IDEAS home Printed from https://ideas.repec.org/a/gam/jsusta/v15y2023i3p1814-d1039321.html
   My bibliography  Save this article

Oxidative Stress Trajectories during Lifespan: The Possible Mediation Role of Hormones in Redox Imbalance and Aging

Author

Listed:
  • Roberto Bono

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Giulia Squillacioti

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Federica Ghelli

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Marco Panizzolo

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Rosanna Irene Comoretto

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Paola Dalmasso

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

  • Valeria Bellisario

    (Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy
    Post Graduate School of Medical Statistics, University of Torino, Via Santena 5 bis, 10126 Torino, Italy)

Abstract

Aging, a natural multifactorial process, increases Oxidative Stress (OS) and inflammatory responses. Sexual hormones could upregulate OS during lifespan, with opposite systemic effects: anti-oxidant protection and cellular pro-oxidant toxicity. Hormonal changes are crucial phases in human growth and aging, but their mediating role on OS is still incomplete. The main purpose of this work was to analyze the trend of OS during the lifespan and, in particular, during puberty and menopause. Data from standardized questionnaires and biological OS measurements (15-F2t-Isop) of 815 subjects (7–60 years old) from five previous studies (2009–2015) were analyzed. The age variable was categorized into two hormonal age windows: puberty and menopause. A regression model was performed to assess the association between 15-F2t-Isop and the hormonal age window, sex, weight, and smoking habits. The results showed a significant V-shape decrease of OS levels both during puberty [OR = −0.06 95% CI −0.07–−0.04, p = 0.41] and in menopause [OR = −1.01 95% CI −1.5–−0.5, p < 0.001], but only in females. Our results support the view that hormones, and specifically estrogen, could modulate OS, especially during puberty and menopause. The V-shape decreasing trend of OS may be related to intrinsic characteristics of estrogen, which is able to modulate and upregulate OS pro- and anti-oxidant mechanisms.

Suggested Citation

  • Roberto Bono & Giulia Squillacioti & Federica Ghelli & Marco Panizzolo & Rosanna Irene Comoretto & Paola Dalmasso & Valeria Bellisario, 2023. "Oxidative Stress Trajectories during Lifespan: The Possible Mediation Role of Hormones in Redox Imbalance and Aging," Sustainability, MDPI, vol. 15(3), pages 1-10, January.
    • Handle: RePEc:gam:jsusta:v:15:y:2023:i:3:p:1814-:d:1039321
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2071-1050/15/3/1814/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2071-1050/15/3/1814/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Valeria Bellisario & Pavilio Piccioni & Massimiliano Bugiani & Giulia Squillacioti & Stefano Levra & Carlo Gulotta & Giulio Mengozzi & Alberto Perboni & Elena Grignani & Roberto Bono, 2019. "Tobacco Smoke Exposure, Urban and Environmental Factors as Respiratory Disease Predictors in Italian Adolescents," IJERPH, MDPI, vol. 16(20), pages 1-11, October.
    2. Giulia Squillacioti & Valeria Bellisario & Elena Grignani & Giulio Mengozzi & Giulia Bardaglio & Paola Dalmasso & Roberto Bono, 2019. "The Asti Study: The Induction of Oxidative Stress in A Population of Children According to Their Body Composition and Passive Tobacco Smoking Exposure," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
    3. Roberto Bono & Valeria Bellisario & Roberta Tassinari & Giulia Squillacioti & Tilde Manetta & Massimiliano Bugiani & Enrica Migliore & Pavilio Piccioni, 2019. "Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents," IJERPH, MDPI, vol. 16(11), pages 1-10, June.
    4. Bedayah Amro & Maria Eugenia Ramirez Aristondo & Shaima Alsuwaidi & Basma Almaamari & Zeinab Hakim & Muna Tahlak & Arnaud Wattiez & Philippe R. Koninckx, 2022. "New Understanding of Diagnosis, Treatment and Prevention of Endometriosis," IJERPH, MDPI, vol. 19(11), pages 1-14, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Valeria Bellisario & Pavilio Piccioni & Massimiliano Bugiani & Giulia Squillacioti & Stefano Levra & Carlo Gulotta & Giulio Mengozzi & Alberto Perboni & Elena Grignani & Roberto Bono, 2019. "Tobacco Smoke Exposure, Urban and Environmental Factors as Respiratory Disease Predictors in Italian Adolescents," IJERPH, MDPI, vol. 16(20), pages 1-11, October.
    2. Giulia Squillacioti & Valeria Bellisario & Stefano Levra & Pavilio Piccioni & Roberto Bono, 2019. "Greenness Availability and Respiratory Health in a Population of Urbanised Children in North-Western Italy," IJERPH, MDPI, vol. 17(1), pages 1-11, December.
    3. Fan He & Tian Li & Junfen Lin & Fudong Li & Yujia Zhai & Tao Zhang & Xue Gu & Genming Zhao, 2020. "Passive Smoking Exposure in Living Environments Reduces Cognitive Function: A Prospective Cohort Study in Older Adults," IJERPH, MDPI, vol. 17(4), pages 1-11, February.
    4. Markus Braun & Doris Klingelhöfer & Gerhard M. Oremek & David Quarcoo & David A. Groneberg, 2020. "Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children—An Overview in Research Insights of the Last Few Years," IJERPH, MDPI, vol. 17(9), pages 1-25, May.
    5. Roberto Bono & Valeria Bellisario & Roberta Tassinari & Giulia Squillacioti & Tilde Manetta & Massimiliano Bugiani & Enrica Migliore & Pavilio Piccioni, 2019. "Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents," IJERPH, MDPI, vol. 16(11), pages 1-10, June.
    6. Enrico Cocchi & Valeria Bellisario & Francesco Cresi & Claudio Plazzotta & Claudio Cassardo & Consolata Siniscalco & Licia Peruzzi & Roberto Bono, 2023. "Air Pollution and Aeroallergens as Possible Triggers in Preterm Birth Delivery," IJERPH, MDPI, vol. 20(2), pages 1-15, January.
    7. Salome Sunday & Zubair Kabir, 2019. "Impact of Carers’ Smoking Status on Childhood Obesity in the Growing up in Ireland Cohort Study," IJERPH, MDPI, vol. 16(15), pages 1-12, August.
    8. Hyun-Seung Rhyu & Kyung-Shin Park, 2019. "Effects of Telephone Follow-Up Intervention on %Body Fat, Inflammatory Cytokines, and Oxidative Stress in Obese Hispanic Children," IJERPH, MDPI, vol. 16(16), pages 1-9, August.
    9. Valeria Bellisario & Rosanna Irene Comoretto & Paola Berchialla & Emanuele Koumantakis & Giulia Squillacioti & Alberto Borraccino & Roberto Bono & Patrizia Lemma & Lorena Charrier & Paola Dalmasso, 2022. "The Association between Greenness and Urbanization Level with Weight Status among Adolescents: New Evidence from the HBSC 2018 Italian Survey," IJERPH, MDPI, vol. 19(10), pages 1-10, May.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jsusta:v:15:y:2023:i:3:p:1814-:d:1039321. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.