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Janus cyclic peptide–polymer nanotubes

Author

Listed:
  • Maarten Danial

    (Key Centre for Polymers & Colloids, School of Chemistry, The University of Sydney)

  • Carmen My-Nhi Tran

    (Key Centre for Polymers & Colloids, School of Chemistry, The University of Sydney)

  • Philip G. Young

    (School of Chemistry, The University of Sydney)

  • Sébastien Perrier

    (Key Centre for Polymers & Colloids, School of Chemistry, The University of Sydney
    The University of Warwick, Coventry)

  • Katrina A. Jolliffe

    (School of Chemistry, The University of Sydney)

Abstract

Self-assembled nanotubular structures have numerous potential applications but these are limited by a lack of control over size and functionality. Controlling these features at the molecular level may allow realization of the potential of such structures. Here we report a new generation of self-assembled cyclic peptide–polymer nanotubes with dual functionality in the form of either a Janus or mixed polymeric corona. A ‘relay’ synthetic strategy is used to prepare nanotubes with a demixing or mixing polymeric corona. Nanotube structure is assessed in solution using 1H–1H nuclear Overhauser effect spectroscopy NMR, and in bulk using differential scanning calorimetry. The Janus nanotubes form artificial pores in model phospholipid bilayers. These molecules provide a viable pathway for the development of intriguing nanotubular structures with dual functionality via a demixing or a mixing polymeric corona and may provide new avenues for the creation of synthetic transmembrane protein channel mimics.

Suggested Citation

  • Maarten Danial & Carmen My-Nhi Tran & Philip G. Young & Sébastien Perrier & Katrina A. Jolliffe, 2013. "Janus cyclic peptide–polymer nanotubes," Nature Communications, Nature, vol. 4(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3780
    DOI: 10.1038/ncomms3780
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    Cited by:

    1. Richard Booth & Ignacio Insua & Sahnawaz Ahmed & Alicia Rioboo & Javier Montenegro, 2021. "Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets," Nature Communications, Nature, vol. 12(1), pages 1-8, December.

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