IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25174-6.html
   My bibliography  Save this article

Rational design of pyrrole derivatives with aggregation-induced phosphorescence characteristics for time-resolved and two-photon luminescence imaging

Author

Listed:
  • Jianhui Yang

    (Beijing Institute of Technology)

  • Yahui Zhang

    (School of Life Science, Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology)

  • Xinghui Wu

    (Beijing Institute of Technology)

  • Wenbo Dai

    (Beijing Institute of Technology)

  • Dan Chen

    (Cancer Hospital of China Medical University, Liaoning Cancer Hospital)

  • Jianbing Shi

    (Beijing Institute of Technology)

  • Bin Tong

    (Beijing Institute of Technology)

  • Qian Peng

    (University of Chinese Academy of Sciences)

  • Haiyan Xie

    (School of Life Science, Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology)

  • Zhengxu Cai

    (Beijing Institute of Technology)

  • Yuping Dong

    (Beijing Institute of Technology)

  • Xin Zhang

    (Cancer Hospital of China Medical University, Liaoning Cancer Hospital)

Abstract

Pure organic room-temperature phosphorescent (RTP) materials have been suggested to be promising bioimaging materials due to their good biocompatibility and long emission lifetime. Herein, we report a class of RTP materials. These materials are developed through the simple introduction of an aromatic carbonyl to a tetraphenylpyrrole molecule and also exhibit aggregation-induced emission (AIE) properties. These molecules show non-emission in solution and purely phosphorescent emission in the aggregated state, which are desirable properties for biological imaging. Highly crystalline nanoparticles can be easily fabricated with a long emission lifetime (20 μs), which eliminate background fluorescence interference from cells and tissues. The prepared nanoparticles demonstrate two-photon absorption characteristics and can be excited by near infrared (NIR) light, making them promising materials for deep-tissue optical imaging. This integrated aggregation-induced phosphorescence (AIP) strategy diversifies the existing pool of bioimaging agents to inspire the development of bioprobes in the future.

Suggested Citation

  • Jianhui Yang & Yahui Zhang & Xinghui Wu & Wenbo Dai & Dan Chen & Jianbing Shi & Bin Tong & Qian Peng & Haiyan Xie & Zhengxu Cai & Yuping Dong & Xin Zhang, 2021. "Rational design of pyrrole derivatives with aggregation-induced phosphorescence characteristics for time-resolved and two-photon luminescence imaging," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25174-6
    DOI: 10.1038/s41467-021-25174-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25174-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-25174-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xiao Wang & Wenjing Sun & Huifang Shi & Huili Ma & Guowei Niu & Yuxin Li & Jiahuan Zhi & Xiaokang Yao & Zhicheng Song & Lei Chen & Shi Li & Guohui Yang & Zixing Zhou & Yixiao He & Shuli Qu & Min Wu & , 2022. "Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Tian Tian & Yuxuan Fang & Wenhui Wang & Meifang Yang & Ying Tan & Chuan Xu & Shuo Zhang & Yuxin Chen & Mingyi Xu & Bin Cai & Wu-Qiang Wu, 2023. "Durable organic nonlinear optical membranes for thermotolerant lightings and in vivo bioimaging," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Gang Xu & Chengwei Li & Chen Chi & Luyan Wu & Yanyan Sun & Jian Zhao & Xing-Hua Xia & Shaohua Gou, 2022. "A supramolecular photosensitizer derived from an Arene-Ru(II) complex self-assembly for NIR activated photodynamic and photothermal therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25174-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.