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Novel genetic loci associated with hippocampal volume

Author

Listed:
  • Derrek P. Hibar

    (Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California)

  • Hieab H. H. Adams

    (Erasmus University Medical Center
    Erasmus MC)

  • Neda Jahanshad

    (Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California)

  • Ganesh Chauhan

    (INSERM Unit U1219, University of Bordeaux)

  • Jason L. Stein

    (Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
    University of North Carolina (UNC))

  • Edith Hofer

    (Medical University Graz
    Institute of Medical Informatics, Statistics and Documentation, Medical University Graz)

  • Miguel E. Renteria

    (QIMR Berghofer Medical Research Institute)

  • Joshua C. Bis

    (Cardiovascular Health Research Unit, University of Washington)

  • Alejandro Arias-Vasquez

    (Radboud University Medical Center
    Radboud University Medical Center
    Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • M. Kamran Ikram

    (Erasmus University Medical Center
    Academic Medicine Research Institute, Duke-NUS Graduate Medical School
    Singapore Eye Research Institute, Singapore National Eye Centre
    Memory Aging & Cognition Centre (MACC), National University Health System)

  • Sylvane Desrivières

    (MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London)

  • Meike W. Vernooij

    (Erasmus University Medical Center
    Erasmus MC)

  • Lucija Abramovic

    (Brain Center Rudolf Magnus, UMC Utrecht)

  • Saud Alhusaini

    (Montreal Neurological Institute, McGill University
    The Royal College of Surgeons in Ireland)

  • Najaf Amin

    (Erasmus University Medical Center)

  • Micael Andersson

    (Umeå University)

  • Konstantinos Arfanakis

    (Illinois Institute of Technology
    Rush Alzheimer’s Disease Center, Rush University Medical Center
    Rush University Medical Center)

  • Benjamin S. Aribisala

    (Brain Research Imaging Centre, University of Edinburgh
    Lagos State University
    Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, University of Edinburgh)

  • Nicola J. Armstrong

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
    Mathematics and Statistics, Murdoch University)

  • Lavinia Athanasiu

    (NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
    NORMENT—KG Jebsen Centre, Oslo University Hospital)

  • Tomas Axelsson

    (Molecular Medicine and Science for Life Laboratory, Uppsala University)

  • Ashley H. Beecham

    (University of Miami, Miller School of Medicine
    John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine)

  • Alexa Beiser

    (Boston University School of Medicine
    Boston University School of Public Health
    Framingham Heart Study)

  • Manon Bernard

    (Hospital for Sick Children, University of Toronto)

  • Susan H. Blanton

    (University of Miami, Miller School of Medicine
    John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine)

  • Marc M. Bohlken

    (Brain Center Rudolf Magnus, UMC Utrecht)

  • Marco P. Boks

    (Brain Center Rudolf Magnus, UMC Utrecht)

  • Janita Bralten

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • Adam M. Brickman

    (Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Department of Neurology. Columbia University Medical Center
    G.H. Sergievsky Center)

  • Owen Carmichael

    (Pennington Biomedical Research Center)

  • M. Mallar Chakravarty

    (Cerebral Imaging Centre, Douglas Mental Health University Institute
    McGill University)

  • Qiang Chen

    (Lieber Institute for Brain Development)

  • Christopher R. K. Ching

    (Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
    UCLA School of Medicine)

  • Vincent Chouraki

    (Boston University School of Medicine
    Framingham Heart Study
    Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167—RID-AGE—Risk factors and molecular determinants of aging-related diseases)

  • Gabriel Cuellar-Partida

    (QIMR Berghofer Medical Research Institute)

  • Fabrice Crivello

    (IMN UMR5293, GIN, CNRS, CEA, University of Bordeaux)

  • Anouk Den Braber

    (Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center)

  • Nhat Trung Doan

    (NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo)

  • Stefan Ehrlich

    (Faculty of Medicine, TU Dresden
    Massachusetts General Hospital
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital)

  • Sudheer Giddaluru

    (NORMENT—KG Jebsen Centre for Psychosis Research, University of Bergen
    Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital)

  • Aaron L. Goldman

    (Lieber Institute for Brain Development)

  • Rebecca F. Gottesman

    (Johns Hopkins University School of Medicine)

  • Oliver Grimm

    (Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg)

