IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-021-27932-y.html
   My bibliography  Save this article

A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging

Author

Listed:
  • Han Ren

    (CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST))

  • Xiang-Zhong Zeng

    (CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST)
    University of Chinese Academy of Sciences (UCAS)
    Peking University)

  • Xiao-Xiao Zhao

    (CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST))

  • Da-yong Hou

    (CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST)
    Department of Urology, The Fourth Hospital of Harbin Medical University, Heilongjiang Key Laboratory of Scientific Research in Urology
    Harbin Medical University)

  • Haodong Yao

    (Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Muhammad Yaseen

    (University of Peshawar)

  • Lina Zhao

    (Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Wan-hai Xu

    (Department of Urology, The Fourth Hospital of Harbin Medical University, Heilongjiang Key Laboratory of Scientific Research in Urology
    Harbin Medical University)

  • Hao Wang

    (CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST))

  • Li-Li Li

    (CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST))

Abstract

Real-time imaging of the tumour boundary is important during surgery to ensure that sufficient tumour tissue has been removed. However, the current fluorescence probes for bioimaging suffer from poor tumour specificity and narrow application of the imaging window used. Here, we report a bioactivated in vivo assembly (BIVA) nanotechnology, demonstrating a general optical probe with enhanced tumour accumulation and prolonged imaging window. The BIVA probe exhibits active targeting and assembly induced retention effect, which improves selectivity to tumours. The surface specific nanofiber assembly on the tumour surface increases the accumulation of probe at the boundary of the tumor. The blood circulation time of the BIVA probe is prolonged by 110 min compared to idocyanine green. The assembly induced metabolic stability broaden the difference between the tumor and background, obtaining a delayed imaging window between 8–96 h with better signal-to-background contrast (>9 folds). The fabricated BIVA probe permits precise imaging of small sized (

Suggested Citation

  • Han Ren & Xiang-Zhong Zeng & Xiao-Xiao Zhao & Da-yong Hou & Haodong Yao & Muhammad Yaseen & Lina Zhao & Wan-hai Xu & Hao Wang & Li-Li Li, 2022. "A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27932-y
    DOI: 10.1038/s41467-021-27932-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27932-y
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-021-27932-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Peiyuan Wang & Yong Fan & Lingfei Lu & Lu Liu & Lingling Fan & Mengyao Zhao & Yang Xie & Congjian Xu & Fan Zhang, 2018. "NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Weiqi Zhang & Yinghua Zeng & Qiuqun Xiao & Yuanyuan Wu & Jiale Liu & Haocheng Wang & Yuting Luo & Jie Zhan & Ning Liao & Yanbin Cai, 2024. "An in-situ peptide-antibody self-assembly to block CD47 and CD24 signaling enhances macrophage-mediated phagocytosis and anti-tumor immune responses," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Meijie Pan & Ruiyang Zhao & Chuanxun Fu & Mingmei Tang & Jiayi Zhou & Bin Ma & Jianxiong Liu & Ye Yang & Binlong Chen & Qiang Zhang & Yiguang Wang, 2024. "Tuning nanoparticle core composition drives orthogonal fluorescence amplification for enhanced tumour imaging," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Danni Zhong & Weiyu Chen & Zhiming Xia & Rong Hu & Yuchen Qi & Bo Zhou & Wanlin Li & Jian He & Zhiming Wang & Zujin Zhao & Dan Ding & Mei Tian & Ben Zhong Tang & Min Zhou, 2021. "Aggregation-induced emission luminogens for image-guided surgery in non-human primates," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Rui Tian & Xin Feng & Long Wei & Daoguo Dai & Ying Ma & Haifeng Pan & Shengxiang Ge & Lang Bai & Chaomin Ke & Yanlin Liu & Lixin Lang & Shoujun Zhu & Haitao Sun & Yanbao Yu & Xiaoyuan Chen, 2022. "A genetic engineering strategy for editing near-infrared-II fluorophores," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27932-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.