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Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice

Author

Listed:
  • Mengci Li

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Shouli Wang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Yitao Li

    (Hong Kong Baptist University)

  • Mingliang Zhao

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Junliang Kuang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Dandan Liang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Jieyi Wang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Meilin Wei

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Cynthia Rajani

    (University of Hawaii Cancer Center)

  • Xinran Ma

    (East China Normal University)

  • Yajun Tang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Zhenxing Ren

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Tianlu Chen

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Aihua Zhao

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Cheng Hu

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute)

  • Chengxing Shen

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Weiping Jia

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute)

  • Ping Liu

    (Shanghai Jiao Tong University)

  • Xiaojiao Zheng

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Wei Jia

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
    Hong Kong Baptist University)

Abstract

Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-fat diet (HFD) both remodeled the gut microbiota with similar microbial composition, Parabacteroides distasonis was most significantly decreased after CR or HFD. CR altered microbiota and reprogramed metabolism, resulting in a distinct serum bile acid profile characterized by depleting the proportion of non-12α-hydroxylated bile acids, ursodeoxycholic acid and lithocholic acid. Downregulation of UCP1 expression in brown adipose tissue and decreased serum GLP-1 were observed in the weight-rebound mice. Moreover, treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain via increased thermogenesis. Our results highlighted the gut microbiota-bile acid crosstalk in rebound weight gain and Parabacteroides distasonis as a potential probiotic to prevent rapid post-CR weight gain.

Suggested Citation

  • Mengci Li & Shouli Wang & Yitao Li & Mingliang Zhao & Junliang Kuang & Dandan Liang & Jieyi Wang & Meilin Wei & Cynthia Rajani & Xinran Ma & Yajun Tang & Zhenxing Ren & Tianlu Chen & Aihua Zhao & Chen, 2022. "Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29589-7
    DOI: 10.1038/s41467-022-29589-7
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