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Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere

Author

Listed:
  • Yelin Han

    (Chinese Academy of Medical Sciences & Peking Union Medical College
    Chinese Academy of Medical Sciences & Peking Union Medical College
    Ministry of Education
    Chinese Academy of Medical Sciences)

  • Panpan Xu

    (Chinese Academy of Medical Sciences & Peking Union Medical College
    Chinese Academy of Medical Sciences & Peking Union Medical College
    Ministry of Education
    Chinese Academy of Medical Sciences)

  • Yuyang Wang

    (Chinese Academy of Medical Sciences & Peking Union Medical College
    Chinese Academy of Medical Sciences & Peking Union Medical College
    Ministry of Education
    Chinese Academy of Medical Sciences)

  • Wenliang Zhao

    (Chinese Academy of Medical Sciences & Peking Union Medical College
    Chinese Academy of Medical Sciences & Peking Union Medical College
    Ministry of Education
    Chinese Academy of Medical Sciences)

  • Junpeng Zhang

    (Shenyang Agricultural University)

  • Shuyi Zhang

    (Shenyang Agricultural University)

  • Jianwei Wang

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Qi Jin

    (Chinese Academy of Medical Sciences & Peking Union Medical College
    Ministry of Education
    Chinese Academy of Medical Sciences)

  • Zhiqiang Wu

    (Chinese Academy of Medical Sciences & Peking Union Medical College
    Chinese Academy of Medical Sciences & Peking Union Medical College
    Ministry of Education
    Chinese Academy of Medical Sciences)

Abstract

Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve as natural hosts for several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Investigating the bat CoV community provides insights into the origin for highly pathogenic CoVs and highlights bat CoVs with potential spillover risks. This study probes the evolution, recombination, host range, geographical distribution, and cross-species transmission characteristics of bat CoVs across China and its associated CoVs in other regions. Through detailed research on 13,064 bat samples from 14 provinces of China, 1141 CoV strains are found across 10 subgenera and one unclassified Alpha-CoV, generating 399 complete genome sequences. Within bat CoVs, 11 new CoV species are identified and 425 recombination events are detected. Bats in southern China, particularly in Yunnan province, exhibit a pronounced diversity of CoVs. Limited sampling and low detection rates exist for CoVs in Myotacovirus, Nyctacovirus, Hibecovirus, Nobecovirus in China. The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV, indicating the complexity of cross-species transmission dynamics. Through the comprehensive analysis, this study enriches the understanding of bat CoVs and offers a valuable resource for future research.

Suggested Citation

  • Yelin Han & Panpan Xu & Yuyang Wang & Wenliang Zhao & Junpeng Zhang & Shuyi Zhang & Jianwei Wang & Qi Jin & Zhiqiang Wu, 2023. "Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41264-z
    DOI: 10.1038/s41467-023-41264-z
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    as
    1. Daniel H Huson & Sina Beier & Isabell Flade & Anna Górska & Mohamed El-Hadidi & Suparna Mitra & Hans-Joachim Ruscheweyh & Rewati Tappu, 2016. "MEGAN Community Edition - Interactive Exploration and Analysis of Large-Scale Microbiome Sequencing Data," PLOS Computational Biology, Public Library of Science, vol. 12(6), pages 1-12, June.
    2. Peng Zhou & Xing-Lou Yang & Xian-Guang Wang & Ben Hu & Lei Zhang & Wei Zhang & Hao-Rui Si & Yan Zhu & Bei Li & Chao-Lin Huang & Hui-Dong Chen & Jing Chen & Yun Luo & Hua Guo & Ren-Di Jiang & Mei-Qin L, 2020. "Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin," Nature, Nature, vol. 588(7836), pages 6-6, December.
    3. Peng Zhou & Xing-Lou Yang & Xian-Guang Wang & Ben Hu & Lei Zhang & Wei Zhang & Hao-Rui Si & Yan Zhu & Bei Li & Chao-Lin Huang & Hui-Dong Chen & Jing Chen & Yun Luo & Hua Guo & Ren-Di Jiang & Mei-Qin L, 2020. "A pneumonia outbreak associated with a new coronavirus of probable bat origin," Nature, Nature, vol. 579(7798), pages 270-273, March.
    4. Xing-Yi Ge & Jia-Lu Li & Xing-Lou Yang & Aleksei A. Chmura & Guangjian Zhu & Jonathan H. Epstein & Jonna K. Mazet & Ben Hu & Wei Zhang & Cheng Peng & Yu-Ji Zhang & Chu-Ming Luo & Bing Tan & Ning Wang , 2013. "Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor," Nature, Nature, vol. 503(7477), pages 535-538, November.
    5. Sarah Temmam & Khamsing Vongphayloth & Eduard Baquero & Sandie Munier & Massimiliano Bonomi & Béatrice Regnault & Bounsavane Douangboubpha & Yasaman Karami & Delphine Chrétien & Daosavanh Sanamxay & V, 2022. "Author Correction: Bat coronaviruses related to SARS-CoV-2 and infectious for human cells," Nature, Nature, vol. 607(7920), pages 19-19, July.
    6. Peng Zhou & Hang Fan & Tian Lan & Xing-Lou Yang & Wei-Feng Shi & Wei Zhang & Yan Zhu & Ya-Wei Zhang & Qing-Mei Xie & Shailendra Mani & Xiao-Shuang Zheng & Bei Li & Jin-Man Li & Hua Guo & Guang-Qian Pe, 2018. "Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin," Nature, Nature, vol. 556(7700), pages 255-258, April.
    7. Jinfang Yu & Shuyuan Qiao & Runyu Guo & Xinquan Wang, 2020. "Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    8. Alice Latinne & Ben Hu & Kevin J. Olival & Guangjian Zhu & Libiao Zhang & Hongying Li & Aleksei A. Chmura & Hume E. Field & Carlos Zambrana-Torrelio & Jonathan H. Epstein & Bei Li & Wei Zhang & Lin-Fa, 2020. "Origin and cross-species transmission of bat coronaviruses in China," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    9. Sarah Temmam & Khamsing Vongphayloth & Eduard Baquero & Sandie Munier & Massimiliano Bonomi & Béatrice Regnault & Bounsavane Douangboubpha & Yasaman Karami & Delphine Chrétien & Daosavanh Sanamxay & V, 2022. "Bat coronaviruses related to SARS-CoV-2 and infectious for human cells," Nature, Nature, vol. 604(7905), pages 330-336, April.
    10. Smriti Mallapaty, 2021. "Closest known relatives of virus behind COVID-19 found in Laos," Nature, Nature, vol. 597(7878), pages 603-603, September.
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