IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v457y2009i7228d10.1038_nature07664.html
   My bibliography  Save this article

Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity

Author

Listed:
  • Yevgeniy B. Sirotin

    (Department of Neuroscience,)

  • Aniruddha Das

    (Department of Neuroscience,
    Department of Psychiatry,
    W. M. Keck Center on Brain Plasticity and Cognition,
    Mahoney Center for Brain and Behavior,)

Abstract

The brain thinks ahead Functional magnetic resonance imaging (fMRI) of brain activity relies on the assumption that increases in local blood flow in the brain are directly correlated with the neuronal activity in that brain region. Using simultaneous direct recording and fMRI in monkeys, Yevgeniy Sirotin and Aniruddha Das demonstrate that this is not the whole story; part of the fMRI signal is unrelated to actual brain activity. As well as the brain activity component, there is increased blood flow in less active regions of the brain in anticipation of their employment in the near future. These findings challenge to the current interpretation of functional brain imaging signals, and also point to a novel anticipatory mechanism in the brain.

Suggested Citation

  • Yevgeniy B. Sirotin & Aniruddha Das, 2009. "Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity," Nature, Nature, vol. 457(7228), pages 475-479, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07664
    DOI: 10.1038/nature07664
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07664
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07664?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zvi N. Roth & Elisha P. Merriam, 2023. "Representations in human primary visual cortex drift over time," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Hannah C. Bennett & Qingguang Zhang & Yuan-ting Wu & Steffy B. Manjila & Uree Chon & Donghui Shin & Daniel J. Vanselow & Hyun-Jae Pi & Patrick J. Drew & Yongsoo Kim, 2024. "Aging drives cerebrovascular network remodeling and functional changes in the mouse brain," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Xindong Song & Yueqi Guo & Hongbo Li & Chenggang Chen & Jong Hoon Lee & Yang Zhang & Zachary Schmidt & Xiaoqin Wang, 2022. "Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07664. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.