IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2020i1p119-d468753.html
   My bibliography  Save this article

Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

Author

Listed:
  • Mengying Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Siyue Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Xiaowen Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Junhui Wu

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Yao Wu

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Zijing Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Jiating Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Tao Wu

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Yonghua Hu

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

Abstract

Background: Carotid intima-media thickness (cIMT) has been associated with an elevated risk of ischemic stroke (IS) in several studies, but the results are inconsistent. We investigated whether the association between cIMT and IS varied across different IS subtypes, and further assessed gene–cIMT interactions’ association with IS risk. Methods: A total of 1048 IS cases (795 large-artery atherosclerosis (LAA) cases, 103 small-vessel occlusion (SVO) cases, and 150 other subtypes) and 2696 IS-free controls across 2179 families were included in the analysis. Self-reported IS cases were confirmed through medical records’ review and head imaging by computed tomography and/or magnetic resonance imaging. The mean values of the common cIMT obtained in bilateral distal and proximal carotid artery segments were used. The genotype information of rs2910164 polymorphism in microRNA-146a (miR-146a) was also collected. Results: We found that cIMT was significantly associated with a higher risk of IS and LAA subtype but not SVO subtype in the multivariate-adjusted models. The odds ratio (OR) and 95% confidence interval (CI) in the highest quartile versus the lowest quartile of cIMT was 2.48 (1.92–3.20) for IS and 2.75 (2.08–3.64) for LAA (both p trend <0.001). The results also showed that there was a significant interaction between cIMT and rs2910164 genotype with the risk of IS ( p interaction = 0.03) and LAA ( p interaction = 0.02). The associations of cIMT with IS and LAA were strengthened among participants carried rs2910164_GG genotype compared with those with rs2910164_CC genotype. Conclusions: Our results indicate that higher cIMT levels were significantly associated with IS and LAA subtype but not SVO subtype, and the relations were modified by rs2910164 polymorphism in miR-146a.