  • Michael E. Griswold

    (University of Mississippi Medical Center)

  • Tulio Guadalupe

    (Max Planck Institute for Psycholinguistics
    International Max Planck Research School for Language Sciences)

  • Boris A. Gutman

    (Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California)

  • Johanna Hass

    (Faculty of Medicine of the TU Dresden)

  • Unn K. Haukvik

    (NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
    Diakonhjemmet Hospital)

  • David Hoehn

    (Max Planck Institute of Psychiatry)

  • Avram J. Holmes

    (Massachusetts General Hospital
    Yale University)

  • Martine Hoogman

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • Deborah Janowitz

    (University Medicine Greifswald)

  • Tianye Jia

    (MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London)

  • Kjetil N. Jørgensen

    (NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
    Diakonhjemmet Hospital)

  • Nazanin Karbalai

    (Max Planck Institute of Psychiatry)

  • Dalia Kasperaviciute

    (UCL Institute of Neurology, London, United Kingdom and Epilepsy Society
    Imperial College London)

  • Sungeun Kim

    (Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
    Center for Computational Biology and Bioinformatics, Indiana University School of Medicine
    Indiana Alzheimer Disease Center, Indiana University School of Medicine)

  • Marieke Klein

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • Bernd Kraemer

    (Section for Experimental Psychopathology and Neuroimaging, Heidelberg University)

  • Phil H. Lee

    (Massachusetts General Hospital
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital
    Harvard Medical School
    Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard)

  • David C. M. Liewald

    (Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh)

  • Lorna M. Lopez

    (Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh)

  • Michelle Luciano

    (Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh)

  • Christine Macare

    (MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London)

  • Andre F. Marquand

    (Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Donders Centre for Cognitive Neuroimaging, Radboud University)

  • Mar Matarin

    (UCL Institute of Neurology, London, United Kingdom and Epilepsy Society
    UCL Institute of Neurology)

  • Karen A. Mather

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales)

  • Manuel Mattheisen

    (Aarhus University
    The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
    Center for integrated Sequencing, iSEQ, Aarhus University)

  • David R. McKay

    (Yale University
    Olin Neuropsychiatric Research Center)

  • Yuri Milaneschi

    (EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest)

  • Susana Muñoz Maniega

    (Brain Research Imaging Centre, University of Edinburgh
    Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh)

  • Kwangsik Nho

    (Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
    Center for Computational Biology and Bioinformatics, Indiana University School of Medicine
    Indiana Alzheimer Disease Center, Indiana University School of Medicine)

  • Allison C. Nugent

    (Human Genetics Branch, National Institute of Mental Health Intramural Research Program)

  • Paul Nyquist

    (Johns Hopkins)

  • Loes M. Olde Loohuis

    (Center for Neurobehavioral Genetics, University of California)

  • Jaap Oosterlaan

    (VU University Amsterdam)

  • Martina Papmeyer

    (Royal Edinburgh Hospital, University of Edinburgh
    Translational Research Center, University Hospital of Psychiatry, University of Bern)

  • Lukas Pirpamer

    (Medical University Graz)

  • Benno Pütz

    (Max Planck Institute of Psychiatry)

  • Adaikalavan Ramasamy

    (UCL Institute of Neurology
    King’s College London
    The Jenner Institute Laboratories, University of Oxford)

  • Jennifer S. Richards

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Karakter Child and Adolescent Psychiatry University Center)

  • Shannon L. Risacher

    (Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
    Indiana Alzheimer Disease Center, Indiana University School of Medicine)

  • Roberto Roiz-Santiañez

    (University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL
    CIBERSAM (Centro Investigación Biomédica en Red Salud Mental))

  • Nanda Rommelse

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Karakter Child and Adolescent Psychiatry University Center)

  • Stefan Ropele

    (Medical University Graz)

  • Emma J. Rose

    (Psychosis Research Group, Trinity College)

  • Natalie A. Royle

    (Brain Research Imaging Centre, University of Edinburgh
    Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
    Centre for Clinical Brain Sciences, University of Edinburgh)

  • Tatjana Rundek

    (University of Miami, Miller School of Medicine
    University of Miami, Miller School of Medicine)

  • Philipp G. Sämann

    (Max Planck Institute of Psychiatry)

  • Arvin Saremi

    (Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California)

