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An ionizable lipid toolbox for RNA delivery

Author

Listed:
  • Xuexiang Han

    (University of Pennsylvania)

  • Hanwen Zhang

    (University of Pennsylvania)

  • Kamila Butowska

    (University of Pennsylvania
    University of Gdańsk and Medical University of Gdańsk)

  • Kelsey L. Swingle

    (University of Pennsylvania)

  • Mohamad-Gabriel Alameh

    (University of Pennsylvania)

  • Drew Weissman

    (University of Pennsylvania)

  • Michael J. Mitchell

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

Abstract

Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.

Suggested Citation

  • Xuexiang Han & Hanwen Zhang & Kamila Butowska & Kelsey L. Swingle & Mohamad-Gabriel Alameh & Drew Weissman & Michael J. Mitchell, 2021. "An ionizable lipid toolbox for RNA delivery," Nature Communications, Nature, vol. 12(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27493-0
    DOI: 10.1038/s41467-021-27493-0
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    References listed on IDEAS

    as
    1. Kathryn A. Whitehead & J. Robert Dorkin & Arturo J. Vegas & Philip H. Chang & Omid Veiseh & Jonathan Matthews & Owen S. Fenton & Yunlong Zhang & Karsten T. Olejnik & Volkan Yesilyurt & Delai Chen & Sc, 2014. "Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity," Nature Communications, Nature, vol. 5(1), pages 1-10, September.
    2. Lei Miao & Jiaqi Lin & Yuxuan Huang & Linxian Li & Derfogail Delcassian & Yifan Ge & Yunhua Shi & Daniel G. Anderson, 2020. "Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
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    Cited by:

    1. Xuexiang Han & Ningqiang Gong & Lulu Xue & Margaret M. Billingsley & Rakan El-Mayta & Sarah J. Shepherd & Mohamad-Gabriel Alameh & Drew Weissman & Michael J. Mitchell, 2023. "Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Xuexiang Han & Junchao Xu & Ying Xu & Mohamad-Gabriel Alameh & Lulu Xue & Ningqiang Gong & Rakan El-Mayta & Rohan Palanki & Claude C. Warzecha & Gan Zhao & Andrew E. Vaughan & James M. Wilson & Drew W, 2024. "In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Yue Xu & Shihao Ma & Haotian Cui & Jingan Chen & Shufen Xu & Fanglin Gong & Alex Golubovic & Muye Zhou & Kevin Chang Wang & Andrew Varley & Rick Xing Ze Lu & Bo Wang & Bowen Li, 2024. "AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Kexin Su & Lu Shi & Tao Sheng & Xinxin Yan & Lixin Lin & Chaoyang Meng & Shiqi Wu & Yuxuan Chen & Yao Zhang & Chaorong Wang & Zichuan Wang & Junjie Qiu & Jiahui Zhao & Tengfei Xu & Yuan Ping & Zhen Gu, 2024. "Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. Xufei Bian & Ling Yang & Dingxi Jiang & Adam J. Grippin & Yifan Ma & Shuang Wu & Linchong Wu & Xiaoyou Wang & Zhongjie Tang & Kaicheng Tang & Weidong Pan & Shiyan Dong & Betty Y. S. Kim & Wen Jiang & , 2024. "Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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