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Direct-laser writing for subnanometer focusing and single-molecule imaging

Author

Listed:
  • Simao Coelho

    (University of New South Wales
    University of New South Wales
    Memorial Sloan Kettering Cancer Center
    Instituto Gulbenkian de Ciência)

  • Jongho Baek

    (University of New South Wales
    University of New South Wales
    KAIST)

  • James Walsh

    (University of New South Wales
    University of New South Wales)

  • J. Justin Gooding

    (University of New South Wales
    University of New South Wales)

  • Katharina Gaus

    (University of New South Wales
    University of New South Wales)

Abstract

Two-photon direct laser writing is an additive fabrication process that utilizes two-photon absorption of tightly focused femtosecond laser pulses to implement spatially controlled polymerization of a liquid-phase photoresist. Two-photon direct laser writing is capable of nanofabricating arbitrary three-dimensional structures with nanometer accuracy. Here, we explore direct laser writing for high-resolution optical microscopy by fabricating unique 3D optical fiducials for single-molecule tracking and 3D single-molecule localization microscopy. By having control over the position and three-dimensional architecture of the fiducials, we improve axial discrimination and demonstrate isotropic subnanometer 3D focusing (

Suggested Citation

  • Simao Coelho & Jongho Baek & James Walsh & J. Justin Gooding & Katharina Gaus, 2022. "Direct-laser writing for subnanometer focusing and single-molecule imaging," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28219-6
    DOI: 10.1038/s41467-022-28219-6
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    References listed on IDEAS

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