IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30649-1.html
   My bibliography  Save this article

Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

Author

Listed:
  • Juanjie Tang

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Tanya Novak

    (Boston Children’s Hospital
    Harvard Medical School)

  • Julian Hecker

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Gabrielle Grubbs

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Fatema Tuz Zahra

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Lorenza Bellusci

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Sara Pourhashemi

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Janet Chou

    (Boston Children’s Hospital and Harvard Medical School
    Boston Children’s Hospital, Harvard Medical School)

  • Kristin Moffitt

    (Boston Children’s Hospital and Harvard Medical School
    Boston Children’s Hospital)

  • Natasha B. Halasa

    (Vanderbilt University Medical Center)

  • Stephanie P. Schwartz

    (University of North Carolina at Chapel Hill Children’s Hospital)

  • Tracie C. Walker

    (University of North Carolina at Chapel Hill Children’s Hospital)

  • Keiko M. Tarquinio

    (Emory University School of Medicine, Children’s Healthcare of Atlanta)

  • Matt S. Zinter

    (University of California, San Francisco)

  • Mary A. Staat

    (Cincinnati Children’s Hospital Medical Center)

  • Shira J. Gertz

    (Cooperman Barnabas Medical Center)

  • Natalie Z. Cvijanovich

    (UCSF Benioff Children’s Hospital Oakland)

  • Jennifer E. Schuster

    (Children’s Mercy Kansas City)

  • Laura L. Loftis

    (Baylor College of Medicine)

  • Bria M. Coates

    (Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago)

  • Elizabeth H. Mack

    (Medical University of South Carolina)

  • Katherine Irby

    (Arkansas Children’s Hospital)

  • Julie C. Fitzgerald

    (The University of Pennsylvania Perelman School of Medicine)

  • Courtney M. Rowan

    (Indiana University School of Medicine, Riley Hospital for Children)

  • Michele Kong

    (University of Alabama at Birmingham)

  • Heidi R. Flori

    (Mott Children’s Hospital and University of Michigan)

  • Aline B. Maddux

    (University of Colorado School of Medicine and Children’s Hospital Colorado)

  • Steven L. Shein

    (Rainbow Babies and Children’s Hospital)

  • Hillary Crandall

    (University of Utah)

  • Janet R. Hume

    (University of Minnesota Masonic Children’s Hospital)

  • Charlotte V. Hobbs

    (University of Mississippi Medical Center)

  • Adriana H. Tremoulet

    (UCSD School of Medicine)

  • Chisato Shimizu

    (UCSD School of Medicine)

  • Jane C. Burns

    (UCSD School of Medicine)

  • Sabrina R. Chen

    (Boston Children’s Hospital)

  • Hye Kyung Moon

    (Boston Children’s Hospital)

  • Christoph Lange

    (Harvard T.H. Chan School of Public Health)

  • Adrienne G. Randolph

    (Boston Children’s Hospital
    Harvard Medical School
    Boston Children’s Hospital and Harvard Medical School)

  • Surender Khurana

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

Abstract

Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing capacity against SARS-CoV-2 Alpha, Beta, Gamma, Delta and Omicron variants by age-stratified analyses ( 5 years of age. As expected, convalescent pediatric COVID-19 and MIS-C cohorts demonstrate higher neutralization titers than hospitalized acute COVID-19 patients. Overall, children and adolescents show some loss of cross-neutralization against all variants, with the most pronounced loss against Omicron. In contrast to SARS-CoV-2 infection, children vaccinated twice demonstrated higher titers against Alpha, Beta, Gamma, Delta and Omicron. These findings can influence transmission, re-infection and the clinical disease outcome from emerging SARS-CoV-2 variants and supports the need for vaccination in children.

