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Origin and dispersal history of Hepatitis B virus in Eastern Eurasia

Author

Listed:
  • Bing Sun

    (Jilin University)

  • Aida Andrades Valtueña

    (Max Planck Institute for Evolutionary Anthropology)

  • Arthur Kocher

    (Max Planck Institute for Evolutionary Anthropology
    Max Planck Institute for the Science of Human History)

  • Shizhu Gao

    (Jilin University)

  • Chunxiang Li

    (Jilin University)

  • Shuang Fu

    (Jilin University)

  • Fan Zhang

    (Jilin University)

  • Pengcheng Ma

    (Jilin University)

  • Xuan Yang

    (Jilin University)

  • Yulan Qiu

    (Jilin University)

  • Quanchao Zhang

    (Jilin University)

  • Jian Ma

    (Northwest University)

  • Shan Chen

    (Liaoning University)

  • Xiaoming Xiao

    (Liaoning University)

  • Sodnomjamts Damchaabadgar

    (Institute of Archaeology Mongolian Academy of Sciences)

  • Fajun Li

    (Sun Yat-sen University)

  • Alexey Kovalev

    (Institute of Archaeology of Russian Academy of Sciences)

  • Chunbai Hu

    (Inner Mongolia Autonomous Region)

  • Xianglong Chen

    (Chinese Academy of Social Sciences)

  • Lixin Wang

    (Jilin University)

  • Wenying Li

    (Xinjiang Institute of Cultural Relics and Archaeology)

  • Yawei Zhou

    (Zhengzhou University)

  • Hong Zhu

    (Jilin University)

  • Johannes Krause

    (Max Planck Institute for Evolutionary Anthropology)

  • Alexander Herbig

    (Max Planck Institute for Evolutionary Anthropology)

  • Yinqiu Cui

    (Jilin University)

Abstract

Hepatitis B virus is a globally distributed pathogen and the history of HBV infection in humans predates 10000 years. However, long-term evolutionary history of HBV in Eastern Eurasia remains elusive. We present 34 ancient HBV genomes dating between approximately 5000 to 400 years ago sourced from 17 sites across Eastern Eurasia. Ten sequences have full coverage, and only two sequences have less than 50% coverage. Our results suggest a potential origin of genotypes B and D in Eastern Asia. We observed a higher level of HBV diversity within Eastern Eurasia compared to Western Eurasia between 5000 and 3000 years ago, characterized by the presence of five different genotypes (A, B, C, D, WENBA), underscoring the significance of human migrations and interactions in the spread of HBV. Our results suggest the possibility of a transition from non-recombinant subgenotypes (B1, B5) to recombinant subgenotypes (B2 - B4). This suggests a shift in epidemiological dynamics within Eastern Eurasia over time. Here, our study elucidates the regional origins of prevalent genotypes and shifts in viral subgenotypes over centuries.

Suggested Citation

  • Bing Sun & Aida Andrades Valtueña & Arthur Kocher & Shizhu Gao & Chunxiang Li & Shuang Fu & Fan Zhang & Pengcheng Ma & Xuan Yang & Yulan Qiu & Quanchao Zhang & Jian Ma & Shan Chen & Xiaoming Xiao & So, 2024. "Origin and dispersal history of Hepatitis B virus in Eastern Eurasia," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47358-6
    DOI: 10.1038/s41467-024-47358-6
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    1. Peter Barros Damgaard & Nina Marchi & Simon Rasmussen & Michael Peyrot & Gabriel Renaud & Thorfinn Korneliussen & J. Victor Moreno-Mayar & Mikkel Winther Pedersen & Amy Goldberg & Emma Usmanova & Nurb, 2018. "Author Correction: 137 ancient human genomes from across the Eurasian steppes," Nature, Nature, vol. 563(7729), pages 16-16, November.
    2. Iosif Lazaridis & Dani Nadel & Gary Rollefson & Deborah C. Merrett & Nadin Rohland & Swapan Mallick & Daniel Fernandes & Mario Novak & Beatriz Gamarra & Kendra Sirak & Sarah Connell & Kristin Stewards, 2016. "Genomic insights into the origin of farming in the ancient Near East," Nature, Nature, vol. 536(7617), pages 419-424, August.
    3. Fan Zhang & Chao Ning & Ashley Scott & Qiaomei Fu & Rasmus Bjørn & Wenying Li & Dong Wei & Wenjun Wang & Linyuan Fan & Idilisi Abuduresule & Xingjun Hu & Qiurong Ruan & Alipujiang Niyazi & Guanghui Do, 2021. "The genomic origins of the Bronze Age Tarim Basin mummies," Nature, Nature, vol. 599(7884), pages 256-261, November.
    4. Barbara Muhlemann & Terry C. Jones & Peter Barros Damgaard & Morten E. Allentoft & Irina Shevnina & Andrey Logvin & Emma Usmanova & Irina P. Panyushkina & Bazartseren Boldgiv & Tsevel Bazartseren & Ka, 2018. "Author Correction: Ancient hepatitis B viruses from the Bronze Age to the Medieval period," Nature, Nature, vol. 562(7726), pages 4-4, October.
    5. Thiseas C. Lamnidis & Kerttu Majander & Choongwon Jeong & Elina Salmela & Anna Wessman & Vyacheslav Moiseyev & Valery Khartanovich & Oleg Balanovsky & Matthias Ongyerth & Antje Weihmann & Antti Sajant, 2018. "Ancient Fennoscandian genomes reveal origin and spread of Siberian ancestry in Europe," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    6. Barbara Mühlemann & Terry C. Jones & Peter de Barros Damgaard & Morten E. Allentoft & Irina Shevnina & Andrey Logvin & Emma Usmanova & Irina P. Panyushkina & Bazartseren Boldgiv & Tsevel Bazartseren &, 2018. "Ancient hepatitis B viruses from the Bronze Age to the Medieval period," Nature, Nature, vol. 557(7705), pages 418-423, May.
    7. Liu, Xinru, 2010. "The Silk Road in World History," OUP Catalogue, Oxford University Press, number 9780195338102.
    8. Chao Ning & Tianjiao Li & Ke Wang & Fan Zhang & Tao Li & Xiyan Wu & Shizhu Gao & Quanchao Zhang & Hai Zhang & Mark J. Hudson & Guanghui Dong & Sihao Wu & Yanming Fang & Chen Liu & Chunyan Feng & Wei L, 2020. "Ancient genomes from northern China suggest links between subsistence changes and human migration," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
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