  • Claudia L. Satizabal

    (Boston University School of Medicine
    Framingham Heart Study)

  • Lianne Schmaal

    (Orygen, The National Centre of Excellence in Youth Mental Health
    Centre for Youth Mental Health, The University of Melbourne
    Neuroscience Campus Amsterdam, VU University Medical Center)

  • Andrew J. Schork

    (Multimodal Imaging Laboratory, University of California
    University of California)

  • Li Shen

    (Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
    Center for Computational Biology and Bioinformatics, Indiana University School of Medicine
    Indiana Alzheimer Disease Center, Indiana University School of Medicine)

  • Jean Shin

    (Hospital for Sick Children, University of Toronto)

  • Elena Shumskaya

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Donders Centre for Cognitive Neuroimaging, Radboud University)

  • Albert V. Smith

    (Icelandic Heart Association
    Faculty of Medicine, University of Iceland)

  • Emma Sprooten

    (Yale University
    Olin Neuropsychiatric Research Center
    Icahn School of Medicine at Mount Sinai)

  • Lachlan T. Strike

    (QIMR Berghofer Medical Research Institute
    Queensland Brain Institute, University of Queensland)

  • Alexander Teumer

    (Institute for Community Medicine, University Medicine Greifswald)

  • Diana Tordesillas-Gutierrez

    (CIBERSAM (Centro Investigación Biomédica en Red Salud Mental)
    Neuroimaging Unit, Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL)

  • Roberto Toro

    (Institut Pasteur)

  • Daniah Trabzuni

    (UCL Institute of Neurology
    King Faisal Specialist Hospital and Research Centre)

  • Stella Trompet

    (Leiden University Medical Center)

  • Dhananjay Vaidya

    (GeneSTAR Research Center, Johns Hopkins University School of Medicine)

  • Jeroen Van der Grond

    (Leiden University Medical Center)

  • Sven J. Van der Lee

    (Erasmus University Medical Center)

  • Dennis Van der Meer

    (University of Groningen, University Medical Center Groningen)

  • Marjolein M. J. Van Donkelaar

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • Kristel R. Van Eijk

    (Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht)

  • Theo G. M. Van Erp

    (University of California-Irvine)

  • Daan Van Rooij

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University
    University of Groningen, University Medical Center Groningen)

  • Esther Walton

    (Faculty of Medicine, TU Dresden
    Georgia State University)

  • Lars T. Westlye

    (NORMENT—KG Jebsen Centre, Oslo University Hospital
    Georgia State University)

  • Christopher D. Whelan

    (Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California
    The Royal College of Surgeons in Ireland)

  • Beverly G. Windham

    (NORMENT—KG Jebsen Centre, University of Oslo)

  • Anderson M. Winkler

    (Yale University
    University of Mississippi Medical Center)

  • Katharina Wittfeld

    (University Medicine Greifswald
    FMRIB Centre, University of Oxford)

  • Girma Woldehawariat

    (Human Genetics Branch, National Institute of Mental Health Intramural Research Program)

  • Christiane Wolf

    (German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald)

  • Thomas Wolfers

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • Lisa R. Yanek

    (GeneSTAR Research Center, Johns Hopkins University School of Medicine)

  • Jingyun Yang

    (Rush Alzheimer’s Disease Center, Rush University Medical Center
    University of Wuerzburg, Psychosomatics and Psychotherapy)

  • Alex Zijdenbos

    (Rush University Medical Center)

  • Marcel P. Zwiers

    (Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Donders Centre for Cognitive Neuroimaging, Radboud University)

  • Ingrid Agartz

    (NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
    Diakonhjemmet Hospital
    Biospective Inc, Montreal, Quebec, Canada)

  • Laura Almasy

    (Centre for Psychiatric Research, Karolinska Institutet
    South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
    Perelman School of Medicine, University of Pennsylvania)

  • David Ames

    (The Children’s Hospital of Philadelphia
    National Ageing Research Institute, Royal Melbourne Hospital)

  • Philippe Amouyel

    (Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167—RID-AGE—Risk factors and molecular determinants of aging-related diseases)

  • Ole A. Andreassen

    (NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
    NORMENT—KG Jebsen Centre, Oslo University Hospital)

  • Sampath Arepalli

    (Academic Unit for Psychiatry of Old Age, University of Melbourne)

  • Amelia A. Assareh

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales)

