IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0119362.html
   My bibliography  Save this article

Alcohol Induced Alterations to the Human Fecal VOC Metabolome

Author

Listed:
  • Robin D Couch
  • Allyson Dailey
  • Fatima Zaidi
  • Karl Navarro
  • Christopher B Forsyth
  • Ece Mutlu
  • Phillip A Engen
  • Ali Keshavarzian

Abstract

Studies have shown that excessive alcohol consumption impacts the intestinal microbiota composition, causing disruption of homeostasis (dysbiosis). However, this observed change is not indicative of the dysbiotic intestinal microbiota function that could result in the production of injurious and toxic products. Thus, knowledge of the effects of alcohol on the intestinal microbiota function and their metabolites is warranted, in order to better understand the role of the intestinal microbiota in alcohol associated organ failure. Here, we report the results of a differential metabolomic analysis comparing volatile organic compounds (VOC) detected in the stool of alcoholics and non-alcoholic healthy controls. We performed the analysis with fecal samples collected after passage as well as with samples collected directly from the sigmoid lumen. Regardless of the approach to fecal collection, we found a stool VOC metabolomic signature in alcoholics that is different from healthy controls. The most notable metabolite alterations in the alcoholic samples include: (1) an elevation in the oxidative stress biomarker tetradecane; (2) a decrease in five fatty alcohols with anti-oxidant property; (3) a decrease in the short chain fatty acids propionate and isobutyrate, important in maintaining intestinal epithelial cell health and barrier integrity; (4) a decrease in alcohol consumption natural suppressant caryophyllene; (5) a decrease in natural product and hepatic steatosis attenuator camphene; and (6) decreased dimethyl disulfide and dimethyl trisulfide, microbial products of decomposition. Our results showed that intestinal microbiota function is altered in alcoholics which might promote alcohol associated pathologies.

