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Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations

Author

Listed:
  • Åshild J. Vågene

    (Max Planck Institute for the Science of Human History
    University of Tübingen
    University of Copenhagen)

  • Tanvi P. Honap

    (Arizona State University
    University of Oklahoma
    University of Oklahoma)

  • Kelly M. Harkins

    (Arizona State University)

  • Michael S. Rosenberg

    (Arizona State University
    Virginia Commonwealth University)

  • Karen Giffin

    (Max Planck Institute for the Science of Human History
    Max Planck Institute for Evolutionary Anthropology)

  • Felipe Cárdenas-Arroyo

    (Colombian Institute of Anthropology and History (ICANH))

  • Laura Paloma Leguizamón

    (Colombian Institute of Anthropology and History (ICANH))

  • Judith Arnett

    (Arizona State University
    University of the Andes, School of Medicine)

  • Jane E. Buikstra

    (Arizona State University)

  • Alexander Herbig

    (Max Planck Institute for the Science of Human History
    University of Tübingen
    Max Planck Institute for Evolutionary Anthropology)

  • Johannes Krause

    (Max Planck Institute for the Science of Human History
    University of Tübingen
    Max Planck Institute for Evolutionary Anthropology)

  • Anne C. Stone

    (Arizona State University
    Arizona State University
    Arizona State University)

  • Kirsten I. Bos

    (Max Planck Institute for the Science of Human History
    University of Tübingen
    Max Planck Institute for Evolutionary Anthropology)

Abstract

Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the coastal areas of Peru prior to European colonization. Skeletal evidence indicates the presence of TB in several pre-colonial South and North American populations with minimal access to marine resources— a scenario incompatible with TB transmission directly from infected pinnipeds or their tissues. In this study, we investigate the causative agent of TB in ten pre-colonial, non-coastal individuals from South America. We reconstruct M. pinnipedii genomes (10- to 15-fold mean coverage) from three contemporaneous individuals from inland Peru and Colombia, demonstrating the widespread dissemination of M. pinnipedii beyond the coast, either through human-to-human and/or animal-mediated routes. Overall, our study suggests that TB transmission in the pre-colonial era Americas involved a more complex transmission pathway than simple pinniped-to-human transfer.

Suggested Citation

  • Åshild J. Vågene & Tanvi P. Honap & Kelly M. Harkins & Michael S. Rosenberg & Karen Giffin & Felipe Cárdenas-Arroyo & Laura Paloma Leguizamón & Judith Arnett & Jane E. Buikstra & Alexander Herbig & Jo, 2022. "Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28562-8
    DOI: 10.1038/s41467-022-28562-8
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    References listed on IDEAS

    as
    1. Gemma L. Kay & Martin J. Sergeant & Zhemin Zhou & Jacqueline Z.-M. Chan & Andrew Millard & Joshua Quick & Ildikó Szikossy & Ildikó Pap & Mark Spigelman & Nicholas J. Loman & Mark Achtman & Helen D. Do, 2015. "Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe," Nature Communications, Nature, vol. 6(1), pages 1-9, November.
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