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Top-down feedback controls spatial summation and response amplitude in primate visual cortex

Author

Listed:
  • Lauri Nurminen

    (University of Utah)

  • Sam Merlin

    (University of Utah
    Western Sydney University)

  • Maryam Bijanzadeh

    (University of Utah
    UCSF)

  • Frederick Federer

    (University of Utah)

  • Alessandra Angelucci

    (University of Utah)

Abstract

Sensory information travels along feedforward connections through a hierarchy of cortical areas, which, in turn, send feedback connections to lower-order areas. Feedback has been implicated in attention, expectation, and sensory context, but the mechanisms underlying these diverse feedback functions are unknown. Using specific optogenetic inactivation of feedback connections from the secondary visual area (V2), we show how feedback affects neural responses in the primate primary visual cortex (V1). Reducing feedback activity increases V1 cells’ receptive field (RF) size, decreases their responses to stimuli confined to the RF, and increases their responses to stimuli extending into the proximal surround, therefore reducing surround suppression. Moreover, stronger reduction of V2 feedback activity leads to progressive increase in RF size and decrease in response amplitude, an effect predicted by a recurrent network model. Our results indicate that feedback modulates RF size, surround suppression and response amplitude, similar to the modulatory effects of visual spatial attention.

Suggested Citation

  • Lauri Nurminen & Sam Merlin & Maryam Bijanzadeh & Frederick Federer & Alessandra Angelucci, 2018. "Top-down feedback controls spatial summation and response amplitude in primate visual cortex," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04500-5
    DOI: 10.1038/s41467-018-04500-5
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    Cited by:

    1. Alireza Saeedi & Kun Wang & Ghazaleh Nikpourian & Andreas Bartels & Nikos K. Logothetis & Nelson K. Totah & Masataka Watanabe, 2024. "Brightness illusions drive a neuronal response in the primary visual cortex under top-down modulation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Simon Weiler & Vahid Rahmati & Marcel Isstas & Johann Wutke & Andreas Walter Stark & Christian Franke & Jürgen Graf & Christian Geis & Otto W. Witte & Mark Hübener & Jürgen Bolz & Troy W. Margrie & Kn, 2024. "A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    3. Alan Consorti & Gabriele Sansevero & Irene Marco & Silvia Floridia & Elena Novelli & Nicoletta Berardi & Alessandro Sale, 2024. "An essential role for the latero-medial secondary visual cortex in the acquisition and retention of visual perceptual learning in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Xindong Song & Yueqi Guo & Hongbo Li & Chenggang Chen & Jong Hoon Lee & Yang Zhang & Zachary Schmidt & Xiaoqin Wang, 2022. "Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    5. Christina Mo & Claire McKinnon & S. Murray Sherman, 2024. "A transthalamic pathway crucial for perception," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Shan Shen & Xiaolong Jiang & Federico Scala & Jiakun Fu & Paul Fahey & Dmitry Kobak & Zhenghuan Tan & Na Zhou & Jacob Reimer & Fabian Sinz & Andreas S. Tolias, 2022. "Distinct organization of two cortico-cortical feedback pathways," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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