Suggested Citation

  • Robin D Couch & Allyson Dailey & Fatima Zaidi & Karl Navarro & Christopher B Forsyth & Ece Mutlu & Phillip A Engen & Ali Keshavarzian, 2015. "Alcohol Induced Alterations to the Human Fecal VOC Metabolome," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-24, March.
    • Handle: RePEc:plo:pone00:0119362
    DOI: 10.1371/journal.pone.0119362
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119362
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0119362&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0119362?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Lawrence A. David & Corinne F. Maurice & Rachel N. Carmody & David B. Gootenberg & Julie E. Button & Benjamin E. Wolfe & Alisha V. Ling & A. Sloan Devlin & Yug Varma & Michael A. Fischbach & Sudha B. , 2014. "Diet rapidly and reproducibly alters the human gut microbiome," Nature, Nature, vol. 505(7484), pages 559-563, January.
    2. Robin D Couch & Karl Navarro & Masoumeh Sikaroodi & Pat Gillevet & Christopher B Forsyth & Ece Mutlu & Phillip A Engen & Ali Keshavarzian, 2013. "The Approach to Sample Acquisition and Its Impact on the Derived Human Fecal Microbiome and VOC Metabolome," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gregory E Miller & Phillip A Engen & Patrick M Gillevet & Maliha Shaikh & Masoumeh Sikaroodi & Christopher B Forsyth & Ece Mutlu & Ali Keshavarzian, 2016. "Lower Neighborhood Socioeconomic Status Associated with Reduced Diversity of the Colonic Microbiota in Healthy Adults," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-17, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Iris Chen & Yogeshwar D Kelkar & Yu Gu & Jie Zhou & Xing Qiu & Hulin Wu, 2017. "High-dimensional linear state space models for dynamic microbial interaction networks," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-20, November.
    2. Joanna F Dipnall & Julie A Pasco & Michael Berk & Lana J Williams & Seetal Dodd & Felice N Jacka & Denny Meyer, 2016. "Into the Bowels of Depression: Unravelling Medical Symptoms Associated with Depression by Applying Machine-Learning Techniques to a Community Based Population Sample," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-19, December.
    3. Huimin Ye & Sabrina Borusak & Claudia Eberl & Julia Krasenbrink & Anna S. Weiss & Song-Can Chen & Buck T. Hanson & Bela Hausmann & Craig W. Herbold & Manuel Pristner & Benjamin Zwirzitz & Benedikt War, 2023. "Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Alice Risely & Kerstin Wilhelm & Tim Clutton-Brock & Marta B. Manser & Simone Sommer, 2021. "Diurnal oscillations in gut bacterial load and composition eclipse seasonal and lifetime dynamics in wild meerkats," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    5. Hania M. Taha & Alexander N. Slade & Betty Schwartz & Anna E. Arthur, 2022. "A Case–Control Study Examining the Association of Fiber, Fruit, and Vegetable Intake and the Risk of Colorectal Cancer in a Palestinian Population," IJERPH, MDPI, vol. 19(12), pages 1-11, June.
    6. Sarah L Hagerty & Kent E Hutchison & Christopher A Lowry & Angela D Bryan, 2020. "An empirically derived method for measuring human gut microbiome alpha diversity: Demonstrated utility in predicting health-related outcomes among a human clinical sample," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-21, March.
    7. Lharbi Dridi & Fernando Altamura & Emmanuel Gonzalez & Olivia Lui & Ryszard Kubinski & Reilly Pidgeon & Adrian Montagut & Jasmine Chong & Jianguo Xia & Corinne F. Maurice & Bastien Castagner, 2023. "Identifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    8. Muntsa Rocafort & David B. Gootenberg & Jesús M. Luévano & Jeffrey M. Paer & Matthew R. Hayward & Juliet T. Bramante & Musie S. Ghebremichael & Jiawu Xu & Zoe H. Rogers & Alexander R. Munoz & Samson O, 2024. "HIV-associated gut microbial alterations are dependent on host and geographic context," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    9. Lidy M Pelsser & Klaas Frankena & Jan Toorman & Rob Rodrigues Pereira, 2017. "Diet and ADHD, Reviewing the Evidence: A Systematic Review of Meta-Analyses of Double-Blind Placebo-Controlled Trials Evaluating the Efficacy of Diet Interventions on the Behavior of Children with ADH," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-25, January.
    10. Lena Takayasu & Wataru Suda & Eiichiro Watanabe & Shinji Fukuda & Kageyasu Takanashi & Hiroshi Ohno & Misako Takayasu & Hideki Takayasu & Masahira Hattori, 2017. "A 3-dimensional mathematical model of microbial proliferation that generates the characteristic cumulative relative abundance distributions in gut microbiomes," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-20, August.
    11. Giuliano Bonanomi & Mohamed Idbella & Ahmed M. Abd-ElGawad, 2021. "Microbiota Management for Effective Disease Suppression: A Systematic Comparison between Soil and Mammals Gut," Sustainability, MDPI, vol. 13(14), pages 1-16, July.
    12. Michał Szklarz & Katarzyna Gontarz-Nowak & Wojciech Matuszewski & Elżbieta Bandurska-Stankiewicz, 2022. "Can Iron Play a Crucial Role in Maintaining Cardiovascular Health in the 21st Century?," IJERPH, MDPI, vol. 19(19), pages 1-32, September.
    13. Tong Wang & Hannah D. Holscher & Sergei Maslov & Frank B. Hu & Scott T. Weiss & Yang-Yu Liu, 2025. "Predicting metabolite response to dietary intervention using deep learning," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    14. Hagai Yanai & Bongsoo Park & Hyunwook Koh & Hyo Jung Jang & Kelli L. Vaughan & Mayuri Tanaka-Yano & Miguel Aon & Madison Blanton & Ilhem Messaoudi & Alberto Diaz-Ruiz & Julie A. Mattison & Isabel Beer, 2024. "Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    15. Patricia Grace-Farfaglia & Heather Frazier & Maura Daly Iversen, 2022. "Essential Factors for a Healthy Microbiome: A Scoping Review," IJERPH, MDPI, vol. 19(14), pages 1-21, July.
    16. Aarthi Ravikrishnan & Indrik Wijaya & Eileen Png & Kern Rei Chng & Eliza Xin Pei Ho & Amanda Hui Qi Ng & Ahmad Nazri Mohamed Naim & Jean-Sebastien Gounot & Shou Ping Guan & Jasinda Lee Hanqing & Lihua, 2024. "Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    17. John R Lee & Thangamani Muthukumar & Darshana Dadhania & Ying Taur & Robert R Jenq & Nora C Toussaint & Lilan Ling & Eric Pamer & Manikkam Suthanthiran, 2015. "Gut Microbiota and Tacrolimus Dosing in Kidney Transplantation," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-17, March.
    18. Zahraa Al Bander & Marloes Dekker Nitert & Aya Mousa & Negar Naderpoor, 2020. "The Gut Microbiota and Inflammation: An Overview," IJERPH, MDPI, vol. 17(20), pages 1-21, October.
    19. Palmiro Poltronieri, 2018. "Challenges in the Healthcare Systems and Formative Needs of Family Doctors," Challenges, MDPI, vol. 9(2), pages 1-3, August.
    20. Andrea Piccioni & Tommaso de Cunzo & Federico Valletta & Marcello Covino & Emanuele Rinninella & Pauline Raoul & Christian Zanza & Maria Cristina Mele & Francesco Franceschi, 2021. "Gut Microbiota and Environment in Coronary Artery Disease," IJERPH, MDPI, vol. 18(8), pages 1-15, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0119362. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.