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SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress

Author

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  • Abdallah Zayed

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

  • Camille Baranowski

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

  • Anne-Claire Compagnion

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

  • Cécile Vernochet

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

  • Samah Karaki

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

  • Romain Durand-de Cuttoli

    (Sorbonne Université, Neurophysiology and Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC)

  • Estefani Saint-Jour

    (Sorbonne Université, Neuronal Signaling and Gene Regulation, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC)

  • Soumee Bhattacharya

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

  • Fabio Marti

    (Sorbonne Université, Neurophysiology and Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC
    PSL Research University)

  • Peter Vanhoutte

    (Sorbonne Université, Neuronal Signaling and Gene Regulation, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC)

  • Moshe Yaniv

    (Pasteur Institute)

  • Philippe Faure

    (Sorbonne Université, Neurophysiology and Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC
    PSL Research University)

  • Jacques Barik

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM
    Université Côte d’Azur
    Physiopathology of Neuronal Circuits and Behavior, IPMC)

  • Laurence Amar

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

  • François Tronche

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

  • Sébastien Parnaudeau

    (Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM)

Abstract

Enduring behavioral changes upon stress exposure involve changes in gene expression sustained by epigenetic modifications in brain circuits, including the mesocorticolimbic pathway. Brahma (BRM) and Brahma Related Gene 1 (BRG1) are ATPase subunits of the SWI/SNF complexes involved in chromatin remodeling, a process essential to enduring plastic changes in gene expression. Here, we show that in mice, social defeat induces changes in BRG1 nuclear distribution. The inactivation of the Brg1/Smarca4 gene within dopamine-innervated regions or the constitutive inactivation of the Brm/Smarca2 gene leads to resilience to repeated social defeat and decreases the behavioral responses to cocaine without impacting midbrain dopamine neurons activity. Within striatal medium spiny neurons, Brg1 gene inactivation reduces the expression of stress- and cocaine-induced immediate early genes, increases levels of heterochromatin and at a global scale decreases chromatin accessibility. Altogether these data demonstrate the pivotal function of SWI/SNF complexes in behavioral and transcriptional adaptations to salient environmental challenges.

Suggested Citation

  • Abdallah Zayed & Camille Baranowski & Anne-Claire Compagnion & Cécile Vernochet & Samah Karaki & Romain Durand-de Cuttoli & Estefani Saint-Jour & Soumee Bhattacharya & Fabio Marti & Peter Vanhoutte & , 2022. "SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29380-8
    DOI: 10.1038/s41467-022-29380-8
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