IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05113-8.html
   My bibliography  Save this article

NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer

Author

Listed:
  • Peiyuan Wang

    (Fudan University)

  • Yong Fan

    (Fudan University)

  • Lingfei Lu

    (Fudan University)

  • Lu Liu

    (Fudan University)

  • Lingling Fan

    (Fudan University
    Fudan University)

  • Mengyao Zhao

    (Fudan University)

  • Yang Xie

    (Second Military Medical University)

  • Congjian Xu

    (Fudan University
    Fudan University)

  • Fan Zhang

    (Fudan University)

Abstract

Local recurrence is a common cause of treatment failure for patients with solid tumors. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and, thereby improve prognosis. Here, we report in vivo assembly of the second near-infrared window (NIR-II) emitting downconversion nanoparticles (DCNPs) modified with DNA and targeting peptides to improve the image-guided surgery for metastatic ovarian cancer. The NIR-II imaging quality with DCNPs is superior to that of clinically approved ICG with good photostability and deep tissue penetration (8 mm). Stable tumor retention period experienced 6 h by in vivo assembly of nanoprobes can be used for precise tumor resection. Superior tumor-to-normal tissue ratio is successfully achieved to facilitate the abdominal ovarian metastases surgical delineation. Metastases with ≤1 mm can be completely excised under NIR-II bioimaging guidance. This novel technology provides a general new basis for the future design of nanomaterials for medical applications.

Suggested Citation

  • Peiyuan Wang & Yong Fan & Lingfei Lu & Lu Liu & Lingling Fan & Mengyao Zhao & Yang Xie & Congjian Xu & Fan Zhang, 2018. "NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05113-8
    DOI: 10.1038/s41467-018-05113-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05113-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05113-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Danni Zhong & Weiyu Chen & Zhiming Xia & Rong Hu & Yuchen Qi & Bo Zhou & Wanlin Li & Jian He & Zhiming Wang & Zujin Zhao & Dan Ding & Mei Tian & Ben Zhong Tang & Min Zhou, 2021. "Aggregation-induced emission luminogens for image-guided surgery in non-human primates," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Han Ren & Xiang-Zhong Zeng & Xiao-Xiao Zhao & Da-yong Hou & Haodong Yao & Muhammad Yaseen & Lina Zhao & Wan-hai Xu & Hao Wang & Li-Li Li, 2022. "A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Rui Tian & Xin Feng & Long Wei & Daoguo Dai & Ying Ma & Haifeng Pan & Shengxiang Ge & Lang Bai & Chaomin Ke & Yanlin Liu & Lixin Lang & Shoujun Zhu & Haitao Sun & Yanbao Yu & Xiaoyuan Chen, 2022. "A genetic engineering strategy for editing near-infrared-II fluorophores," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05113-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.