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Inflammation and Peripheral Arterial Disease

Author

Listed:
  • Salvatore Santo Signorelli

    (Department of Clinical and Experimental Medicine School of Medicine, University of Catania, 95122 Catania, Italy)

  • Elisa Marino

    (Department of Clinical and Experimental Medicine School of Medicine, University of Catania, 95122 Catania, Italy)

  • Salvatore Scuto

    (Department of Clinical and Experimental Medicine School of Medicine, University of Catania, 95122 Catania, Italy)

Abstract

Peripheral arterial disease (PAD) is an atherosclerotic disease closely associated with high morbidity and mortality in cardiac events. Inflammation is crucial in atherosclerosis both at triggering and in progression. Numerous inflammatory biomarkers (cytokines, matrix metalloproteinases (MMPs), selectin, intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) C-reactive protein (CRP), fibrinogen) have been measured in atherosclerotic diseases including PAD. This paper summarizes the data on the inflammatory biomarkers for PAD pathophysiology and highlights the most useful markers in monitoring PAD outcomes.

Suggested Citation

  • Salvatore Santo Signorelli & Elisa Marino & Salvatore Scuto, 2019. "Inflammation and Peripheral Arterial Disease," J, MDPI, vol. 2(2), pages 1-10, April.
    • Handle: RePEc:gam:jjopen:v:2:y:2019:i:2:p:12-151:d:219783
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    References listed on IDEAS

    as
    1. Peter Libby, 2002. "Inflammation in atherosclerosis," Nature, Nature, vol. 420(6917), pages 868-874, December.
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