  • Sandra Barral

    (Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Department of Neurology. Columbia University Medical Center
    G.H. Sergievsky Center)

  • Mark E. Bastin

    (Brain Research Imaging Centre, University of Edinburgh
    Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
    Centre for Clinical Brain Sciences, University of Edinburgh)

  • Diane M. Becker

    (GeneSTAR Research Center, Johns Hopkins University School of Medicine)

  • James T. Becker

    (Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health)

  • David A. Bennett

    (Rush Alzheimer’s Disease Center, Rush University Medical Center
    University of Wuerzburg, Psychosomatics and Psychotherapy)

  • John Blangero

    (Centre for Psychiatric Research, Karolinska Institutet)

  • Hans van Bokhoven

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • Dorret I. Boomsma

    (Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center)

  • Henry Brodaty

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
    Neurology, and Psychology, University of Pittsburgh)

  • Rachel M. Brouwer

    (Brain Center Rudolf Magnus, UMC Utrecht)

  • Han G. Brunner

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Dementia Collaborative Research Centre—Assessment and Better Care, University of New South Wales)

  • Randy L. Buckner

    (Massachusetts General Hospital
    Maastricht University Medical Center)

  • Jan K. Buitelaar

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Karakter Child and Adolescent Psychiatry University Center)

  • Kazima B. Bulayeva

    (Center for Brain Science, Harvard University)

  • Wiepke Cahn

    (Brain Center Rudolf Magnus, UMC Utrecht)

  • Vince D. Calhoun

    (Dagestan State University
    The Mind Research Network & LBERI)

  • Dara M. Cannon

    (Human Genetics Branch, National Institute of Mental Health Intramural Research Program
    University of New Mexico)

  • Gianpiero L. Cavalleri

    (The Royal College of Surgeons in Ireland)

  • Ching-Yu Cheng

    (Academic Medicine Research Institute, Duke-NUS Graduate Medical School
    Singapore Eye Research Institute, Singapore National Eye Centre
    Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway)

  • Sven Cichon

    (Yong Loo Lin School of Medicine, National University of Singapore
    University of Basel
    Institute of Human Genetics, University of Bonn)

  • Mark R. Cookson

    (Academic Unit for Psychiatry of Old Age, University of Melbourne)

  • Aiden Corvin

    (Psychosis Research Group, Trinity College)

  • Benedicto Crespo-Facorro

    (University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL
    CIBERSAM (Centro Investigación Biomédica en Red Salud Mental))

  • Joanne E. Curran

    (Centre for Psychiatric Research, Karolinska Institutet)

  • Michael Czisch

    (Max Planck Institute of Psychiatry)

  • Anders M. Dale

    (Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich
    Center for Multimodal Imaging and Genetics, University of California)

  • Gareth E. Davies

    (Radiology, Psychiatry, and Cognitive Science, University of California)

  • Anton J. M. De Craen

    (Avera Institute for Human Genetics)

  • Eco J. C. De Geus

    (Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center)

  • Philip L. De Jager

    (Harvard Medical School
    Leiden University Medical Center
    Program in Translational NeuroPsychiatric Genomics, Brigham and Women’s Hospital
    Harvard Medical School)

  • Greig I. De Zubicaray

    (Broad Institute)

  • Ian J. Deary

    (Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh)

  • Stéphanie Debette

    (INSERM Unit U1219, University of Bordeaux
    Boston University School of Medicine
    Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT))

  • Charles DeCarli

    (Bordeaux University Hospital)

  • Norman Delanty

    (The Royal College of Surgeons in Ireland
    Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis)

  • Chantal Depondt

    (Beaumont Hospital)

  • Anita DeStefano

    (Boston University School of Public Health
    Framingham Heart Study)

  • Allissa Dillman

    (Academic Unit for Psychiatry of Old Age, University of Melbourne)

  • Srdjan Djurovic

    (NORMENT—KG Jebsen Centre for Psychosis Research, University of Bergen
    Hopital Erasme, Universite Libre de Bruxelles)

  • Gary Donohoe

    (Oslo University Hospital
    Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway)

  • Wayne C. Drevets

    (Human Genetics Branch, National Institute of Mental Health Intramural Research Program
    Neuropsychiatric Genetics Research Group, Trinity College Dublin)

