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NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer

Author

Listed:
  • Peiyuan Wang

    (Fudan University)

  • Yong Fan

    (Fudan University)

  • Lingfei Lu

    (Fudan University)

  • Lu Liu

    (Fudan University)

  • Lingling Fan

    (Fudan University
    Fudan University)

  • Mengyao Zhao

    (Fudan University)

  • Yang Xie

    (Second Military Medical University)

  • Congjian Xu

    (Fudan University
    Fudan University)

  • Fan Zhang

    (Fudan University)

Abstract

Local recurrence is a common cause of treatment failure for patients with solid tumors. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and, thereby improve prognosis. Here, we report in vivo assembly of the second near-infrared window (NIR-II) emitting downconversion nanoparticles (DCNPs) modified with DNA and targeting peptides to improve the image-guided surgery for metastatic ovarian cancer. The NIR-II imaging quality with DCNPs is superior to that of clinically approved ICG with good photostability and deep tissue penetration (8 mm). Stable tumor retention period experienced 6 h by in vivo assembly of nanoprobes can be used for precise tumor resection. Superior tumor-to-normal tissue ratio is successfully achieved to facilitate the abdominal ovarian metastases surgical delineation. Metastases with ≤1 mm can be completely excised under NIR-II bioimaging guidance. This novel technology provides a general new basis for the future design of nanomaterials for medical applications.

Suggested Citation

  • Peiyuan Wang & Yong Fan & Lingfei Lu & Lu Liu & Lingling Fan & Mengyao Zhao & Yang Xie & Congjian Xu & Fan Zhang, 2018. "NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05113-8
    DOI: 10.1038/s41467-018-05113-8
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    Cited by:

    1. Danni Zhong & Weiyu Chen & Zhiming Xia & Rong Hu & Yuchen Qi & Bo Zhou & Wanlin Li & Jian He & Zhiming Wang & Zujin Zhao & Dan Ding & Mei Tian & Ben Zhong Tang & Min Zhou, 2021. "Aggregation-induced emission luminogens for image-guided surgery in non-human primates," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Han Ren & Xiang-Zhong Zeng & Xiao-Xiao Zhao & Da-yong Hou & Haodong Yao & Muhammad Yaseen & Lina Zhao & Wan-hai Xu & Hao Wang & Li-Li Li, 2022. "A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Meijie Pan & Ruiyang Zhao & Chuanxun Fu & Mingmei Tang & Jiayi Zhou & Bin Ma & Jianxiong Liu & Ye Yang & Binlong Chen & Qiang Zhang & Yiguang Wang, 2024. "Tuning nanoparticle core composition drives orthogonal fluorescence amplification for enhanced tumour imaging," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Rui Tian & Xin Feng & Long Wei & Daoguo Dai & Ying Ma & Haifeng Pan & Shengxiang Ge & Lang Bai & Chaomin Ke & Yanlin Liu & Lixin Lang & Shoujun Zhu & Haitao Sun & Yanbao Yu & Xiaoyuan Chen, 2022. "A genetic engineering strategy for editing near-infrared-II fluorophores," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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