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PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population

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  • Nonanzit Pérez-Hernández

    (Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico)

  • Gilberto Vargas-Alarcón

    (Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico)

  • Rosalinda Posadas-Sánchez

    (Department of Endocrinology, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico)

  • Nancy Martínez-Rodríguez

    (Community Health Research Department, Children’s Hospital of Mexico “Federico Gomez”, Ministry of Health (SSA), Mexico City 06720, Mexico)

  • Carlos Alfonso Tovilla-Zárate

    (Juarez Autonomous University of Tabasco, Multidisciplinary Academic Division of Comacalco, Villahermosa 86040, Mexico)

  • Adrián Asael Rodríguez-Cortés

    (Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico)

  • Oscar Pérez-Méndez

    (Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico)

  • Ruben Blachman-Braun

    (Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico)

  • José Manuel Rodríguez-Pérez

    (Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico)

Abstract

Single-nucleotide polymorphisms (SNPs) in the protein phosphatase and actin regulator 1 gene ( PHACTR1 ) have been associated with susceptibility to develop several diseases, including cardiovascular disease. The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. The genotype analysis was performed using 5’exonuclease TaqMan genotyping assays in a group of 994 patients with premature CAD and 703 controls. A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03–1.46, p -value ( p ) = 0.024). The two PHACTR1 polymorphisms were not in linkage disequilibrium. In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population.

Suggested Citation

  • Nonanzit Pérez-Hernández & Gilberto Vargas-Alarcón & Rosalinda Posadas-Sánchez & Nancy Martínez-Rodríguez & Carlos Alfonso Tovilla-Zárate & Adrián Asael Rodríguez-Cortés & Oscar Pérez-Méndez & Ruben B, 2016. "PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population," IJERPH, MDPI, vol. 13(8), pages 1-9, August.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:8:p:803-:d:75668
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    References listed on IDEAS

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    1. Jennifer L Bolton & Marlene C W Stewart & James F Wilson & Niall Anderson & Jackie F Price, 2013. "Improvement in Prediction of Coronary Heart Disease Risk over Conventional Risk Factors Using SNPs Identified in Genome-Wide Association Studies," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.
    2. Peter Libby, 2002. "Inflammation in atherosclerosis," Nature, Nature, vol. 420(6917), pages 868-874, December.
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