  • Ravi Duggirala

    (Centre for Psychiatric Research, Karolinska Institutet)

  • Thomas D. Dyer

    (Centre for Psychiatric Research, Karolinska Institutet)

  • Christian Enzinger

    (Medical University Graz)

  • Susanne Erk

    (Janssen Research & Development, LLC)

  • Thomas Espeseth

    (NORMENT—KG Jebsen Centre, Oslo University Hospital
    Georgia State University)

  • Iryna O. Fedko

    (Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center)

  • Guillén Fernández

    (Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • Luigi Ferrucci

    (Charité - Universitätsmedizin Berlin, Campus Charité Mitte)

  • Simon E. Fisher

    (Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Max Planck Institute for Psycholinguistics)

  • Debra A. Fleischman

    (Rush Alzheimer’s Disease Center, Rush University Medical Center
    Intramural Research Program of the National Institute on Aging)

  • Ian Ford

    (Rush University Medical Center)

  • Myriam Fornage

    (Robertson Centre for Biostatistics, University of Glasgow)

  • Tatiana M. Foroud

    (Indiana Alzheimer Disease Center, Indiana University School of Medicine
    Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston)

  • Peter T. Fox

    (Medical and Molecular Genetics, Indiana University School of Medicine)

  • Clyde Francks

    (Donders Institute for Brain, Cognition and Behaviour, Radboud University
    Max Planck Institute for Psycholinguistics)

  • Masaki Fukunaga

    (University of Texas Health Science Center)

  • J. Raphael Gibbs

    (UCL Institute of Neurology
    Academic Unit for Psychiatry of Old Age, University of Melbourne)

  • David C. Glahn

    (Yale University
    Olin Neuropsychiatric Research Center)

  • Randy L. Gollub

    (Massachusetts General Hospital
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital
    Harvard Medical School)

  • Harald H. H. Göring

    (Centre for Psychiatric Research, Karolinska Institutet)

  • Robert C. Green

    (Harvard Medical School
    National Institute for Physiological Sciences)

  • Oliver Gruber

    (Section for Experimental Psychopathology and Neuroimaging, Heidelberg University)

  • Vilmundur Gudnason

    (Icelandic Heart Association
    Faculty of Medicine, University of Iceland)

  • Sebastian Guelfi

    (UCL Institute of Neurology)

  • Asta K. Håberg

    (Brigham and Women’s Hospital
    Faculty of Medicine, Norwegian University of Science and Technology (NTNU))

  • Narelle K. Hansell

    (QIMR Berghofer Medical Research Institute
    Queensland Brain Institute, University of Queensland)

  • John Hardy

    (UCL Institute of Neurology)

  • Catharina A. Hartman

    (University of Groningen, University Medical Center Groningen)

  • Ryota Hashimoto

    (St. Olav’s Hospital, Trondheim University Hospital
    Osaka University Graduate School of Medicine)

  • Katrin Hegenscheid

    (Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University)

  • Andreas Heinz

    (Janssen Research & Development, LLC)

  • Stephanie Le Hellard

    (NORMENT—KG Jebsen Centre for Psychosis Research, University of Bergen
    Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital)

  • Dena G. Hernandez

    (UCL Institute of Neurology
    Academic Unit for Psychiatry of Old Age, University of Melbourne
    Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald)

  • Dirk J. Heslenfeld

    (German Center for Neurodegenerative Diseases (DZNE))

  • Beng-Choon Ho

    (VU University Amsterdam)

  • Pieter J. Hoekstra

    (University of Groningen, University Medical Center Groningen)

  • Wolfgang Hoffmann

    (Institute for Community Medicine, University Medicine Greifswald
    FMRIB Centre, University of Oxford)

  • Albert Hofman

    (Harvard T.H. Chan School of Public Health)

  • Florian Holsboer

    (Max Planck Institute of Psychiatry
    University of Iowa)

  • Georg Homuth

    (Harvard T.H. Chan School of Public Health)

  • Norbert Hosten

    (Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University)

  • Jouke-Jan Hottenga

    (Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center)

  • Matthew Huentelman

    (HMNC Brain Health)

  • Hilleke E. Hulshoff Pol

    (Brain Center Rudolf Magnus, UMC Utrecht)

  • Masashi Ikeda

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald)

  • Clifford R. Jack Jr

    (Translational Genomics Research Institute)

