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Associations between STAT3 rs744166 Polymorphisms and Susceptibility to Ulcerative Colitis and Crohn's Disease: A Meta-Analysis

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  • Jixiang Zhang
  • Jianhong Wu
  • Xiulan Peng
  • Jia Song
  • Jun Wang
  • Weiguo Dong

Abstract

Background: Many studies have investigated the associations between the signal transducer and activator of transcription 3 (STAT3) in the susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). However, the results remain inconsistent. This meta-analysis determined the risk of STAT3 rs744166 polymorphism-conferred UC and CD susceptibility. Materials and Methods: Electronic databases, including PubMed, EMBASE and the Cochrane Library, were searched for all eligible studies that evaluated the association between STAT3 rs744166 polymorphisms with UC and CD risk up to August 21, 2014. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using fixed- or random-effects models. Results: Twelve studies containing 10298 patients with CD, 4244 patients with UC and 11191 controls were included in this meta-analysis. The results indicated that the STAT3 rs744166 polymorphism was associated with CD and UC susceptibility (CD: GA+AA vs. GG, OR = 1.20, 95%CI, 1.11–1.30, I2 = 0%, Punadjusted

Suggested Citation

  • Jixiang Zhang & Jianhong Wu & Xiulan Peng & Jia Song & Jun Wang & Weiguo Dong, 2014. "Associations between STAT3 rs744166 Polymorphisms and Susceptibility to Ulcerative Colitis and Crohn's Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0109625
    DOI: 10.1371/journal.pone.0109625
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    1. R. J. Xavier & D. K. Podolsky, 2007. "Unravelling the pathogenesis of inflammatory bowel disease," Nature, Nature, vol. 448(7152), pages 427-434, July.
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    1. Hang Su & Na Rei & Lei Zhang & Jiaxiang Cheng, 2018. "Meta-analyses of IL1A polymorphisms and the risk of several autoimmune diseases published in databases," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-18, June.

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