Suggested Citation

  • Mengying Wang & Siyue Wang & Xiaowen Wang & Junhui Wu & Yao Wu & Zijing Wang & Jiating Wang & Tao Wu & Yonghua Hu, 2020. "Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China," IJERPH, MDPI, vol. 18(1), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:119-:d:468753
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/1/119/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/1/119/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Peter Libby, 2002. "Inflammation in atherosclerosis," Nature, Nature, vol. 420(6917), pages 868-874, December.
    2. Peter Libby & Paul M Ridker & Göran K. Hansson, 2011. "Progress and challenges in translating the biology of atherosclerosis," Nature, Nature, vol. 473(7347), pages 317-325, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Marit Skogstad & Asgeir Mamen & Lars-Kristian Lunde & Bente Ulvestad & Dagfinn Matre & Hans Christian D. Aass & Reidun Øvstebø & Pia Nielsen & Kari N. Samuelsen & Øivind Skare & Per Anton Sirnes, 2019. "Shift Work Including Night Work and Long Working Hours in Industrial Plants Increases the Risk of Atherosclerosis," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
    2. Wen Kong & Xun Niu & Tianshu Zeng & Meixia Lu & Lulu Chen, 2015. "Impact of Treatment with Metformin on Adipocytokines in Patients with Polycystic Ovary Syndrome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-20, October.
    3. Nonanzit Pérez-Hernández & Gilberto Vargas-Alarcón & Rosalinda Posadas-Sánchez & Nancy Martínez-Rodríguez & Carlos Alfonso Tovilla-Zárate & Adrián Asael Rodríguez-Cortés & Oscar Pérez-Méndez & Ruben B, 2016. "PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population," IJERPH, MDPI, vol. 13(8), pages 1-9, August.
    4. Quefeng Li & Sijian Wang & Chiang-Ching Huang & Menggang Yu & Jun Shao, 2014. "Meta-analysis based variable selection for gene expression data," Biometrics, The International Biometric Society, vol. 70(4), pages 872-880, December.
    5. Mouna Achoui & David Appleton & Mahmood Ameen Abdulla & Khalijah Awang & Mustafa Ali Mohd & Mohd Rais Mustafa, 2010. "In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-κB Translocation and IKKβ Activity," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-13, December.
    6. Jonas Helgertz & Tommy Bengtsson, 2019. "The Long-Lasting Influenza: The Impact of Fetal Stress During the 1918 Influenza Pandemic on Socioeconomic Attainment and Health in Sweden, 1968–2012," Demography, Springer;Population Association of America (PAA), vol. 56(4), pages 1389-1425, August.
    7. Stephanie D. Ansley & Jeffrey T. Howard, 2021. "Dietary Intake and Elevated C-Reactive Protein Levels in US Military Veterans," IJERPH, MDPI, vol. 18(2), pages 1-15, January.
    8. Elżbieta Dembowska & Aleksandra Jaroń & Ewa Gabrysz-Trybek & Joanna Bladowska & Grzegorz Trybek, 2022. "Evaluation of Common Factors of Periodontitis and Cardiovascular Disease in Patients with the Acute Coronary Syndrome," IJERPH, MDPI, vol. 19(13), pages 1-14, July.
    9. Yun Hwan Kim & Min Ki Jeong & Hyuntae Park & Sang Kab Park, 2021. "Effects of Regular Taekwondo Intervention on Health-Related Physical Fitness, Cardiovascular Disease Risk Factors and Epicardial Adipose Tissue in Elderly Women with Hypertension," IJERPH, MDPI, vol. 18(6), pages 1-14, March.
    10. Todd, Megan A. & Shkolnikov, Vladimir M. & Goldman, Noreen, 2016. "Why are well-educated Muscovites more likely to survive? Understanding the biological pathways," Social Science & Medicine, Elsevier, vol. 157(C), pages 138-147.
    11. David J Lloyd & Joan Helmering & Stephen A Kaufman & James Turk & Matt Silva & Sergio Vasquez & David Weinstein & Brad Johnston & Clarence Hale & Murielle M Véniant, 2011. "A Volumetric Method for Quantifying Atherosclerosis in Mice by Using MicroCT: Comparison to En Face," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-9, April.
    12. Tae Kyeong Kim & Sejin Jeon & Seonjun Park & Seong-Keun Sonn & Seungwoon Seo & Joowon Suh & Jing Jin & Hyae Yon Kweon & Sinai Kim & Shin Hye Moon & Okhee Kweon & Bon-Hyeock Koo & Nayoung Kim & Hae-Ock, 2022. "2′–5′ oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    13. Joshua D. Landvatter & Bert N. Uchino & Timothy W. Smith & Jos A. Bosch, 2022. "Partner’s Perceived Social Support Influences Their Spouse’s Inflammation: An Actor–Partner Analysis," IJERPH, MDPI, vol. 19(2), pages 1-9, January.
    14. Peter Garvin & Lena Jonasson & Lennart Nilsson & Magnus Falk & Margareta Kristenson, 2015. "Plasma Matrix Metalloproteinase-9 Levels Predict First-Time Coronary Heart Disease: An 8-Year Follow-Up of a Community-Based Middle Aged Population," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-13, September.
    15. Salvatore Novo & Bonomo Vito & Di Piazza Mariaconcetta & Piero Levantino, 2017. "Metabolic Syndrome: From the Pathophysiology to the Treatment. A Comprehensive Review," International Journal of Sciences, Office ijSciences, vol. 6(08), pages 1-8, August.
    16. Bidossessi Wilfried Hounkpe & Rafaela de Oliveira Benatti & Benilton de Sá Carvalho & Erich Vinicius De Paula, 2020. "Identification of common and divergent gene expression signatures in patients with venous and arterial thrombosis using data from public repositories," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-19, August.
    17. Hidalgo, Arturo & Tello, Lourdes, 2023. "A numerical approach to a 2D porous-medium mathematical model: Application to an atherosclerosis problem," Applied Mathematics and Computation, Elsevier, vol. 441(C).
    18. Kanyarat Kanokphichayakrai & Watchara Kaewmahanin & Orathai Tangvarasittichai & Surapon Tangvarasittichai & Watchara Kaewmahanin, 2017. "Cardio-Ankle Vascular Index (CAVI) Measurement of Arterial Stiffness Associated with Cardiovascular Disease Risk Factors in Type 2 Diabetes Patients," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 5(1), pages 1-8, November.
    19. Moritz Kebschull & Manuela Haupt & Søren Jepsen & James Deschner & Georg Nickenig & Nikos Werner, 2013. "Mobilization of Endothelial Progenitors by Recurrent Bacteremias with a Periodontal Pathogen," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.
    20. Marit Skogstad & Lars-Kristian Lunde & Bente Ulvestad & Hans Christian D. Aass & Thomas Clemm & Asgeir Mamen & Øivind Skare, 2018. "The Effect of a Leisure Time Physical Activity Intervention Delivered via a Workplace: 15-Month Follow-Up Study," IJERPH, MDPI, vol. 15(2), pages 1-13, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:119-:d:468753. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.