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A Computational Model for Cardiomyocytes Mechano-Electric Stimulation to Enhance Cardiac Tissue Regeneration

Author

Listed:
  • Pau Urdeitx

    (Mechanical Engineering Department, School of Engineering and Architecture (EINA), University of Zaragoza, 50018 Zaragoza, Spain
    Aragon Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain
    Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 50018 Zaragoza, Spain)

  • Mohamed H. Doweidar

    (Mechanical Engineering Department, School of Engineering and Architecture (EINA), University of Zaragoza, 50018 Zaragoza, Spain
    Aragon Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain
    Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 50018 Zaragoza, Spain)

Abstract

Electrical and mechanical stimulations play a key role in cell biological processes, being essential in processes such as cardiac cell maturation, proliferation, migration, alignment, attachment, and organization of the contractile machinery. However, the mechanisms that trigger these processes are still elusive. The coupling of mechanical and electrical stimuli makes it difficult to abstract conclusions. In this sense, computational models can establish parametric assays with a low economic and time cost to determine the optimal conditions of in-vitro experiments. Here, a computational model has been developed, using the finite element method, to study cardiac cell maturation, proliferation, migration, alignment, and organization in 3D matrices, under mechano-electric stimulation. Different types of electric fields (continuous, pulsating, and alternating) in an intensity range of 50–350 Vm − 1 , and extracellular matrix with stiffnesses in the range of 10–40 kPa, are studied. In these experiments, the group’s morphology and cell orientation are compared to define the best conditions for cell culture. The obtained results are qualitatively consistent with the bibliography. The electric field orientates the cells and stimulates the formation of elongated groups. Group lengthening is observed when applying higher electric fields in lower stiffness extracellular matrix. Groups with higher aspect ratios can be obtained by electrical stimulation, with better results for alternating electric fields.

Suggested Citation

  • Pau Urdeitx & Mohamed H. Doweidar, 2020. "A Computational Model for Cardiomyocytes Mechano-Electric Stimulation to Enhance Cardiac Tissue Regeneration," Mathematics, MDPI, vol. 8(11), pages 1-23, October.
    • Handle: RePEc:gam:jmathe:v:8:y:2020:i:11:p:1875-:d:436683
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    References listed on IDEAS

    as
    1. S.J. Mousavi & M.H. Doweidar & M. Doblaré, 2014. "Computational modelling and analysis of mechanical conditions on cell locomotion and cell–cell interaction," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(6), pages 678-693, April.
    2. Seyed Jamaleddin Mousavi & Mohamed Hamdy Doweidar, 2015. "Three-Dimensional Numerical Model of Cell Morphology during Migration in Multi-Signaling Substrates," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-33, March.
    3. Ruilin Zhang & Peidong Han & Hongbo Yang & Kunfu Ouyang & Derek Lee & Yi-Fan Lin & Karen Ocorr & Guson Kang & Ju Chen & Didier Y. R. Stainier & Deborah Yelon & Neil C. Chi, 2013. "In vivo cardiac reprogramming contributes to zebrafish heart regeneration," Nature, Nature, vol. 498(7455), pages 497-501, June.
    4. Leonard Bosgraaf & Peter J M Van Haastert, 2009. "Navigation of Chemotactic Cells by Parallel Signaling to Pseudopod Persistence and Orientation," PLOS ONE, Public Library of Science, vol. 4(8), pages 1-11, August.
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    Cited by:

    1. Pau Urdeitx & Sandra Clara-Trujillo & Jose Luis Gomez Ribelles & Mohamed H. Doweidar, 2023. "Multiple Myeloma Cell Simulation Using an Agent-Based Framework Coupled with a Continuous Fluid Model," Mathematics, MDPI, vol. 11(8), pages 1-13, April.

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