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Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria

Author

Listed:
  • Yanping Long

    (Sichuan University)

  • Ling Li

    (Sichuan University
    Affiliated Hospital of North Sichuan Medical College)

  • Tao Xu

    (Sichuan University)

  • Xizheng Wu

    (Sichuan University)

  • Yun Gao

    (Sichuan University)

  • Jianbo Huang

    (Sichuan University)

  • Chao He

    (Sichuan University)

  • Tian Ma

    (Sichuan University)

  • Lang Ma

    (Sichuan University)

  • Chong Cheng

    (Sichuan University)

  • Changsheng Zhao

    (Sichuan University
    Sichuan University
    Sichuan University)

Abstract

Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug resistance. Here, we design a hedgehog artificial macrophage with atomic-catalytic centers to combat MRSA by mimicking the “capture and killing” process of macrophages. The experimental studies and theoretical calculations reveal that the synthesized materials can efficiently capture and kill MRSA by the hedgehog topography and substantial generation of •O2− and HClO with its Fe2N6O catalytic centers. The synthesized artificial macrophage exhibits a low minimal inhibition concentration (8 μg/mL Fe-Art M with H2O2 (100 μM)) to combat MRSA and rapidly promote the healing of bacteria-infected wounds on rabbit skin. We suggest that the application of this hedgehog artificial macrophage with “capture and killing” capability and high ROS-catalytic activity will open up a promising pathway to develop antibacterial materials for bionic and non-antibiotic disinfection strategies.

Suggested Citation

  • Yanping Long & Ling Li & Tao Xu & Xizheng Wu & Yun Gao & Jianbo Huang & Chao He & Tian Ma & Lang Ma & Chong Cheng & Changsheng Zhao, 2021. "Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26456-9
    DOI: 10.1038/s41467-021-26456-9
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    1. Xiaoyu Wang & Xuejiao J. Gao & Li Qin & Changda Wang & Li Song & Yong-Ning Zhou & Guoyin Zhu & Wen Cao & Shichao Lin & Liqi Zhou & Kang Wang & Huigang Zhang & Zhong Jin & Peng Wang & Xingfa Gao & Hui , 2019. "eg occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    2. Shubo Tian & Qiang Fu & Wenxing Chen & Quanchen Feng & Zheng Chen & Jian Zhang & Weng-Chon Cheong & Rong Yu & Lin Gu & Juncai Dong & Jun Luo & Chen Chen & Qing Peng & Claudia Draxl & Dingsheng Wang & , 2018. "Carbon nitride supported Fe2 cluster catalysts with superior performance for alkene epoxidation," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    3. Zhuobin Xu & Zhiyue Qiu & Qi Liu & Yixin Huang & Dandan Li & Xinggui Shen & Kelong Fan & Juqun Xi & Yunhao Gu & Yan Tang & Jing Jiang & Jialei Xu & Jinzhi He & Xingfa Gao & Yuan Liu & Hyun Koo & Xiyun, 2018. "Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
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    Cited by:

    1. Xiangqin Meng & Huizhen Fan & Lei Chen & Jiuyang He & Chaoyi Hong & Jiaying Xie & Yinyin Hou & Kaidi Wang & Xingfa Gao & Lizeng Gao & Xiyun Yan & Kelong Fan, 2024. "Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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