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Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Author

Listed:
  • Dipesh Chaudhury

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Jessica J. Walsh

    (Friedman Brain Institute, Mount Sinai School of Medicine
    Friedman Brain Institute, Mount Sinai School of Medicine)

  • Allyson K. Friedman

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Barbara Juarez

    (Friedman Brain Institute, Mount Sinai School of Medicine
    Friedman Brain Institute, Mount Sinai School of Medicine)

  • Stacy M. Ku

    (Friedman Brain Institute, Mount Sinai School of Medicine
    Friedman Brain Institute, Mount Sinai School of Medicine)

  • Ja Wook Koo

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Deveroux Ferguson

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Hsing-Chen Tsai

    (Stanford University)

  • Lisa Pomeranz

    (Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University)

  • Daniel J. Christoffel

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Alexander R. Nectow

    (Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University)

  • Mats Ekstrand

    (Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University)

  • Ana Domingos

    (Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University)

  • Michelle S. Mazei-Robison

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Ezekiell Mouzon

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Mary Kay Lobo

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Rachael L. Neve

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Jeffrey M. Friedman

    (Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University)

  • Scott J. Russo

    (Friedman Brain Institute, Mount Sinai School of Medicine)

  • Karl Deisseroth

    (Stanford University)

  • Eric J. Nestler

    (Friedman Brain Institute, Mount Sinai School of Medicine
    Friedman Brain Institute, Mount Sinai School of Medicine)

  • Ming-Hu Han

    (Friedman Brain Institute, Mount Sinai School of Medicine
    Friedman Brain Institute, Mount Sinai School of Medicine)

Abstract

Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat paradigm and in previously resilient mice that have been subjected to repeated social-defeat stress, and this effect is projection-pathway specific.

Suggested Citation

  • Dipesh Chaudhury & Jessica J. Walsh & Allyson K. Friedman & Barbara Juarez & Stacy M. Ku & Ja Wook Koo & Deveroux Ferguson & Hsing-Chen Tsai & Lisa Pomeranz & Daniel J. Christoffel & Alexander R. Nect, 2013. "Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons," Nature, Nature, vol. 493(7433), pages 532-536, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7433:d:10.1038_nature11713
    DOI: 10.1038/nature11713
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    Citations

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    Cited by:

    1. Jing Huang & Weijun Huang & Junzhe Yi & Yiwen Deng & Ruijie Li & Jieying Chen & Jiahao Shi & Yuan Qiu & Tao Wang & Xiaoyong Chen & Xiaoran Zhang & Andy Peng Xiang, 2023. "Mesenchymal stromal cells alleviate depressive and anxiety-like behaviors via a lung vagal-to-brain axis in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Carole Morel & Sarah E. Montgomery & Long Li & Romain Durand-de Cuttoli & Emily M. Teichman & Barbara Juarez & Nikos Tzavaras & Stacy M. Ku & Meghan E. Flanigan & Min Cai & Jessica J. Walsh & Scott J., 2022. "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Robert N. Fetcho & Baila S. Hall & David J. Estrin & Alexander P. Walsh & Peter J. Schuette & Jesse Kaminsky & Ashna Singh & Jacob Roshgodal & Charlotte C. Bavley & Viraj Nadkarni & Susan Antigua & Th, 2023. "Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Grace Png & Andrei Barysenka & Linda Repetto & Pau Navarro & Xia Shen & Maik Pietzner & Eleanor Wheeler & Nicholas J. Wareham & Claudia Langenberg & Emmanouil Tsafantakis & Maria Karaleftheri & George, 2021. "Mapping the serum proteome to neurological diseases using whole genome sequencing," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    5. Yi Han & Lin Ai & Lingzhen Song & Yu Zhou & Dandan Chen & Sha Sha & Ran Ji & Qize Li & Qingyang Bu & Xiangyu Pan & Xiaojing Zhai & Mengqiao Cui & Jiawen Duan & Junxia Yang & Dipesh Chaudhury & Ankang , 2024. "Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Soo Hyun Yang & Esther Yang & Jaekwang Lee & Jin Yong Kim & Hyeijung Yoo & Hyung Sun Park & Jin Taek Jung & Dongmin Lee & Sungkun Chun & Yong Sang Jo & Gyeong Hee Pyeon & Jae-Yong Park & Hyun Woo Lee , 2023. "Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    7. Abdallah Zayed & Camille Baranowski & Anne-Claire Compagnion & Cécile Vernochet & Samah Karaki & Romain Durand-de Cuttoli & Estefani Saint-Jour & Soumee Bhattacharya & Fabio Marti & Peter Vanhoutte & , 2022. "SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    8. Can Tao & Guang-Wei Zhang & Wen-Jian Sun & Junxiang J. Huang & Li I. Zhang & Huizhong Whit Tao, 2024. "Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    9. Shan Yao & Min-Dong Xu & Ying Wang & Shen-Ting Zhao & Jin Wang & Gui-Fu Chen & Wen-Bing Chen & Jian Liu & Guo-Bin Huang & Wen-Juan Sun & Yan-Yan Zhang & Huan-Li Hou & Lei Li & Xiang-Dong Sun, 2023. "Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    10. Jeroen P. H. Verharen & Johannes W. Jong & Yichen Zhu & Stephan Lammel, 2023. "A computational analysis of mouse behavior in the sucrose preference test," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    11. Weiping Dai & Mengqian Yang & Pei Xia & Chuan Xiao & Shuying Huang & Zhan Zhang & Xin Cheng & Wenchang Li & Jian Jin & Jingyun Zhang & Binghuo Wu & Yingying Zhang & Pei-hui Wu & Yangyang Lin & Wen Wu , 2022. "A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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