  • Mark Jenkinson

    (University of Mississippi Medical Center)

  • Robert Johnson

    (Fujita Health University School of Medicine)

  • Erik G. Jönsson

    (NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
    Biospective Inc, Montreal, Quebec, Canada)

  • J. Wouter Jukema

    (Leiden University Medical Center)

  • René S. Kahn

    (Brain Center Rudolf Magnus, UMC Utrecht)

  • Ryota Kanai

    (Mayo Clinic
    NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School
    School of Psychology, University of Sussex)

  • Iwona Kloszewska

    (Institute of Cognitive Neuroscience, University College London)

  • David S. Knopman

    (Araya Brain Imaging)

  • Peter Kochunov

    (Medical University of Lodz)

  • John B. Kwok

    (Mayo Clinic
    Maryland Psychiatric Research Center, University of Maryland School of Medicine)

  • Stephen M. Lawrie

    (Royal Edinburgh Hospital, University of Edinburgh)

  • Hervé Lemaître

    (Neuroscience Research Australia)

  • Xinmin Liu

    (Human Genetics Branch, National Institute of Mental Health Intramural Research Program
    School of Medical Sciences, UNSW)

  • Dan L. Longo

    (University Paris-Sud, Université Paris-Saclay, University Paris Descartes
    University Paris-Sud, Université Paris-Saclay, University Paris Descartes)

  • Oscar L. Lopez

    (Columbia University Medical Center)

  • Simon Lovestone

    (Laboratory of Genetics, National Institute on Aging, National Institutes of Health
    University of Pittsburgh)

  • Oliver Martinez

    (Bordeaux University Hospital)

  • Jean-Luc Martinot

    (Neuroscience Research Australia)

  • Venkata S. Mattay

    (Lieber Institute for Brain Development
    Johns Hopkins University School of Medicine
    University of Oxford)

  • Colm McDonald

    (University of New Mexico)

  • Andrew M. McIntosh

    (Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
    Royal Edinburgh Hospital, University of Edinburgh)

  • Francis J. McMahon

    (Human Genetics Branch, National Institute of Mental Health Intramural Research Program)

  • Katie L. McMahon

    (Johns Hopkins University School of Medicine)

  • Patrizia Mecocci

    (Centre for Advanced Imaging, University of Queensland)

  • Ingrid Melle

    (NORMENT—KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo
    NORMENT—KG Jebsen Centre, Oslo University Hospital)

  • Andreas Meyer-Lindenberg

    (Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg)

  • Sebastian Mohnke

    (Janssen Research & Development, LLC)

  • Grant W. Montgomery

    (QIMR Berghofer Medical Research Institute)

  • Derek W. Morris

    (Oslo University Hospital)

  • Thomas H. Mosley

    (NORMENT—KG Jebsen Centre, University of Oslo)

  • Thomas W. Mühleisen

    (University of Basel
    Institute of Human Genetics, University of Bonn)

  • Bertram Müller-Myhsok

    (Max Planck Institute of Psychiatry
    Section of Gerontology and Geriatrics, University of Perugia
    Munich Cluster for Systems Neurology (SyNergy))

  • Michael A. Nalls

    (Academic Unit for Psychiatry of Old Age, University of Melbourne)

  • Matthias Nauck

    (University of Liverpool, Institute of Translational Medicine
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald)

  • Thomas E. Nichols

    (University of Mississippi Medical Center
    German Center for Cardiovascular Research (DZHK e.V.), partner site Greifswald)

  • Wiro J. Niessen

    (Erasmus MC
    University of Warwick
    Department of Medical Informatics Erasmus MC)

  • Markus M. Nöthen

    (University of Basel
    Faculty of Applied Sciences, Delft University of Technology)

  • Lars Nyberg

    (Umeå University)

  • Kazutaka Ohi

    (St. Olav’s Hospital, Trondheim University Hospital)

  • Rene L. Olvera

    (Medical and Molecular Genetics, Indiana University School of Medicine)

  • Roel A. Ophoff

    (Brain Center Rudolf Magnus, UMC Utrecht
    Center for Neurobehavioral Genetics, University of California)

  • Massimo Pandolfo

    (Beaumont Hospital)

  • Tomas Paus

    (Life & Brain Center, University of Bonn
    Rotman Research Institute, University of Toronto
    University of Toronto)

