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Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity

Author

Listed:
  • Yevgeniy B. Sirotin

    (Department of Neuroscience,)

  • Aniruddha Das

    (Department of Neuroscience,
    Department of Psychiatry,
    W. M. Keck Center on Brain Plasticity and Cognition,
    Mahoney Center for Brain and Behavior,)

Abstract

The brain thinks ahead Functional magnetic resonance imaging (fMRI) of brain activity relies on the assumption that increases in local blood flow in the brain are directly correlated with the neuronal activity in that brain region. Using simultaneous direct recording and fMRI in monkeys, Yevgeniy Sirotin and Aniruddha Das demonstrate that this is not the whole story; part of the fMRI signal is unrelated to actual brain activity. As well as the brain activity component, there is increased blood flow in less active regions of the brain in anticipation of their employment in the near future. These findings challenge to the current interpretation of functional brain imaging signals, and also point to a novel anticipatory mechanism in the brain.

Suggested Citation

  • Yevgeniy B. Sirotin & Aniruddha Das, 2009. "Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity," Nature, Nature, vol. 457(7228), pages 475-479, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07664
    DOI: 10.1038/nature07664
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    Cited by:

    1. Zvi N. Roth & Elisha P. Merriam, 2023. "Representations in human primary visual cortex drift over time," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Xindong Song & Yueqi Guo & Hongbo Li & Chenggang Chen & Jong Hoon Lee & Yang Zhang & Zachary Schmidt & Xiaoqin Wang, 2022. "Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Hannah C. Bennett & Qingguang Zhang & Yuan-ting Wu & Steffy B. Manjila & Uree Chon & Donghui Shin & Daniel J. Vanselow & Hyun-Jae Pi & Patrick J. Drew & Yongsoo Kim, 2024. "Aging drives cerebrovascular network remodeling and functional changes in the mouse brain," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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