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Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets

Author

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  • Richard Booth

    (Universidade de Santiago de Compostela)

  • Ignacio Insua

    (Universidade de Santiago de Compostela)

  • Sahnawaz Ahmed

    (Universidade de Santiago de Compostela)

  • Alicia Rioboo

    (Universidade de Santiago de Compostela)

  • Javier Montenegro

    (Universidade de Santiago de Compostela)

Abstract

One-dimensional (1D) supramolecular polymers are commonly found in natural and synthetic systems to prompt functional responses that capitalise on hierarchical molecular ordering. Despite amphiphilic self-assembly being significantly studied in the context of aqueous encapsulation and autopoiesis, very little is currently known about the physico-chemical consequences and functional role of 1D supramolecular polymerisation confined in aqueous compartments. Here, we describe the different phenomena that resulted from the chemically triggered supramolecular fibrillation of synthetic peptide amphiphiles inside water microdroplets. The confined connection of suitable dormant precursors triggered a physically autocatalysed chemical reaction that resulted in functional environmental responses such as molecular uptake, fusion and chemical exchange. These results demonstrate the potential of minimalistic 1D supramolecular polymerisation to modulate the behaviour of individual aqueous entities with their environment and within communities.

Suggested Citation

  • Richard Booth & Ignacio Insua & Sahnawaz Ahmed & Alicia Rioboo & Javier Montenegro, 2021. "Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26681-2
    DOI: 10.1038/s41467-021-26681-2
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    References listed on IDEAS

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    1. Andrew J. Bissette & Barbara Odell & Stephen P. Fletcher, 2014. "Physical autocatalysis driven by a bond-forming thiol–ene reaction," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    2. Keisuke Aratsu & Rika Takeya & Brian R. Pauw & Martin J. Hollamby & Yuichi Kitamoto & Nobutaka Shimizu & Hideaki Takagi & Rie Haruki & Shin-ichi Adachi & Shiki Yagai, 2020. "Supramolecular copolymerization driven by integrative self-sorting of hydrogen-bonded rosettes," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    3. Ankit Jain & Shikha Dhiman & Ashish Dhayani & Praveen K. Vemula & Subi J. George, 2019. "Chemical fuel-driven living and transient supramolecular polymerization," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    4. Yang Song & Thomas C. T. Michaels & Qingming Ma & Zhou Liu & Hao Yuan & Shuichi Takayama & Tuomas P. J. Knowles & Ho Cheung Shum, 2018. "Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    5. Yang Song & Ulyana Shimanovich & Thomas C. T. Michaels & Qingming Ma & Jingmei Li & Tuomas P. J. Knowles & Ho Cheung Shum, 2016. "Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    6. Maarten Danial & Carmen My-Nhi Tran & Philip G. Young & Sébastien Perrier & Katrina A. Jolliffe, 2013. "Janus cyclic peptide–polymer nanotubes," Nature Communications, Nature, vol. 4(1), pages 1-13, December.
    7. Philipp Gruner & Birte Riechers & Benoît Semin & Jiseok Lim & Abigail Johnston & Kathleen Short & Jean-Christophe Baret, 2016. "Controlling molecular transport in minimal emulsions," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
    8. Ryou Kubota & Kazutoshi Nagao & Wataru Tanaka & Ryotaro Matsumura & Takuma Aoyama & Kenji Urayama & Itaru Hamachi, 2020. "Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
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    Cited by:

    1. Ayan Chatterjee & Surashree Goswami & Raushan Kumar & Janmejay Laha & Dibyendu Das, 2024. "Emergence of a short peptide based reductase via activation of the model hydride rich cofactor," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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