  • Zdenka Pausova

    (Hospital for Sick Children, University of Toronto
    Child Mind Institute)

  • Brenda W. J. H. Penninx

    (Neuroscience Campus Amsterdam, VU University Medical Center)

  • G. Bruce Pike

    (University of Toronto
    University of Calgary)

  • Steven G. Potkin

    (University of California-Irvine)

  • Bruce M. Psaty

    (University of Calgary)

  • Simone Reppermund

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
    Medicine and Health Services, University of Washington, Seattle, WA, USA Group Health Research Institute, Group Health)

  • Marcella Rietschel

    (Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg)

  • Joshua L. Roffman

    (Massachusetts General Hospital)

  • Nina Romanczuk-Seiferth

    (Janssen Research & Development, LLC)

  • Jerome I. Rotter

    (School of Psychiatry, University of New South Wales)

  • Mina Ryten

    (UCL Institute of Neurology
    King’s College London)

  • Ralph L. Sacco

    (John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine
    University of Miami, Miller School of Medicine
    University of Miami, Miller School of Medicine
    Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center)

  • Perminder S. Sachdev

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
    Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine)

  • Andrew J. Saykin

    (Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine
    Indiana Alzheimer Disease Center, Indiana University School of Medicine
    Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston)

  • Reinhold Schmidt

    (Medical University Graz)

  • Helena Schmidt

    (Neuropsychiatric Institute, Prince of Wales Hospital)

  • Peter R. Schofield

    (Mayo Clinic
    Maryland Psychiatric Research Center, University of Maryland School of Medicine)

  • Sigurdur Sigursson

    (Icelandic Heart Association)

  • Andrew Simmons

    (Institute of Molecular Biology and Biochemistry, Medical University Graz
    Institute of Psychiatry, King’s College London
    Biomedical Research Centre for Mental Health, King’s College London)

  • Andrew Singleton

    (Academic Unit for Psychiatry of Old Age, University of Melbourne)

  • Sanjay M. Sisodiya

    (UCL Institute of Neurology, London, United Kingdom and Epilepsy Society)

  • Colin Smith

    (Biomedical Research Unit for Dementia, King’s College London)

  • Jordan W. Smoller

    (Massachusetts General Hospital
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital
    Harvard Medical School
    Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard)

  • Hilkka Soininen

    (MRC Edinburgh Brain Bank, University of Edinburgh, Centre for Clinical Brain Sciences
    Institute of Clinical Medicine, Neurology, University of Eastern Finland)

  • Vidar M. Steen

    (NORMENT—KG Jebsen Centre for Psychosis Research, University of Bergen
    Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital)

  • David J. Stott

    (Neurocentre Neurology, Kuopio University Hospital)

  • Jessika E. Sussmann

    (Royal Edinburgh Hospital, University of Edinburgh)

  • Anbupalam Thalamuthu

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales)

  • Arthur W. Toga

    (Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow)

  • Bryan J. Traynor

    (Academic Unit for Psychiatry of Old Age, University of Melbourne)

  • Juan Troncoso

    (Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine of the University of Southern California)

  • Magda Tsolaki

    (Johns Hopkins University)

  • Christophe Tzourio

    (INSERM Unit U1219, University of Bordeaux
    "G. Papanicolaou", Hospital, Aristotle University of Thessaloniki)

  • Andre G. Uitterlinden

    (Erasmus University Medical Center
    Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR1219)

  • Maria C. Valdés Hernández

    (Brain Research Imaging Centre, University of Edinburgh
    Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
    Centre for Clinical Brain Sciences, University of Edinburgh)

  • Marcel Van der Brug

    (Erasmus MC)

  • Aad van der Lugt

    (Erasmus MC)

  • Nic J. A. van der Wee

    (Genentech Inc.)

