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BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens

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  • André O. White

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California)

  • Enikö A. Kramár

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California)

  • Alberto J. López

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California)

  • Janine L. Kwapis

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California
    Institute for Memory Impairments and Neurological Disorders, University of California)

  • John Doan

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California)

  • David Saldana

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California)

  • M. Felicia Davatolhagh

    (Perelman School of Medicine at the University of Pennsylvania)

  • Yasaman Alaghband

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California)

  • Mathew Blurton-Jones

    (301 Qureshey Research Lab, University of California
    Institute for Memory Impairments and Neurological Disorders, University of California
    Sue and Bill Gross Stem Cell Research Center, University of California)

  • Dina P. Matheos

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California)

  • Marcelo A. Wood

    (301 Qureshey Research Lab, University of California
    Center for the Neurobiology of Learning and Memory
    Irvine Center for Addiction Neuroscience (ICAN), University of California
    Institute for Memory Impairments and Neurological Disorders, University of California)

Abstract

Recent evidence implicates epigenetic mechanisms in drug-associated memory processes. However, a possible role for one major epigenetic mechanism, nucleosome remodelling, in drug-associated memories remains largely unexplored. Here we examine mice with genetic manipulations targeting a neuron-specific nucleosome remodelling complex subunit, BAF53b. These mice display deficits in cocaine-associated memory that are more severe in BAF53b transgenic mice compared with BAF53b heterozygous mice. Similar to the memory deficits, theta-induced long-term potentiation (theta-LTP) in the nucleus accumbens (NAc) is significantly impaired in slices taken from BAF53b transgenic mice but not heterozygous mice. Further experiments indicate that theta-LTP in the NAc is dependent on TrkB receptor activation, and that BDNF rescues theta-LTP and cocaine-associated memory deficits in BAF53b transgenic mice. Together, these results suggest a role for BAF53b in NAc neuronal function required for cocaine-associated memories, and also that BDNF/TrkB activation in the NAc may overcome memory and plasticity deficits linked to BAF53b mutations.

Suggested Citation

  • André O. White & Enikö A. Kramár & Alberto J. López & Janine L. Kwapis & John Doan & David Saldana & M. Felicia Davatolhagh & Yasaman Alaghband & Mathew Blurton-Jones & Dina P. Matheos & Marcelo A. Wo, 2016. "BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11725
    DOI: 10.1038/ncomms11725
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    Cited by:

    1. Abdallah Zayed & Camille Baranowski & Anne-Claire Compagnion & Cécile Vernochet & Samah Karaki & Romain Durand-de Cuttoli & Estefani Saint-Jour & Soumee Bhattacharya & Fabio Marti & Peter Vanhoutte & , 2022. "SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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