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In vivo cardiac reprogramming contributes to zebrafish heart regeneration

Author

Listed:
  • Ruilin Zhang

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Peidong Han

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Hongbo Yang

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Kunfu Ouyang

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Derek Lee

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Yi-Fan Lin

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Karen Ocorr

    (Development and Aging Program, Sanford-Burnham Institute for Medical Research, La Jolla, California 92037, USA)

  • Guson Kang

    (University of California, San Francisco, San Francisco, California 94158, USA)

  • Ju Chen

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Didier Y. R. Stainier

    (University of California, San Francisco, San Francisco, California 94158, USA
    Present address: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.)

  • Deborah Yelon

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Neil C. Chi

    (University of California, San Diego, La Jolla, California 92093, USA
    Institute of Genomic Medicine, University of California, San Diego, La Jolla, California 92093, USA)

Abstract

A cardiac injury study in zebrafish reveals the plasticity of heart cell lineages as shown by a Notch-dependent transdifferentiation of atrial to ventricular cardiomyocytes, regenerating a cell type that is damaged in human heart failure.

Suggested Citation

  • Ruilin Zhang & Peidong Han & Hongbo Yang & Kunfu Ouyang & Derek Lee & Yi-Fan Lin & Karen Ocorr & Guson Kang & Ju Chen & Didier Y. R. Stainier & Deborah Yelon & Neil C. Chi, 2013. "In vivo cardiac reprogramming contributes to zebrafish heart regeneration," Nature, Nature, vol. 498(7455), pages 497-501, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12322
    DOI: 10.1038/nature12322
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    Citations

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    Cited by:

    1. Marga Albu & Eileen Affolter & Alessandra Gentile & Yanli Xu & Khrievono Kikhi & Sarah Howard & Carsten Kuenne & Rashmi Priya & Felix Gunawan & Didier Y. R. Stainier, 2024. "Distinct mechanisms regulate ventricular and atrial chamber wall formation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Pau Urdeitx & Mohamed H. Doweidar, 2020. "A Computational Model for Cardiomyocytes Mechano-Electric Stimulation to Enhance Cardiac Tissue Regeneration," Mathematics, MDPI, vol. 8(11), pages 1-23, October.

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