  • Neeltje E. M. Van Haren

    (Brain Center Rudolf Magnus, UMC Utrecht)

  • Dennis van ’t Ent

    (Biological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center)

  • Marie-Jose Van Tol

    (Leiden University Medical Center)

  • Badri N. Vardarajan

    (Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Department of Neurology. Columbia University Medical Center
    G.H. Sergievsky Center)

  • Bruno Vellas

    (University of Groningen, University Medical Center Groningen)

  • Dick J. Veltman

    (Neuroscience Campus Amsterdam, VU University Medical Center)

  • Henry Völzke

    (Institute for Community Medicine, University Medicine Greifswald)

  • Henrik Walter

    (Janssen Research & Development, LLC)

  • Joanna M. Wardlaw

    (Brain Research Imaging Centre, University of Edinburgh
    Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
    Centre for Clinical Brain Sciences, University of Edinburgh)

  • Thomas H. Wassink

    (INSERM U1027, University of Toulouse)

  • Michael E. Weale

    (King’s College London)

  • Daniel R. Weinberger

    (Lieber Institute for Brain Development
    Carver College of Medicine, University of Iowa)

  • Michael W. Weiner

    (Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Wei Wen

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
    Evelyn F. McKnight Brain Institute, University of Miami, Miller School of Medicine)

  • Eric Westman

    (Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California)

  • Tonya White

    (Erasmus MC
    Care Sciences and Society, Karolinska Institutet)

  • Tien Y. Wong

    (Academic Medicine Research Institute, Duke-NUS Graduate Medical School
    Singapore Eye Research Institute, Singapore National Eye Centre
    Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway)

  • Clinton B. Wright

    (University of Miami, Miller School of Medicine
    University of Miami, Miller School of Medicine
    Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center)

  • Ronald H. Zielke

    (Fujita Health University School of Medicine)

  • Alan B. Zonderman

    (Erasmus MC-Sophia Children’s Hospital)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Cornelia M. Van Duijn

    (Erasmus University Medical Center)

  • Margaret J. Wright

    (Queensland Brain Institute, University of Queensland
    Johns Hopkins University School of Medicine)

  • W. T. Longstreth

    (Laboratory of Epidemiology & Population Sciences, National Institute on Aging, National Institutes of Health)

  • Gunter Schumann

    (MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London)

  • Hans J. Grabe

    (University Medicine Greifswald)

  • Barbara Franke

    (Radboud University Medical Center
    Radboud University Medical Center
    Donders Institute for Brain, Cognition and Behaviour, Radboud University)

  • Lenore J. Launer

    (University of Washington, 325 Ninth Avenue, Seattle, Washington 98104-2420, USA)

  • Sarah E. Medland

    (QIMR Berghofer Medical Research Institute)

  • Sudha Seshadri

    (Boston University School of Medicine
    Framingham Heart Study)

  • Paul M. Thompson

    (Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California)

  • M. Arfan Ikram

    (Erasmus University Medical Center
    Erasmus MC
    Intramural Research Program, NIA, NIH)

Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease (rg=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Suggested Citation

  • Derrek P. Hibar & Hieab H. H. Adams & Neda Jahanshad & Ganesh Chauhan & Jason L. Stein & Edith Hofer & Miguel E. Renteria & Joshua C. Bis & Alejandro Arias-Vasquez & M. Kamran Ikram & Sylvane Desriviè, 2017. "Novel genetic loci associated with hippocampal volume," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms13624
    DOI: 10.1038/ncomms13624
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    Cited by:

    1. Pyunggang Kim & Jinah Park & Dong-Joon Lee & Seiya Mizuno & Masahiro Shinohara & Chang Pyo Hong & Yealeen Jeong & Rebecca Yun & Hyeyeon Park & Sujin Park & Kyung-Min Yang & Min-Jung Lee & Seung Pil Ja, 2022. "Mast4 determines the cell fate of MSCs for bone and cartilage development," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Michael Wainberg & Natalie J. Forde & Salim Mansour & Isabel Kerrebijn & Sarah E. Medland & Colin Hawco & Shreejoy J. Tripathy, 2024. "Genetic architecture of the structural connectome," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Shahram Bahrami & Kaja Nordengen & Alexey A. Shadrin & Oleksandr Frei & Dennis Meer & Anders M. Dale & Lars T. Westlye & Ole A. Andreassen & Tobias Kaufmann, 2022. "Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    4. Thomas S. Wingo & Yue Liu & Ekaterina S. Gerasimov & Selina M. Vattathil & Meghan E. Wynne & Jiaqi Liu & Adriana Lori & Victor Faundez & David A. Bennett & Nicholas T. Seyfried & Allan I. Levey & Aliz, 2022. "Shared mechanisms across the major psychiatric and neurodegenerative diseases," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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