Suggested Citation

  • Juanjie Tang & Tanya Novak & Julian Hecker & Gabrielle Grubbs & Fatema Tuz Zahra & Lorenza Bellusci & Sara Pourhashemi & Janet Chou & Kristin Moffitt & Natasha B. Halasa & Stephanie P. Schwartz & Trac, 2022. "Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30649-1
    DOI: 10.1038/s41467-022-30649-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30649-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30649-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Masahiro Yoshida & Kaylee B. Worlock & Ni Huang & Rik G. H. Lindeboom & Colin R. Butler & Natsuhiko Kumasaka & Cecilia Dominguez Conde & Lira Mamanova & Liam Bolt & Laura Richardson & Krzysztof Polans, 2022. "Local and systemic responses to SARS-CoV-2 infection in children and adults," Nature, Nature, vol. 602(7896), pages 321-327, February.
    2. Juanjie Tang & Supriya Ravichandran & Youri Lee & Gabrielle Grubbs & Elizabeth M. Coyle & Laura Klenow & Hollie Genser & Hana Golding & Surender Khurana, 2021. "Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alexander C. Dowell & Tara Lancaster & Rachel Bruton & Georgina Ireland & Christopher Bentley & Panagiota Sylla & Jianmin Zuo & Sam Scott & Azar Jadir & Jusnara Begum & Thomas Roberts & Christine Step, 2023. "Immunological imprinting of humoral immunity to SARS-CoV-2 in children," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Lorenza Bellusci & Gabrielle Grubbs & Shaimaa Sait & Lael M. Yonker & Adrienne G. Randolph & Tanya Novak & Takuma Kobayashi & Surender Khurana, 2023. "Neutralization of SARS-CoV-2 Omicron BQ.1, BQ.1.1 and XBB.1 variants following SARS-CoV-2 infection or vaccination in children," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Meng Yu & Afandi Charles & Alberto Cagigi & Wanda Christ & Björn Österberg & Sara Falck-Jones & Lida Azizmohammadi & Eric Åhlberg & Ryan Falck-Jones & Julia Svensson & Mu Nie & Anna Warnqvist & Fredri, 2023. "Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Lorenza Bellusci & Gabrielle Grubbs & Shaimaa Sait & Lael M. Yonker & Adrienne G. Randolph & Tanya Novak & Takuma Kobayashi & Surender Khurana, 2023. "Neutralization of SARS-CoV-2 Omicron BQ.1, BQ.1.1 and XBB.1 variants following SARS-CoV-2 infection or vaccination in children," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Scott R. Tyler & Daniel Lozano-Ojalvo & Ernesto Guccione & Eric E. Schadt, 2024. "Anti-correlated feature selection prevents false discovery of subpopulations in scRNAseq," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Quy Xiao Xuan Lin & Deepa Rajagopalan & Akshamal M. Gamage & Le Min Tan & Prasanna Nori Venkatesh & Wharton O. Y. Chan & Dilip Kumar & Ragini Agrawal & Yao Chen & Siew-Wai Fong & Amit Singh & Louisa J, 2024. "Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Alessia Raineri & Thomas Radtke & Sonja Rueegg & Sarah R. Haile & Dominik Menges & Tala Ballouz & Agne Ulyte & Jan Fehr & Daniel L. Cornejo & Giuseppe Pantaleo & Céline Pellaton & Craig Fenwick & Milo, 2023. "Persistent humoral immune response in youth throughout the COVID-19 pandemic: prospective school-based cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Alexander C. Dowell & Tara Lancaster & Rachel Bruton & Georgina Ireland & Christopher Bentley & Panagiota Sylla & Jianmin Zuo & Sam Scott & Azar Jadir & Jusnara Begum & Thomas Roberts & Christine Step, 2023. "Immunological imprinting of humoral immunity to SARS-CoV-2 in children," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    7. Tabea M. Eser & Olga Baranov & Manuel Huth & Mohammed I. M. Ahmed & Flora Deák & Kathrin Held & Luming Lin & Kami Pekayvaz & Alexander Leunig & Leo Nicolai & Georgios Pollakis & Marcus Buggert & David, 2023. "Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    8. Asmaa Hachim & Haogao Gu & Otared Kavian & Masashi Mori & Mike Y. W. Kwan & Wai Hung Chan & Yat Sun Yau & Susan S. Chiu & Owen T. Y. Tsang & David S. C. Hui & Chris K. P. Mok & Fionn N. L. Ma & Eric H, 2022. "SARS-CoV-2 accessory proteins reveal distinct serological signatures in children," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    9. Yvonne M. Mueller & Thijs J. Schrama & Rik Ruijten & Marco W. J. Schreurs & Dwin G. B. Grashof & Harmen J. G. van de Werken & Giovanna Jona Lasinio & Daniel Álvarez-Sierra & Caoimhe H. Kiernan & Melis, 2022. "Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    10. Lorenza Bellusci & Gabrielle Grubbs & Fatema Tuz Zahra & David Forgacs & Hana Golding & Ted M. Ross & Surender Khurana, 2022. "Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA.1, BA.2 and BA.3 following third mRNA vaccination," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    11. Andreas Fønss Møller & Jesper Grud Skat Madsen, 2023. "JOINTLY: interpretable joint clustering of single-cell transcriptomes," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30649-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.