Author
Listed:
- Pau Urdeitx
(Mechanical Engineering Department, School of Engineering and Architecture (EINA), University of Zaragoza, 50018 Zaragoza, Spain
Aragon Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 50018 Zaragoza, Spain)
- Sandra Clara-Trujillo
(Centre for Biomaterials and Tissue Engineering (CBIT), Universitat Politecnica de Valencia, 46022 Valencia, Spain
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 46022 Valencia, Spain)
- Jose Luis Gomez Ribelles
(Centre for Biomaterials and Tissue Engineering (CBIT), Universitat Politecnica de Valencia, 46022 Valencia, Spain
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 46022 Valencia, Spain)
- Mohamed H. Doweidar
(Mechanical Engineering Department, School of Engineering and Architecture (EINA), University of Zaragoza, 50018 Zaragoza, Spain
Aragon Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 50018 Zaragoza, Spain)
Abstract
Bone marrow mechanical conditions play a key role in multiple myeloma cancer. The complex mechanical and chemical conditions, as well as the interactions with other resident cells, hinder the development of effective treatments. Agent-based computational models, capable of defining the specific conditions for every single cell, can be a useful tool to identify the specific tumor microenvironment. In this sense, we have developed a novel hybrid 3D agent-based model with coupled fluid and particle dynamics to study multiple myeloma cells’ growth. The model, which considers cell–cell interactions, cell maturation, and cell proliferation, has been implemented by employing user-defined functions in the commercial software Fluent. To validate and calibrate the model, cell sedimentation velocity and cell proliferation rates have been compared with in vitro results, as well as with another previously in-house developed model. The results show that cell proliferation increased as cell–cell, and cell–extracellular matrix interactions increased, as a result of the reduction n maturation time. Cells in contact form cell aggregates, increasing cell–cell interactions and thus cell proliferation. Saturation in cell proliferation was observed when cell aggregates increased in size and the lack of space inhibited internal cells’ proliferation. Compared with the previous model, a huge reduction in computational costs was obtained, allowing for an increase in the number of simulated cells.
Suggested Citation
Pau Urdeitx & Sandra Clara-Trujillo & Jose Luis Gomez Ribelles & Mohamed H. Doweidar, 2023.
"Multiple Myeloma Cell Simulation Using an Agent-Based Framework Coupled with a Continuous Fluid Model,"
Mathematics, MDPI, vol. 11(8), pages 1-13, April.
Handle:
RePEc:gam:jmathe:v:11:y:2023:i:8:p:1824-:d:1121444
Download full text from publisher
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jmathe:v:11:y:2023:i:8:p:1824-:d:1121444. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.