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Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys

Author

Listed:
  • Xindong Song

    (Johns Hopkins University School of Medicine)

  • Yueqi Guo

    (Johns Hopkins University School of Medicine)

  • Hongbo Li

    (Johns Hopkins University School of Medicine)

  • Chenggang Chen

    (Johns Hopkins University School of Medicine)

  • Jong Hoon Lee

    (Johns Hopkins University School of Medicine)

  • Yang Zhang

    (Johns Hopkins University School of Medicine)

  • Zachary Schmidt

    (Johns Hopkins University School of Medicine)

  • Xiaoqin Wang

    (Johns Hopkins University School of Medicine)

Abstract

The primate cerebral cortex is organized into specialized areas representing different modalities and functions along a continuous surface. The functional maps across the cortex, however, are often investigated a single modality at a time (e.g., audition or vision). To advance our understanding of the complex landscape of primate cortical functions, here we develop a polarization-gated wide-field optical imaging method for measuring cortical functions through the un-thinned intact skull in awake marmoset monkeys (Callithrix jacchus), a primate species featuring a smooth cortex. Using this method, adjacent auditory, visual, and somatosensory cortices are noninvasively parcellated in individual subjects with detailed tonotopy, retinotopy, and somatotopy. An additional pure-tone-responsive tonotopic gradient is discovered in auditory cortex and a face-patch sensitive to motion in the lower-center visual field is localized near an auditory region representing frequencies of conspecific vocalizations. This through-skull landscape-mapping approach provides new opportunities for understanding how the primate cortex is organized and coordinated to enable real-world behaviors.

Suggested Citation

  • Xindong Song & Yueqi Guo & Hongbo Li & Chenggang Chen & Jong Hoon Lee & Yang Zhang & Zachary Schmidt & Xiaoqin Wang, 2022. "Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29864-7
    DOI: 10.1038/s41467-022-29864-7
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    References listed on IDEAS

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    1. Lauri Nurminen & Sam Merlin & Maryam Bijanzadeh & Frederick Federer & Alessandra Angelucci, 2018. "Top-down feedback controls spatial summation and response amplitude in primate visual cortex," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    2. Yevgeniy B. Sirotin & Aniruddha Das, 2009. "Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity," Nature, Nature, vol. 457(7228), pages 475-479, January.
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