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Inflammatory Bowel Diseases in Spain: A View from the Present to the Future

Author

Listed:
  • Raquel Francés

    (Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 75005 Paris, France
    These authors contributed equally to this work.)

  • Yuanji Fu

    (INSERM, CNRS, Institut Necker Enfants Malades, Université Paris Cité, 75015 Paris, France
    These authors contributed equally to this work.)

  • Christophe Desterke

    (Faculté de Médecine du Kremlin Bicêtre, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France)

  • Jorge Mata-Garrido

    (INSERM U993, Unité Organisation Nucléaire et Oncogenèse, Institut Pasteur, Université Paris Cité, 75015 Paris, France)

Abstract

Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, presents a growing health challenge in Spain. This review examines the current understanding of IBD through the lens of genetics, epigenetics, and metabolism, offering insights into future directions for research and clinical management. Recent advancements in genetic studies have identified numerous susceptibility loci, highlighting the complex interplay between genetic predisposition and environmental triggers. Epigenetic modifications, including DNA methylation and histone modification, further elucidate the pathogenesis of IBD, underscoring the role of gene–environment interactions. Metabolic alterations, particularly in the gut microbiome, emerge as crucial factors influencing disease onset and progression. The integration of multi-omics approaches has enhanced our comprehension of the molecular mechanisms underlying IBD, paving the way for personalized medicine. Looking forward, this review emphasizes the need for longitudinal studies and advanced bioinformatics tools to decode the intricate networks involved in IBD. Additionally, we discuss the potential of novel therapeutic strategies, including epigenetic drugs and microbiome modulation, as promising avenues for improved patient outcomes. This comprehensive overview provides a foundation for future research aimed at unraveling the complexities of IBD and developing innovative treatments tailored to the Spanish population.

Suggested Citation

  • Raquel Francés & Yuanji Fu & Christophe Desterke & Jorge Mata-Garrido, 2024. "Inflammatory Bowel Diseases in Spain: A View from the Present to the Future," J, MDPI, vol. 7(4), pages 1-13, November.
    • Handle: RePEc:gam:jjopen:v:7:y:2024:i:4:p:30-501:d:1520483
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    References listed on IDEAS

    as
    1. Jorge Mata-Garrido & Yao Xiang & Yunhua Chang-Marchand & Caroline Reisacher & Elisabeth Ageron & Ida Chiara Guerrera & Iñigo Casafont & Aurelia Bruneau & Claire Cherbuy & Xavier Treton & Anne Dumay & , 2022. "The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. R. J. Xavier & D. K. Podolsky, 2007. "Unravelling the pathogenesis of inflammatory bowel disease," Nature, Nature, vol. 448(7152), pages 427-434, July.
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