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Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents

Author

Listed:
  • Roberto Bono

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Valeria Bellisario

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Roberta Tassinari

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Giulia Squillacioti

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Tilde Manetta

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Massimiliano Bugiani

    (Consultant of OMP (observatory of professional diseases) of the Turin Court Prosecutor’s Office, Turin 10100, Italy)

  • Enrica Migliore

    (Cancer Epidemiology, AOU Città della Salute e della Scienza di Torino, Turin 10126, Italy)

  • Pavilio Piccioni

    (Unit of Pneumology and Tisiology, National Health Service (ASL TO2), Torino 10100, Italy)

Abstract

Objectives. The purpose of this study was to investigate bisphenol A (BPA) and its role in the induction of oxidative stress and confirm the same for tobacco smoke. Methods. A total of 223 young, healthy students (7–19 years old) were recruited in Chivasso, Italy. A spot of urine of each subject was analyzed to quantify BPA, cotinine, and 15F2t-isoprostane. Results. BPA showed a slight increase of concentration proportional with increasing age, even though the 11–14 years age group had slightly lower results, inducing a V-shape. The same trend was observed for 15F2t-isoprostane and cotinine. The result of piecewise linear robust regression shows a break point of the effect of BPA on 15F2t-isoprostane at 6 ng/mg CREA ( p < 0.001). At higher levels, 15F2t-isoprostane shows an exponential increase by more than threefold for each one-log unit of BPA. An increase of oxidative stress due to BPA was observed, but only from 6 ng/mg of CREA up. Passive tobacco smoke is also able to induce an increase in oxidative stress. Conclusion. Prevention against BPA and passive tobacco smoke represents an important tool for promoting the highest health standard.

Suggested Citation

  • Roberto Bono & Valeria Bellisario & Roberta Tassinari & Giulia Squillacioti & Tilde Manetta & Massimiliano Bugiani & Enrica Migliore & Pavilio Piccioni, 2019. "Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents," IJERPH, MDPI, vol. 16(11), pages 1-10, June.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:11:p:2025-:d:237908
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    References listed on IDEAS

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    1. Giulia Squillacioti & Valeria Bellisario & Elena Grignani & Giulio Mengozzi & Giulia Bardaglio & Paola Dalmasso & Roberto Bono, 2019. "The Asti Study: The Induction of Oxidative Stress in A Population of Children According to Their Body Composition and Passive Tobacco Smoking Exposure," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
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    Cited by:

    1. Fan He & Tian Li & Junfen Lin & Fudong Li & Yujia Zhai & Tao Zhang & Xue Gu & Genming Zhao, 2020. "Passive Smoking Exposure in Living Environments Reduces Cognitive Function: A Prospective Cohort Study in Older Adults," IJERPH, MDPI, vol. 17(4), pages 1-11, February.
    2. Valeria Bellisario & Pavilio Piccioni & Massimiliano Bugiani & Giulia Squillacioti & Stefano Levra & Carlo Gulotta & Giulio Mengozzi & Alberto Perboni & Elena Grignani & Roberto Bono, 2019. "Tobacco Smoke Exposure, Urban and Environmental Factors as Respiratory Disease Predictors in Italian Adolescents," IJERPH, MDPI, vol. 16(20), pages 1-11, October.
    3. Roberto Bono & Giulia Squillacioti & Federica Ghelli & Marco Panizzolo & Rosanna Irene Comoretto & Paola Dalmasso & Valeria Bellisario, 2023. "Oxidative Stress Trajectories during Lifespan: The Possible Mediation Role of Hormones in Redox Imbalance and Aging," Sustainability, MDPI, vol. 15(3), pages 1-10, January.

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