Rockefeller University)

  • Yawei J. Yang

    (Weill Cornell Medicine
    New York Presbyterian/Weill Cornell Medical Center)

Abstract

The effects of heterogeneous infection, vaccination and boosting histories prior to and during pregnancy have not been extensively studied and are likely important for protection of neonates. We measure levels of spike binding antibodies in 4600 patients and their neonates with different vaccination statuses, with and without history of SARS-CoV-2 infection. We investigate neutralizing antibody activity against different SARS-CoV-2 variant pseudotypes in a subset of 259 patients and determined correlation between IgG levels and variant neutralizing activity. We further study the ability of maternal antibody and neutralizing measurements to predict neutralizing antibody activity in the umbilical cord blood of neonates. In this work, we show SARS-CoV-2 vaccination and boosting, especially in the setting of previous infection, leads to significant increases in antibody levels and neutralizing activity even against the recent omicron BA.1 and BA.5 variants in both pregnant patients and their neonates.

Suggested Citation

  • Elisabeth A. Murphy & Camila Guzman-Cardozo & Ashley C. Sukhu & Debby J. Parks & Malavika Prabhu & Iman Mohammed & Magdalena Jurkiewicz & Thomas J. Ketas & Sunidhi Singh & Marie Canis & Eva Bednarski , 2023. "SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39989-y
    DOI: 10.1038/s41467-023-39989-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-39989-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-39989-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Leander Witte & Viren A. Baharani & Fabian Schmidt & Zijun Wang & Alice Cho & Raphael Raspe & Camila Guzman-Cardozo & Frauke Muecksch & Marie Canis & Debby J. Park & Christian Gaebler & Marina Caskey , 2023. "Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Joshua Guedalia & Michal Lipschuetz & Ronit Calderon-Margalit & Sarah M. Cohen & Debra Goldman-Wohl & Tali Kaminer & Eli Melul & Galit Shefer & Yishai Sompolinsky & Asnat Walfisch & Simcha Yagel & Ofe, 2022. "Effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy: a national observational study in Israel," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    3. Caroline G. Atyeo & Lydia L. Shook & Sara Brigida & Rose M. Guzman & Stepan Demidkin & Cordelia Muir & Babatunde Akinwunmi & Arantxa Medina Baez & Maegan L. Sheehan & Erin McSweeney & Madeleine D. Bur, 2022. "Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Joshua Guedalia & Michal Lipschuetz & Adva Cahen-Peretz & Sarah M. Cohen & Yishai Sompolinsky & Galit Shefer & Eli Melul & Zivanit Ergaz-Shaltiel & Debra Goldman-Wohl & Simcha Yagel & Ronit Calderon-M, 2024. "Maternal hybrid immunity and risk of infant COVID-19 hospitalizations: national case-control study in Israel," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Rafael R. G. Machado & Jordyn L. Walker & Dionna Scharton & Grace H. Rafael & Brooke M. Mitchell & Rachel A. Reyna & William M. Souza & Jianying Liu & David H. Walker & Jessica A. Plante & Kenneth S. , 2023. "Immunogenicity and efficacy of vaccine boosters against SARS-CoV-2 Omicron subvariant BA.5 in male Syrian hamsters," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39989-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.