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Unravelling the pathogenesis of inflammatory bowel disease

Author

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  • R. J. Xavier

    (Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, and,
    Center for Computational and Integrative Biology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • D. K. Podolsky

    (Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, and,)

Abstract

Multigene diseases Inflammatory bowel diseases (IBDs) — a broad classification that includes Crohn's disease and ulcerative colitis — are multigenic disorders that are also linked to various environmental components. Despite this complexity, considerable progress has been made in unravelling their pathogenesis. Ramnik Xavier and Daniel Podolsky review recent developments in the field. The genetics of IBDs point to roles for epithelial barrier function, innate and adaptive immunity in pathogenesis, while key environmental factors include commensal bacteria which may provoke dysregulated immune responses in the susceptible host. The advances made in understanding IBDs show what is possible in dissecting the pathogenesis of complex disorders: similar unbundling may be possible in heart disease, diabetes and other multigenic disorders. The cover shows an image of an activated human macrophage, one of several cell populations key to the pathogenesis of IBD.

Suggested Citation

  • R. J. Xavier & D. K. Podolsky, 2007. "Unravelling the pathogenesis of inflammatory bowel disease," Nature, Nature, vol. 448(7152), pages 427-434, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7152:d:10.1038_nature06005
    DOI: 10.1038/nature06005
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    Cited by:

    1. Ernesto Rosario-Hernández & Lissette Negrón Marín & Estrella Bacenet & Juan Velázquez De Jesús & Pablo López & Yasuhiro Yamamura & Ernesto Rosario-Hernández, 2019. "Biomarkers and Depression Associated to Type 2 Diabetes A Pilot Study," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 13(4), pages 10135-10141, January.
    2. Jixiang Zhang & Jianhong Wu & Xiulan Peng & Jia Song & Jun Wang & Weiguo Dong, 2014. "Associations between STAT3 rs744166 Polymorphisms and Susceptibility to Ulcerative Colitis and Crohn's Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-10, October.
    3. Rajita Menon & Vivek Ramanan & Kirill S Korolev, 2018. "Interactions between species introduce spurious associations in microbiome studies," PLOS Computational Biology, Public Library of Science, vol. 14(1), pages 1-20, January.
    4. Isabelle Cleynen & Peter Jüni & Geertruida E Bekkering & Eveline Nüesch & Camila T Mendes & Stefanie Schmied & Stefan Wyder & Eliane Kellen & Peter M Villiger & Paul Rutgeerts & Séverine Vermeire & Da, 2011. "Genetic Evidence Supporting the Association of Protease and Protease Inhibitor Genes with Inflammatory Bowel Disease: A Systematic Review," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-13, September.
    5. Eirini Mavropoulou & Nicolae-Catalin Mechie & Richard Knoop & Golo Petzold & Volker Ellenrieder & Steffen Kunsch & Yiannis Pilavakis & Ahmad Amanzada, 2020. "Association of serum interleukin-6 and soluble interleukin-2-receptor levels with disease activity status in patients with inflammatory bowel disease: A prospective observational study," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-15, May.

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